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    Fryl FRY like transcription coactivator [ Mus musculus (house mouse) ]

    Gene ID: 72313, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Frylprovided by MGI
    Official Full Name
    FRY like transcription coactivatorprovided by MGI
    Primary source
    MGI:MGI:1919563
    See related
    Ensembl:ENSMUSG00000070733 AllianceGenome:MGI:1919563
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0826; 2010313D22Rik; 2310004H21Rik; 2510002A14Rik; 9030227G01Rik
    Summary
    Predicted to be involved in cell morphogenesis and neuron projection development. Predicted to be active in cell cortex and site of polarized growth. Is expressed in brain; exocrine system; retina nuclear layer; and tooth. Orthologous to human FRYL (FRY like transcription coactivator). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in thymus adult (RPKM 7.6), colon adult (RPKM 7.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fryl in Genome Data Viewer
    Location:
    5 C3.2; 5 38.44 cM
    Exon count:
    69
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (73177534..73414042, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (73020191..73256699, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 4 Neighboring gene zygote arrest 1, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3583 Neighboring gene RIKEN cDNA 1700071G01 gene Neighboring gene STARR-positive B cell enhancer ABC_E6338 Neighboring gene STARR-positive B cell enhancer ABC_E1302 Neighboring gene STARR-positive B cell enhancer ABC_E124 Neighboring gene RIKEN cDNA 1700025M24 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:73656832-73657076 Neighboring gene predicted gene, 57841 Neighboring gene STARR-seq mESC enhancer starr_13383 Neighboring gene predicted gene, 40316

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fryl deficiency is associated with defective kidney development and function in mice. Byun YS, et al. Exp Biol Med (Maywood), 2018 Mar. PMID 29409347, Free PMC Article
    2. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
    4. Placentation defects are highly prevalent in embryonic lethal mouse mutants. Perez-Garcia V, et al. Nature, 2018 Mar 22. PMID 29539633, Free PMC Article
    5. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fryl protein is required for normal development and functional maintenance of kidney in mice.
      Title: Fryl deficiency is associated with defective kidney development and function in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in site of polarized growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein furry homolog-like
    Names
    furry homolog-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028194.2 → NP_082470.2  protein furry homolog-like

      Status: VALIDATED

      Source sequence(s)
      AC108848, AK164590, AW489087, BC051118, BE650071, CD350880, CD550190, CD741721, CJ044706
      Consensus CDS
      CCDS19337.2
      UniProtKB/TrEMBL
      F8VQ05
      Related
      ENSMUSP00000098687.6, ENSMUST00000101127.12
      Conserved Domains (3) summary
      pfam14222
      Location:117 → 649
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2002 → 2255
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:687 → 1860
      MOR2-PAG1_mid; Cell morphogenesis central region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      73177534..73414042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504150.4 → XP_006504213.1  protein furry homolog-like isoform X17

      Conserved Domains (3) summary
      pfam14222
      Location:117 → 649
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2002 → 2255
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:687 → 1860
      MOR2-PAG1_mid; Cell morphogenesis central region

    2. XM_006504148.5 → XP_006504211.1  protein furry homolog-like isoform X16

      Conserved Domains (3) summary
      pfam14228
      Location:702 → 1875
      MOR2-PAG1_mid; Cell morphogenesis central region
      pfam14222
      Location:117 → 664
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2017 → 2270
      MOR2-PAG1_C; Cell morphogenesis C-terminal

    3. XM_030254825.2 → XP_030110685.1  protein furry homolog-like isoform X17

      Conserved Domains (3) summary
      pfam14222
      Location:117 → 649
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2002 → 2255
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:687 → 1860
      MOR2-PAG1_mid; Cell morphogenesis central region

    4. XM_006504149.5 → XP_006504212.1  protein furry homolog-like isoform X16

      Conserved Domains (3) summary
      pfam14228
      Location:702 → 1875
      MOR2-PAG1_mid; Cell morphogenesis central region
      pfam14222
      Location:117 → 664
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2017 → 2270
      MOR2-PAG1_C; Cell morphogenesis C-terminal

    5. XM_036165519.1 → XP_036021412.1  protein furry homolog-like isoform X16

      Conserved Domains (3) summary
      pfam14228
      Location:702 → 1875
      MOR2-PAG1_mid; Cell morphogenesis central region
      pfam14222
      Location:117 → 664
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2017 → 2270
      MOR2-PAG1_C; Cell morphogenesis C-terminal

    6. XM_006504152.5 → XP_006504215.1  protein furry homolog-like isoform X19

      Conserved Domains (3) summary
      pfam14222
      Location:213 → 745
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2096 → 2349
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:783 → 1954
      MOR2-PAG1_mid; Cell morphogenesis central region

    7. XM_006504145.5 → XP_006504208.1  protein furry homolog-like isoform X13

      Conserved Domains (3) summary
      pfam14222
      Location:213 → 745
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2098 → 2351
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:783 → 1956
      MOR2-PAG1_mid; Cell morphogenesis central region

