U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CMR2 Cmr2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854260, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CMR2
    Official Full Name
    Cmr2p
    Primary source
    SGD:S000005619
    Locus tag
    YOR093C
    See related
    AllianceGenome:SGD:S000005619; FungiDB:YOR093C; VEuPathDB:YOR093C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DIP2
    Summary
    Involved in diacylglycerol metabolic process; response to osmotic stress; and vacuole fusion. Located in cellular bud neck and cytosol. Is active in vacuole-mitochondrion membrane contact site. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human DIP2A (disco interacting protein 2 homolog A); DIP2B (disco interacting protein 2 homolog B); and DIP2C (disco interacting protein 2 homolog C). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CMR2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (497506..502452, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Tma46p Neighboring gene putative ATPase ECM3 Neighboring gene Arf family GTPase ARF3 Neighboring gene ribose-5-phosphate isomerase RKI1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. DIP2 is a unique regulator of diacylglycerol lipid homeostasis in eukaryotes. Mondal S, et al. Elife, 2022 Jun 29. PMID 35766356, Free PMC Article
    2. Bayesian Markov Random Field analysis for protein function prediction based on network data. Kourmpetis YA, et al. PLoS One, 2010 Feb 24. PMID 20195360, Free PMC Article
    3. Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs. Mok J, et al. Sci Signal, 2010 Feb 16. PMID 20159853, Free PMC Article
    4. Identification of mitogen-activated protein kinase signaling pathways that confer resistance to endoplasmic reticulum stress in Saccharomyces cerevisiae. Chen Y, et al. Mol Cancer Res, 2005 Dec. PMID 16380504
    5. Snx4-assisted vacuolar targeting of transcription factors defines a new autophagy pathway for controlling ATG expression. Hanley SE, et al. Autophagy, 2021 Nov. PMID 33678121, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in diacylglycerol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vacuole-mitochondrion membrane contact site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Cmr2p
    NP_014736.1
    • Protein involved in regulation of diacylglycerol lipids levels; deletion causes sensitivity to unfolded protein response-inducing agents

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      497506..502452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183512.1 → NP_014736.1  TPA: Cmr2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014736.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2F4, Q12275
      UniProtKB/TrEMBL
      G2WMX0, N1NVS2
      Conserved Domains (3) summary
      cd05905
      Location:1004 → 1626
      Dip2; Disco-interacting protein 2 (Dip2)
      pfam06464
      Location:5 → 121
      DMAP_binding; DMAP1-binding Domain
      cl17068
      Location:179 → 893
      AFD_class_I; Adenylate forming domain, Class I superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12275.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools