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    Aoc1 amine oxidase, copper-containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 76507, updated on 9-Dec-2024

    Summary

    Official Symbol
    Aoc1provided by MGI
    Official Full Name
    amine oxidase, copper-containing 1provided by MGI
    Primary source
    MGI:MGI:1923757
    See related
    Ensembl:ENSMUSG00000029811 AllianceGenome:MGI:1923757
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DAO; Abp1; 1600012D06Rik
    Summary
    Predicted to enable several functions, including heparin binding activity; metal ion binding activity; and oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. Predicted to be involved in putrescine metabolic process. Predicted to be located in bicellular tight junction and extracellular exosome. Predicted to be active in plasma membrane. Is expressed in mesonephros and urinary system. Orthologous to human AOC1 (amine oxidase copper containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 196.7), small intestine adult (RPKM 189.0) and 2 other tissues See more
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    Genomic context

    See Aoc1 in Genome Data Viewer
    Location:
    6 B2.3; 6 23.78 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48872189..48886122)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48895255..48909188)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 176A Neighboring gene predicted gene 44764 Neighboring gene predicted gene 7932 Neighboring gene STARR-seq mESC enhancer starr_15799 Neighboring gene amine oxidase copper containing 1-like 2 Neighboring gene predicted gene, 24348

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables copper ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables copper ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables diamine oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables diamine oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables diamine oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heparin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histamine oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histamine oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables organic cyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables primary methylamine oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables primary methylamine oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables putrescine oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables putrescine oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables quinone binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in putrescine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in putrescine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in putrescine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in bicellular tight junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    diamine oxidase [copper-containing]; amiloride-sensitive amine oxidase [copper-containing]
    Names
    ABP
    amiloride binding protein 1 (amine oxidase, copper-containing)
    amiloride-binding protein 1
    amiloride-sensitive amine oxidase
    amine oxidase copper domain-containing protein 1
    diamine oxidase
    histaminase
    NP_001155093.1
    NP_001155094.1
    NP_083914.2
    XP_030111522.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161621.1NP_001155093.1  diamine oxidase [copper-containing] precursor

      See identical proteins and their annotated locations for NP_001155093.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AC159547, AK146078
      Consensus CDS
      CCDS51767.1
      UniProtKB/TrEMBL
      E9PYN9, Q3UKB9
      Related
      ENSMUSP00000124085.2, ENSMUST00000162948.7
      Conserved Domains (3) summary
      pfam02727
      Location:44129
      Cu_amine_oxidN2; Copper amine oxidase, N2 domain
      pfam02728
      Location:146245
      Cu_amine_oxidN3; Copper amine oxidase, N3 domain
      pfam01179
      Location:305717
      Cu_amine_oxid; Copper amine oxidase, enzyme domain
    2. NM_001161622.1NP_001155094.1  diamine oxidase [copper-containing] precursor

      See identical proteins and their annotated locations for NP_001155094.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant (1). All three variants encode the same protein.
      Source sequence(s)
      AC159547, AK146078, BB868807
      Consensus CDS
      CCDS51767.1
      UniProtKB/TrEMBL
      E9PYN9, Q3UKB9
      Related
      ENSMUSP00000128816.2, ENSMUST00000167529.3
      Conserved Domains (3) summary
      pfam02727
      Location:44129
      Cu_amine_oxidN2; Copper amine oxidase, N2 domain
      pfam02728
      Location:146245
      Cu_amine_oxidN3; Copper amine oxidase, N3 domain
      pfam01179
      Location:305717
      Cu_amine_oxid; Copper amine oxidase, enzyme domain
    3. NM_029638.2NP_083914.2  diamine oxidase [copper-containing] precursor

      See identical proteins and their annotated locations for NP_083914.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant (1). All three variants encode the same protein.
      Source sequence(s)
      AC159547, AK146078, BY131896
      Consensus CDS
      CCDS51767.1
      UniProtKB/TrEMBL
      E9PYN9, Q3UKB9
      Related
      ENSMUSP00000031835.8, ENSMUST00000031835.14
      Conserved Domains (3) summary
      pfam02727
      Location:44129
      Cu_amine_oxidN2; Copper amine oxidase, N2 domain
      pfam02728
      Location:146245
      Cu_amine_oxidN3; Copper amine oxidase, N3 domain
      pfam01179
      Location:305717
      Cu_amine_oxid; Copper amine oxidase, enzyme domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      48872189..48886122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255662.1XP_030111522.1  amiloride-sensitive amine oxidase [copper-containing] isoform X1

      UniProtKB/TrEMBL
      E9PYN9, Q3UKB9
      Conserved Domains (3) summary
      pfam02727
      Location:44129
      Cu_amine_oxidN2; Copper amine oxidase, N2 domain
      pfam02728
      Location:146245
      Cu_amine_oxidN3; Copper amine oxidase, N3 domain
      pfam01179
      Location:305717
      Cu_amine_oxid; Copper amine oxidase, enzyme domain