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    Zfp449 zinc finger protein 449 [ Mus musculus (house mouse) ]

    Gene ID: 78619, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp449provided by MGI
    Official Full Name
    zinc finger protein 449provided by MGI
    Primary source
    MGI:MGI:1925869
    See related
    Ensembl:ENSMUSG00000073176 AllianceGenome:MGI:1925869
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9530049C15Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within spermatogonial cell division. Is expressed in several structures, including central nervous system; connective tissue; gut; skeletal system; and urinary system. Orthologous to human ZNF449 (zinc finger protein 449). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 2.2), bladder adult (RPKM 1.6) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp449 in Genome Data Viewer
    Location:
    X A5; X 30.06 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (55391757..55411034)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (56346397..56365674)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1600025M17 gene Neighboring gene predicted gene, 38625 Neighboring gene small integral membrane protein 10 like 2A Neighboring gene predicted gene 2155 Neighboring gene 40S ribosomal protein S23 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of SCAN domain zinc-finger gene ZNF449 as a novel factor of chondrogenesis. Okada K, et al. PLoS One, 2014. PMID 25546433, Free PMC Article
    2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatogonial cell division IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 449

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359276.1 → NP_001346205.1  zinc finger protein 449 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL683799, BC082594, CR954970, CR955029
      Conserved Domains (3) summary
      COG5048
      Location:203 → 354
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:205 → 225
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:357 → 382
      zf-H2C2_2; Zinc-finger double domain

    2. NM_030139.5 → NP_084415.1  zinc finger protein 449 isoform 1

      See identical proteins and their annotated locations for NP_084415.1

      Status: VALIDATED

      Source sequence(s)
      AK036596, AK142888, BB527216, BC082594
      Consensus CDS
      CCDS30143.1
      UniProtKB/TrEMBL
      Q8CB76
      Related
      ENSMUSP00000099096.4, ENSMUST00000101560.4
      Conserved Domains (6) summary
      smart00431
      Location:27 → 134
      SCAN; leucine rich region
      COG5048
      Location:323 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:325 → 345
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:323 → 345
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:27 → 113
      SCAN; SCAN domain
      pfam13465
      Location:421 → 446
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      55391757..55411034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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