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    Rasa2 RAS p21 protein activator 2 [ Mus musculus (house mouse) ]

    Gene ID: 114713, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rasa2provided by MGI
    Official Full Name
    RAS p21 protein activator 2provided by MGI
    Primary source
    MGI:MGI:2149960
    See related
    Ensembl:ENSMUSG00000032413 AllianceGenome:MGI:2149960
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GAP1m; 5430433H21Rik
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in intracellular signal transduction and negative regulation of Ras protein signal transduction. Predicted to be located in plasma membrane. Is expressed in brain and retina. Human ortholog(s) of this gene implicated in Noonan syndrome. Orthologous to human RASA2 (RAS p21 protein activator 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 4.5), limb E14.5 (RPKM 2.3) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rasa2 in Genome Data Viewer
    Location:
    9 E3.3; 9 50.66 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (96421353..96513665, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (96539300..96631612, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24959 Neighboring gene leucine rich repeat containing 78 Neighboring gene STARR-seq mESC enhancer starr_24962 Neighboring gene STARR-seq mESC enhancer starr_24963 Neighboring gene ubiquitin domain containing 2 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr9:96473690-96473991 Neighboring gene STARR-seq mESC enhancer starr_24966 Neighboring gene protein transport protein Sec61 subunit gamma-like Neighboring gene STARR-seq mESC enhancer starr_24967 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:96570433-96570620 Neighboring gene STARR-seq mESC enhancer starr_24971 Neighboring gene zinc finger and BTB domain containing 38 Neighboring gene RIKEN cDNA E030011O05 gene Neighboring gene STARR-positive B cell enhancer ABC_E9333 Neighboring gene STARR-seq mESC enhancer starr_24975 Neighboring gene STARR-positive B cell enhancer mm9_chr9:96654988-96655289 Neighboring gene STARR-positive B cell enhancer mm9_chr9:96659582-96659882 Neighboring gene RIKEN cDNA C430002N11 gene Neighboring gene STARR-positive B cell enhancer ABC_E11752

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structure-function relationships of the mouse Gap1m. Determination of the inositol 1,3,4,5-tetrakisphosphate-binding domain. Fukuda M, et al. J Biol Chem, 1996 Aug 2. PMID 8702543
    2. Quantitative trait loci for body size components in mice. Kenney-Hunt JP, et al. Mamm Genome, 2006 Jun. PMID 16783635
    3. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ras GTPase-activating protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053268.2 → NP_444498.2  ras GTPase-activating protein 2

      See identical proteins and their annotated locations for NP_444498.2

      Status: VALIDATED

      Source sequence(s)
      AC144935, AC161257
      Consensus CDS
      CCDS23416.1
      UniProtKB/Swiss-Prot
      G3X918, P58069
      UniProtKB/TrEMBL
      Q3U405
      Related
      ENSMUSP00000034984.7, ENSMUST00000034984.8
      Conserved Domains (7) summary
      smart00107
      Location:706 → 741
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:171 → 313
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:38 → 158
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      smart00323
      Location:300 → 640
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13370
      Location:589 → 721
      PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
      pfam00169
      Location:606 → 704
      PH; PH domain
      cl02569
      Location:322 → 592
      RasGAP; Ras GTPase Activating Domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      96421353..96513665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510776.5 → XP_006510839.1  ras GTPase-activating protein 2 isoform X2

      UniProtKB/TrEMBL
      Q3U405
      Conserved Domains (5) summary
      smart00107
      Location:649 → 684
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:114 → 256
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd13370
      Location:532 → 664
      PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
      cl02569
      Location:265 → 535
      RasGAP; Ras GTPase Activating Domain
      cl14603
      Location:1 → 101
      C2; C2 domain

    2. XM_036154565.1 → XP_036010458.1  ras GTPase-activating protein 2 isoform X6

      Conserved Domains (3) summary
      smart00107
      Location:299 → 334
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd13370
      Location:182 → 314
      PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
      cl02569
      Location:1 → 185
      RasGAP; Ras GTPase Activating Domain

    3. XM_006510775.4 → XP_006510838.1  ras GTPase-activating protein 2 isoform X1

      UniProtKB/TrEMBL
      Q3U405
      Conserved Domains (5) summary
      smart00107
      Location:743 → 778
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:208 → 350
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:82 → 195
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      cd13370
      Location:626 → 758
      PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
      cl02569
      Location:359 → 629
      RasGAP; Ras GTPase Activating Domain

    4. XM_036154564.1 → XP_036010457.1  ras GTPase-activating protein 2 isoform X3

      Conserved Domains (3) summary
      cd04010
      Location:208 → 350
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:82 → 195
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      cl02569
      Location:359 → 620
      RasGAP; Ras GTPase Activating Domain

    5. XM_017313108.2 → XP_017168597.1  ras GTPase-activating protein 2 isoform X5

      Conserved Domains (3) summary
      cd04010
      Location:171 → 313
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:38 → 158
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      cl02569
      Location:322 → 557
      RasGAP; Ras GTPase Activating Domain

    6. XM_006510777.5 → XP_006510840.1  ras GTPase-activating protein 2 isoform X4

      Conserved Domains (3) summary
      cd04010
      Location:208 → 350
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:82 → 195
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      cl02569
      Location:359 → 594
      RasGAP; Ras GTPase Activating Domain

    RNA

    1. XR_004935308.1 RNA Sequence

    2. XR_004935307.1 RNA Sequence

    3. XR_004935304.1 RNA Sequence

    4. XR_004935305.1 RNA Sequence

    5. XR_004935306.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P58069.2 GenPept UniProtKB/Swiss-Prot:P58069

    Gene LinkOut

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