Ephb1 Eph receptor B1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ephb1provided by RGD
Official Full Name: Eph receptor B1provided by RGD
Primary source: RGD:2556
See related: EnsemblRapid:ENSRNOG00000007865 AllianceGenome:RGD:2556
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Erk; elk; Ephb2
Summary: Enables protein tyrosine kinase activity. Involved in hindbrain tangential cell migration and protein autophosphorylation. Acts upstream of or within dendritic spine development and immunological synapse formation. Predicted to be located in several cellular components, including early endosome membrane; filopodium tip; and membrane raft. Predicted to be active in dendrite; glutamatergic synapse; and plasma membrane. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human EPHB1 (EPH receptor B1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 54.2), Testes (RPKM 9.3) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (111386432..111823759, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (102507549..102944839, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (110376954..110813193, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Corticosterone injection into the infralimbic prefrontal cortex enhances fear memory extinction: Involvement of GABA receptors and the extracellular signal-regulated kinase.
Title: Corticosterone injection into the infralimbic prefrontal cortex enhances fear memory extinction: Involvement of GABA receptors and the extracellular signal-regulated kinase.
Calcium-sensing receptor promotes calcium oxalate crystal adhesion and renal injury in Wistar rats by promoting ROS production and subsequent regulation of PS ectropion, OPN, KIM-1, and ERK expression.
Title: Calcium-sensing receptor promotes calcium oxalate crystal adhesion and renal injury in Wistar rats by promoting ROS production and subsequent regulation of PS ectropion, OPN, KIM-1, and ERK expression.
Peripheral EphrinB1/EphB1 signalling attenuates muscle hyperalgesia in MPS patients and a rat model of taut band-associated persistent muscle pain.
Title: Peripheral EphrinB1/EphB1 signalling attenuates muscle hyperalgesia in MPS patients and a rat model of taut band-associated persistent muscle pain.
In contrast to Na/K-ATPase alpha1, alpha3 could not regulate Src. Upon exposure to ouabain, Src activation did not occur, yet ERK was activated through Src-independent pathways involving PI3K and PKC. Hence, alpha3 expression confers signaling and pumping properties that are clearly distinct from that of cells expressing Na/K-ATPase alpha1.
Title: Src-independent ERK signaling through the rat α3 isoform of Na/K-ATPase.
These results indicate that CaMKII and ERK interact to promote activation in hypertrophy; the inhibition of CaMKII-ERK interaction offers a novel therapeutic approach to limit cardiac hypertrophy.
Title: Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy.
MEK/ERK activity controls the levels of MKP-1 and, thereby, regulates JNK activity in polyamine-depleted cells.
Title: The mechanism by which MEK/ERK regulates JNK and p38 activity in polyamine depleted IEC-6 cells during apoptosis.
results suggest that the PGE(2)-EP4-ERK pathway increases the number of osteo-adipogenic bipotential progenitor cells, with a resultant increase in adipogenesis in RC cell cultures.
Title: The EP4-ERK-dependent pathway stimulates osteo-adipogenic progenitor proliferation resulting in increased adipogenesis in fetal rat calvaria cell cultures.
In the pathogenesis of hyperoxia-induced lung fibrosis in neonatal rats, ERK phosphorylation might mediate angiotensin II type 1 receptor activation.
Title: Activation of the renin-angiotensin system in hyperoxia-induced lung fibrosis in neonatal rats.
identified expression of EphrinB1 in prostatic mesenchyme and suggest that the EphrinB signalling system acts as a regulator of prostate growth. EphrinB-EphB signalling may function as an autocrine regulator of mesenchyme
Title: Identification of EphrinB1 expression in prostatic mesenchyme and a role for EphB-EphrinB signalling in prostate development.
analysis of gamma-secretase cleavage of five substrates, APP, Notch1, N-cadherin, ephrinB and p75 neurotrophin receptor (p75-NTR) in membranes isolated from embryonic, young or old adult rat brains
Title: gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048713 (e-PCR)
- UniSTS:145163

AW535067 (e-PCR)
- UniSTS:247174

D8Got161 (e-PCR)
- UniSTS:112526

D8Rat167 (e-PCR), detects polymorphism
- UniSTS:228240

AU025535 (e-PCR)
- UniSTS:115167

Ephb1 (e-PCR), detects polymorphism
- UniSTS:266991

RH138061 (e-PCR)
- UniSTS:220148

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables axon guidance receptor activity	ISO Inferred from Sequence Orthology more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane-ephrin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane-ephrin receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane-ephrin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within camera-type eye morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-substrate adhesion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within central nervous system projection neuron axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in central nervous system projection neuron axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cranial nerve development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendritic spine development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in detection of temperature stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in detection of temperature stimulus involved in sensory perception of pain	ISS Inferred from Sequence or Structural Similarity more info
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ephrin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of cell polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hindbrain tangential cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immunological synapse formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of satellite cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of satellite cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of skeletal muscle satellite cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of skeletal muscle satellite cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in neural precursor cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in neurogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within optic nerve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within retinal ganglion cell axon guidance	ISO Inferred from Sequence Orthology more info
involved_in retinal ganglion cell axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in skeletal muscle satellite cell activation	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle satellite cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in filopodium tip	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ephrin type-B receptor 1

Names: ELK-related protein tyrosine kinase; Eph receptor B2 (ELK-related protein tyrosine kinase); tyrosine-protein kinase receptor EPH-2

NP_001097998.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001104528.1 → NP_001097998.1 ephrin type-B receptor 1 precursor

See identical proteins and their annotated locations for NP_001097998.1

Status: PROVISIONAL

Source sequence(s)

CH473954

UniProtKB/Swiss-Prot

P09759

UniProtKB/TrEMBL

A0A8I5Y8D1, A6I2H2

Related

ENSRNOP00000010634.7, ENSRNOT00000010634.7

Conserved Domains (5) summary

cd05065
Location:614 → 882

PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors

cd09551
Location:908 → 975

SAM_EPH-B1; SAM domain of EPH-B1 subfamily of tyrosine kinase receptors

cd10476
Location:20 → 195

EphR_LBD_B1; Ligand Binding Domain of Ephrin type-B Receptor 1

pfam00041
Location:435 → 518

fn3; Fibronectin type III domain

pfam14575
Location:542 → 616

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain