MEU1 S-methyl-5-thioadenosine phosphorylase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MEU1
Official Full Name: S-methyl-5-thioadenosine phosphorylase
Primary source: SGD:S000004007
Locus tag: YLR017W
See related: AllianceGenome:SGD:S000004007; FungiDB:YLR017W; VEuPathDB:YLR017W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables S-methyl-5-thioadenosine phosphorylase activity and mRNA binding activity. Involved in L-methionine salvage from methylthioadenosine and glutamate biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in biliary tract benign neoplasm and diaphyseal medullary stenosis with malignant fibrous histiocytoma. Orthologous to human MTAP (methylthioadenosine phosphorylase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MEU1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (177608..178621)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mechanism of action of nicotinamide riboside is totally dependent on increased net NAD synthesis through two pathways, the Nrk1 pathway and the Urh1/Pnp1/Meu1 pathway, which is Nrk1 independent.
Title: Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables S-methyl-5-thioadenosine phosphorylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables S-methyl-5-thioadenosine phosphorylase activity	IDA Inferred from Direct Assay more info	PubMed
enables S-methyl-5-thioadenosine phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables S-methyl-5-thioadenosine phosphorylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in L-methionine salvage from methylthioadenosine	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-methionine salvage from methylthioadenosine	IDA Inferred from Direct Assay more info	PubMed
involved_in L-methionine salvage from methylthioadenosine	IEA Inferred from Electronic Annotation more info
involved_in L-methionine salvage from methylthioadenosine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glutamate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleoside metabolic process	IEA Inferred from Electronic Annotation more info
involved_in purine ribonucleoside salvage	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: S-methyl-5-thioadenosine phosphorylase

NP_013117.1

EC 2.4.2.28

Methylthioadenosine phosphorylase (MTAP); catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

177608..178621

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181904.1 → NP_013117.1 TPA: S-methyl-5-thioadenosine phosphorylase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013117.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VY19, E9P915, Q06899, Q07938

UniProtKB/TrEMBL

A7A0S2, B3LSZ0, B5VMV7, C7GXG3, C8ZCY9, G2WIL1, N1P020

Conserved Domains (1) summary

cd09010
Location:35 → 289

MTAP_SsMTAPII_like_MTIP; 5'-deoxy-5'-methylthioadenosine phosphorylases (MTAP) similar to Sulfolobus solfataricus MTAPII and Pseudomonas aeruginosa PAO1 5'-methylthioinosine phosphorylase (MTIP)