Rab5c RAB5C, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab5cprovided by MGI
Official Full Name: RAB5C, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:105306
See related: Ensembl:ENSMUSG00000019173 AllianceGenome:MGI:105306
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rabl
Summary: Predicted to enable GDP binding activity and GTPase activity. Acts upstream of or within endosome organization and regulation of endocytosis. Located in endocytic vesicle. Is expressed in several structures, including heart; intestine; liver; lung; and spleen. Orthologous to human RAB5C (RAB5C, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 167.3), duodenum adult (RPKM 128.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 63.54 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (100605829..100629041, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (100715003..100738215, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab5c promotes RSV and ADV replication by autophagy in respiratory epithelial cells.
Title: Rab5c promotes RSV and ADV replication by autophagy in respiratory epithelial cells.
Treatment of macrophages with IL-6 specifically induce the expression of Rab5 through the activation of extracellular signal-regulated kinase, whereas IL-12 exclusively upregulate the expression of Rab7 through the activation of p38 MAPK.
Title: IL-6 and IL-12 specifically regulate the expression of Rab5 and Rab7 via distinct signaling pathways.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D19348 (e-PCR)
- UniSTS:124808

AI326010 (e-PCR)
- UniSTS:160165

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GDP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endosome organization	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasma membrane to endosome transport	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of endocytosis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related protein Rab-5C

NP_001291932.1

EC 3.6.5.2

NP_077776.2

EC 3.6.5.2

XP_036012345.1

EC 3.6.5.2

XP_036012346.1

EC 3.6.5.2

XP_036012347.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305003.1 → NP_001291932.1 ras-related protein Rab-5C isoform 2

See identical proteins and their annotated locations for NP_001291932.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the penultimate exon, compared to variant 1. It encodes isoform 2 which is longer than isoform 1.

Source sequence(s)

AK159832, AL591469, BE447216, BY081527

Consensus CDS

CCDS79048.1

UniProtKB/TrEMBL

Q3TCT9, Q8C266

Related

ENSMUSP00000019317.6, ENSMUST00000019317.12

Conserved Domains (2) summary

cd01860
Location:21 → 201

Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

pfam00071
Location:23 → 202

Ras; Ras family
NM_024456.5 → NP_077776.2 ras-related protein Rab-5C isoform 1

See identical proteins and their annotated locations for NP_077776.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).

Source sequence(s)

AK159832, AL591469, BE447216, BY081527

Consensus CDS

CCDS36333.1

UniProtKB/Swiss-Prot

P35278, Q8R1V8, Q8R2N8

UniProtKB/TrEMBL

Q3TCT9, Q3TJ39

Related

ENSMUSP00000102987.2, ENSMUST00000107364.8

Conserved Domains (1) summary

cd01860
Location:21 → 183

Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

100605829..100629041 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156453.1 → XP_036012346.1 ras-related protein Rab-5C isoform X2

UniProtKB/TrEMBL

Q3TCT9

Conserved Domains (1) summary

cd01860
Location:67 → 229

Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
XM_036156452.1 → XP_036012345.1 ras-related protein Rab-5C isoform X1

Conserved Domains (1) summary

cd01860
Location:67 → 247

Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
XM_036156454.1 → XP_036012347.1 ras-related protein Rab-5C isoform X3

UniProtKB/Swiss-Prot

P35278, Q8R1V8, Q8R2N8

UniProtKB/TrEMBL

Q3TCT9, Q3TJ39

Conserved Domains (1) summary

cd01860
Location:21 → 183

Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion