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    Pced1a PC-esterase domain containing 1A [ Mus musculus (house mouse) ]

    Gene ID: 319513, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pced1aprovided by MGI
    Official Full Name
    PC-esterase domain containing 1Aprovided by MGI
    Primary source
    MGI:MGI:2442177
    See related
    Ensembl:ENSMUSG00000037773 AllianceGenome:MGI:2442177
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam113a; A930025D01Rik
    Summary
    Orthologous to human PCED1A (PC-esterase domain containing 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 12.2), limb E14.5 (RPKM 11.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pced1a in Genome Data Viewer
    Location:
    2 F1; 2 63.22 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (130259603..130266692, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (130417683..130424641, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700020A23 gene Neighboring gene transmembrane 239 Neighboring gene STARR-positive B cell enhancer ABC_E11708 Neighboring gene VSP16 CORVET/HOPS core subunit Neighboring gene predicted gene, 52562 Neighboring gene protein tyrosine phosphatase receptor type A Neighboring gene VISTA enhancer mm1313 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:130358070-130358271 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:130366029-130366233 Neighboring gene RIKEN cDNA 4930473A02 gene Neighboring gene STARR-positive B cell enhancer ABC_E7863

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    PC-esterase domain-containing protein 1A
    Names
    family with sequence similarity 113, member A
    protein FAM113A

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114541.2 → NP_001108013.1  PC-esterase domain-containing protein 1A

      See identical proteins and their annotated locations for NP_001108013.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BX890605
      Consensus CDS
      CCDS50711.1
      UniProtKB/Swiss-Prot
      A2BI89, Q6P1Z5
      Related
      ENSMUSP00000105906.2, ENSMUST00000110277.2
      Conserved Domains (1) summary
      cd01842
      Location:34 → 266
      SGNH_hydrolase_like_5; SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site ...

    2. NM_178762.5 → NP_848877.2  PC-esterase domain-containing protein 1A

      See identical proteins and their annotated locations for NP_848877.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BX890605
      Consensus CDS
      CCDS50711.1
      UniProtKB/Swiss-Prot
      A2BI89, Q6P1Z5
      Related
      ENSMUSP00000087009.5, ENSMUST00000089581.11
      Conserved Domains (1) summary
      cd01842
      Location:34 → 266
      SGNH_hydrolase_like_5; SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      130259603..130266692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162287.1 → XP_036018180.1  PC-esterase domain-containing protein 1A isoform X2

      Conserved Domains (1) summary
      cl01053
      Location:34 → 266
      SGNH_hydrolase; or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the typical ...

    2. XM_036162290.1 → XP_036018183.1  PC-esterase domain-containing protein 1A isoform X5

      Conserved Domains (1) summary
      cl01053
      Location:34 → 266
      SGNH_hydrolase; or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the typical ...

    3. XM_036162288.1 → XP_036018181.1  PC-esterase domain-containing protein 1A isoform X3

      Conserved Domains (1) summary
      cl01053
      Location:34 → 266
      SGNH_hydrolase; or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the typical ...

    4. XM_036162289.1 → XP_036018182.1  PC-esterase domain-containing protein 1A isoform X4

      UniProtKB/TrEMBL
      Q8BFT7, Q8BUE8, Q8BXP0
      Conserved Domains (1) summary
      cl01053
      Location:1 → 113
      SGNH_hydrolase; or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the typical ...

    5. XM_017318973.2 → XP_017174462.1  PC-esterase domain-containing protein 1A isoform X1

      UniProtKB/Swiss-Prot
      A2BI89, Q6P1Z5
      Conserved Domains (1) summary
      cd01842
      Location:34 → 266
      SGNH_hydrolase_like_5; SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P1Z5.2 GenPept UniProtKB/Swiss-Prot:Q6P1Z5

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