    8. XM_006504144.5 → XP_006504207.1  protein furry homolog-like isoform X12

      Conserved Domains (3) summary
      pfam14222
      Location:213 → 745
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2098 → 2351
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:783 → 1956
      MOR2-PAG1_mid; Cell morphogenesis central region

    9. XM_036165518.1 → XP_036021411.1  protein furry homolog-like isoform X11

      Conserved Domains (3) summary
      pfam14228
      Location:798 → 1969
      MOR2-PAG1_mid; Cell morphogenesis central region
      pfam14222
      Location:213 → 760
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2111 → 2364
      MOR2-PAG1_C; Cell morphogenesis C-terminal

    10. XM_006504141.5 → XP_006504204.1  protein furry homolog-like isoform X6

      Conserved Domains (3) summary
      pfam14222
      Location:213 → 760
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2111 → 2364
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:798 → 1969
      MOR2-PAG1_mid; Cell morphogenesis central region

    11. XM_036165517.1 → XP_036021410.1  protein furry homolog-like isoform X10

      Conserved Domains (3) summary
      pfam14228
      Location:798 → 1970
      MOR2-PAG1_mid; Cell morphogenesis central region
      pfam14222
      Location:213 → 760
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2112 → 2365
      MOR2-PAG1_C; Cell morphogenesis C-terminal

    12. XM_006504139.5 → XP_006504202.1  protein furry homolog-like isoform X3

      Conserved Domains (3) summary
      pfam14222
      Location:213 → 760
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2112 → 2365
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:798 → 1970
      MOR2-PAG1_mid; Cell morphogenesis central region

    13. XM_030254824.2 → XP_030110684.1  protein furry homolog-like isoform X9

      Conserved Domains (3) summary
      pfam14222
      Location:213 → 760
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2112 → 2365
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:798 → 1970
      MOR2-PAG1_mid; Cell morphogenesis central region

    14. XM_036165516.1 → XP_036021409.1  protein furry homolog-like isoform X5

      Conserved Domains (3) summary
      pfam14228
      Location:798 → 1970
      MOR2-PAG1_mid; Cell morphogenesis central region
      pfam14222
      Location:213 → 760
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2112 → 2365
      MOR2-PAG1_C; Cell morphogenesis C-terminal

    15. XM_006504138.5 → XP_006504201.1  protein furry homolog-like isoform X2

      Conserved Domains (3) summary
      pfam14222
      Location:213 → 760
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2112 → 2365
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:798 → 1970
      MOR2-PAG1_mid; Cell morphogenesis central region

    16. XM_006504140.5 → XP_006504203.1  protein furry homolog-like isoform X4

      Conserved Domains (3) summary
      pfam14222
      Location:213 → 760
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2113 → 2366
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:798 → 1971
      MOR2-PAG1_mid; Cell morphogenesis central region

    17. XM_006504142.5 → XP_006504205.1  protein furry homolog-like isoform X7

      Conserved Domains (3) summary
      pfam14222
      Location:213 → 760
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2113 → 2366
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:798 → 1971
      MOR2-PAG1_mid; Cell morphogenesis central region

    18. XM_006504137.5 → XP_006504200.1  protein furry homolog-like isoform X1

      Conserved Domains (3) summary
      pfam14222
      Location:213 → 760
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2113 → 2366
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:798 → 1971
      MOR2-PAG1_mid; Cell morphogenesis central region

    19. XM_017321111.3 → XP_017176600.1  protein furry homolog-like isoform X14

      Conserved Domains (3) summary
      pfam14222
      Location:213 → 745
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2098 → 2351
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:783 → 1956
      MOR2-PAG1_mid; Cell morphogenesis central region

    20. XM_006504143.5 → XP_006504206.1  protein furry homolog-like isoform X8

      Conserved Domains (3) summary
      pfam14222
      Location:213 → 760
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2113 → 2366
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:798 → 1971
      MOR2-PAG1_mid; Cell morphogenesis central region

    21. XM_006504146.5 → XP_006504209.1  protein furry homolog-like isoform X15

      Conserved Domains (3) summary
      pfam14222
      Location:170 → 717
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2070 → 2323
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:755 → 1928
      MOR2-PAG1_mid; Cell morphogenesis central region

    22. XM_036165520.1 → XP_036021413.1  protein furry homolog-like isoform X18

      UniProtKB/TrEMBL
      Q8CHD0
      Conserved Domains (2) summary
      pfam14228
      Location:5 → 690
      MOR2-PAG1_mid; Cell morphogenesis central region
      pfam14225
      Location:832 → 1085
      MOR2-PAG1_C; Cell morphogenesis C-terminal

    RNA

    1. XR_001784749.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177136.3: Suppressed sequence

      Description
      NM_177136.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the 3' end appears to be intronic.
    Nucleotide Protein Strain
    Heading Accession and Version

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