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    Asb11 ankyrin repeat and SOCS box-containing 11 [ Mus musculus (house mouse) ]

    Gene ID: 68854, updated on 9-Dec-2024

    Summary

    Official Symbol
    Asb11provided by MGI
    Official Full Name
    ankyrin repeat and SOCS box-containing 11provided by MGI
    Primary source
    MGI:MGI:1916104
    See related
    Ensembl:ENSMUSG00000031382 AllianceGenome:MGI:1916104
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110067L12Rik; 1600009D24Rik
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including endoplasmic reticulum unfolded protein response; positive regulation of protein catabolic process; and protein K11-linked ubiquitination. Predicted to be located in endoplasmic reticulum. Predicted to be part of Cul5-RING ubiquitin ligase complex. Orthologous to human ASB11 (ankyrin repeat and SOCS box containing 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in heart adult (RPKM 25.8), genital fat pad adult (RPKM 17.3) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Asb11 in Genome Data Viewer
    Location:
    X F5; X 76.53 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (163219976..163242166)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (164436953..164459170)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_48238 Neighboring gene vascular endothelial growth factor D Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:160844233-160844342 Neighboring gene STARR-seq mESC enhancer starr_48240 Neighboring gene STARR-positive B cell enhancer ABC_E269 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class A Neighboring gene chromobox protein homolog 1-like Neighboring gene ankyrin repeat and SOCS box-containing 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables ubiquitin-like ligase-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum unfolded protein response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K11-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of Cul5-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ankyrin repeat and SOCS box protein 11
    Names
    ASB-11
    ankyrin repeat and SOCS box-containing protein 11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313737.1NP_001300666.1  ankyrin repeat and SOCS box protein 11 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK005404, BU757326
      Consensus CDS
      CCDS85827.1
      UniProtKB/Swiss-Prot
      A2AIH7, Q3UJ13, Q9CQ31, Q9D0V1
      Related
      ENSMUSP00000044637.5, ENSMUST00000036858.11
      Conserved Domains (5) summary
      cd00204
      Location:66183
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:102189
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:66118
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:6695
      ANK; ANK repeat [structural motif]
      cl02533
      Location:282323
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    2. NM_026853.2NP_081129.1  ankyrin repeat and SOCS box protein 11 isoform 2

      See identical proteins and their annotated locations for NP_081129.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' end compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK004396, AK005404, AK078851, BU757326
      Consensus CDS
      CCDS30523.1
      UniProtKB/Swiss-Prot
      Q9CQ31
      Conserved Domains (3) summary
      sd00045
      Location:3766
      ANK; ANK repeat [structural motif]
      cl02533
      Location:253294
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl39094
      Location:33240
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      163219976..163242166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528972.5XP_006529035.2  ankyrin repeat and SOCS box protein 11 isoform X2

      Conserved Domains (3) summary
      sd00045
      Location:6695
      ANK; ANK repeat [structural motif]
      cl02533
      Location:237278
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl39094
      Location:39224
      Ank_2; Ankyrin repeats (3 copies)
    2. XM_006528971.5XP_006529034.2  ankyrin repeat and SOCS box protein 11 isoform X1

      Conserved Domains (3) summary
      PHA02874
      Location:69243
      PHA02874; ankyrin repeat protein; Provisional
      sd00045
      Location:129157
      ANK; ANK repeat [structural motif]
      cl02533
      Location:246287
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    3. XM_036162086.1XP_036017979.1  ankyrin repeat and SOCS box protein 11 isoform X3

      Related
      ENSMUSP00000033755.6, ENSMUST00000033755.6
      Conserved Domains (3) summary
      sd00045
      Location:3766
      ANK; ANK repeat [structural motif]
      cl02533
      Location:253294
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl39094
      Location:33240
      Ank_2; Ankyrin repeats (3 copies)
    4. XM_030251494.2XP_030107354.1  ankyrin repeat and SOCS box protein 11 isoform X6

      Conserved Domains (3) summary
      sd00045
      Location:3766
      ANK; ANK repeat [structural motif]
      cl02533
      Location:208249
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl39094
      Location:33195
      Ank_2; Ankyrin repeats (3 copies)
    5. XM_036162087.1XP_036017980.1  ankyrin repeat and SOCS box protein 11 isoform X5

      Conserved Domains (3) summary
      PHA02874
      Location:40214
      PHA02874; ankyrin repeat protein; Provisional
      sd00045
      Location:100128
      ANK; ANK repeat [structural motif]
      cl02533
      Location:217258
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    6. XM_006528974.5XP_006529037.1  ankyrin repeat and SOCS box protein 11 isoform X4

      Conserved Domains (3) summary
      sd00045
      Location:3059
      ANK; ANK repeat [structural motif]
      cl02533
      Location:246287
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl39094
      Location:22233
      Ank_2; Ankyrin repeats (3 copies)