Uck2 uridine-cytidine kinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Uck2provided by MGI
Official Full Name: uridine-cytidine kinase 2provided by MGI
Primary source: MGI:MGI:1931744
See related: Ensembl:ENSMUSG00000026558 AllianceGenome:MGI:1931744
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: UK; UMK; Umpk; TSA903
Summary: Predicted to enable cytidine kinase activity; identical protein binding activity; and uridine kinase activity. Predicted to be involved in CTP salvage and UMP salvage. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; cranium; integumental system; nervous system; and sensory organ. Orthologous to human UCK2 (uridine-cytidine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 18.8), CNS E11.5 (RPKM 15.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H2.3; 1 74.61 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (167050464..167112657, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (167222895..167285933, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Uridine-cytidine kinase 2 potentiates the mutagenic influence of the antiviral beta-d-N4-hydroxycytidine.
Title: Uridine-cytidine kinase 2 potentiates the mutagenic influence of the antiviral β-d-N4-hydroxycytidine.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234260

AU018180 (e-PCR)
- UniSTS:178500

RH136556 (e-PCR)
- UniSTS:210538

44.MMHAP10FG5.seq (e-PCR)
- UniSTS:124524

AI481316 (e-PCR)
- UniSTS:158877

RH125730 (e-PCR)
- UniSTS:162488

D1Mit400 (e-PCR), detects polymorphism
- UniSTS:128762

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cytidine kinase activity	ISO Inferred from Sequence Orthology more info
enables cytidine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables uridine kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables uridine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in CMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in CTP salvage	IEA Inferred from Electronic Annotation more info
involved_in CTP salvage	ISO Inferred from Sequence Orthology more info
involved_in CTP salvage	ISS Inferred from Sequence or Structural Similarity more info
involved_in UMP salvage	IEA Inferred from Electronic Annotation more info
involved_in UMP salvage	ISO Inferred from Sequence Orthology more info	PubMed
involved_in UMP salvage	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uridine-cytidine kinase 2

Names: UCK 2; cytidine monophosphokinase 2; uridine monophosphate kinase 2; uridine monophosphokinase 2

NP_001404848.1

EC 2.7.1.48

NP_001404849.1

EC 2.7.1.48

NP_001404850.1

EC 2.7.1.48

NP_001404851.1

EC 2.7.1.48

NP_001404852.1

EC 2.7.1.48

NP_001404853.1

EC 2.7.1.48

NP_109649.1

EC 2.7.1.48

XP_030099588.1

EC 2.7.1.48

XP_036010343.1

EC 2.7.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417919.1 → NP_001404848.1 uridine-cytidine kinase 2 isoform b

Status: VALIDATED

Source sequence(s)

AC142244

UniProtKB/TrEMBL

A0A0B4J1E5

Related

ENSMUSP00000027839.10, ENSMUST00000027839.14
NM_001417920.1 → NP_001404849.1 uridine-cytidine kinase 2 isoform c

Status: VALIDATED

Source sequence(s)

AC142244

UniProtKB/TrEMBL

Q8C476
NM_001417921.1 → NP_001404850.1 uridine-cytidine kinase 2 isoform d

Status: VALIDATED

Source sequence(s)

AC142244
NM_001417922.1 → NP_001404851.1 uridine-cytidine kinase 2 isoform e

Status: VALIDATED

Source sequence(s)

AC142244
NM_001417923.1 → NP_001404852.1 uridine-cytidine kinase 2 isoform e

Status: VALIDATED

Source sequence(s)

AC142244
NM_001417924.1 → NP_001404853.1 uridine-cytidine kinase 2 isoform e

Status: VALIDATED

Source sequence(s)

AC142244
NM_030724.4 → NP_109649.1 uridine-cytidine kinase 2 isoform a

See identical proteins and their annotated locations for NP_109649.1

Status: VALIDATED

Source sequence(s)

AC142244

Consensus CDS

CCDS15455.1

UniProtKB/Swiss-Prot

Q99PM9

UniProtKB/TrEMBL

Q543C2, Q8C476

Related

ENSMUSP00000060202.5, ENSMUST00000053686.9

Conserved Domains (1) summary

cd02023
Location:22 → 228

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

167050464..167112657 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243728.1 → XP_030099588.1 uridine-cytidine kinase 2 isoform X4

Conserved Domains (1) summary

cd02023
Location:35 → 176

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
XM_036154450.1 → XP_036010343.1 uridine-cytidine kinase 2 isoform X2

UniProtKB/TrEMBL

A0A0B4J1E5

Conserved Domains (1) summary

cd02023
Location:2 → 196

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...