Dapl1 death associated protein-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dapl1provided by MGI
Official Full Name: death associated protein-like 1provided by MGI
Primary source: MGI:MGI:1923997
See related: Ensembl:ENSMUSG00000026989 AllianceGenome:MGI:1923997
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EEDA; 2310032F03Rik
Summary: Predicted to enable ribosome binding activity; translation initiation factor binding activity; and translation repressor activity. Involved in negative regulation of CD8-positive, alpha-beta T cell activation. Acts upstream of or within cell population proliferation and gene expression. Is active in nucleus. Is expressed in 1-cell stage embryo; cap mesenchyme; eye; integumental system; and tongue epithelium. Orthologous to human DAPL1 (death associated protein like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in genital fat pad adult (RPKM 6.1), testis adult (RPKM 1.7) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C1.1; 2 33.81 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (59314997..59335364)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (59484653..59505020)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DAPL1 deficiency in mice impairs antioxidant defenses in the RPE and leads to retinal degeneration with AMD-like features.
Title: DAPL1 deficiency in mice impairs antioxidant defenses in the RPE and leads to retinal degeneration with AMD-like features.
DAPL1 prevents epithelial-mesenchymal transition in the retinal pigment epithelium and experimental proliferative vitreoretinopathy.
Title: DAPL1 prevents epithelial-mesenchymal transition in the retinal pigment epithelium and experimental proliferative vitreoretinopathy.
DAPL1 is a novel regulator of testosterone production in Leydig cells of mouse testis.
Title: DAPL1 is a novel regulator of testosterone production in Leydig cells of mouse testis.
Authors show that DAPL1 is a novel regulator of RPE cell proliferation that is important for the maintenance of the RPE as a monolayer. The findings suggest that DAPL1 dysregulation may be involved in abnormal RPE-related proliferative diseases and corresponding retinal dysfunctions in humans.
Title: DAPL1, a susceptibility locus for age-related macular degeneration, acts as a novel suppressor of cell proliferation in the retinal pigment epithelium.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:492039

NoName (e-PCR)
- UniSTS:224638

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	ISS Inferred from Sequence or Structural Similarity more info
enables translation initiation factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables translation repressor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amino acid starvation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of CD8-positive, alpha-beta T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosome hibernation	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosome hibernation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: death-associated protein-like 1

Names: early epithelial differentiation-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.