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    Kbtbd3 kelch repeat and BTB (POZ) domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 69149, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kbtbd3provided by MGI
    Official Full Name
    kelch repeat and BTB (POZ) domain containing 3provided by MGI
    Primary source
    MGI:MGI:1916399
    See related
    Ensembl:ENSMUSG00000025893 AllianceGenome:MGI:1916399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bklhd3; 2200003A07Rik
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; genitourinary system; and tooth. Orthologous to human KBTBD3 (kelch repeat and BTB domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 1.3), bladder adult (RPKM 1.3) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kbtbd3 in Genome Data Viewer
    Location:
    9 2.46 cM; 9 A1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (4309743..4331829)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (4309743..4331829)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:4309539-4309751 Neighboring gene predicted gene, 53494 Neighboring gene aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Neighboring gene STARR-seq mESC enhancer starr_23158 Neighboring gene STARR-positive B cell enhancer ABC_E2280 Neighboring gene Myb/SANT-like DNA-binding domain containing 4 with coiled-coils Neighboring gene predicted gene, 53495 Neighboring gene glutamate receptor, ionotropic, AMPA4 (alpha 4) Neighboring gene STARR-seq mESC enhancer starr_23160 Neighboring gene predicted gene, 46101

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Global gene expression analysis of murine limb development. Taher L, et al. PLoS One, 2011. PMID 22174793, Free PMC Article
    2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kelch repeat and BTB domain-containing protein 3
    Names
    BTB and kelch domain containing 3
    BTB and kelch domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164574.2 → NP_001158046.1  kelch repeat and BTB domain-containing protein 3

      See identical proteins and their annotated locations for NP_001158046.1

      Status: VALIDATED

      Source sequence(s)
      AC115802
      Consensus CDS
      CCDS22795.1
      UniProtKB/Swiss-Prot
      Q8BHI4, Q8BNJ8
      Related
      ENSMUSP00000050183.8, ENSMUST00000049648.9
      Conserved Domains (3) summary
      PHA03098
      Location:38 → 582
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 385
      Kelch; KELCH repeat [structural motif]
      cd18271
      Location:24 → 153
      BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)

    2. NM_001433307.1 → NP_001420236.1  kelch repeat and BTB domain-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      AC115802
      UniProtKB/Swiss-Prot
      Q8BHI4, Q8BNJ8

    3. NM_001433308.1 → NP_001420237.1  kelch repeat and BTB domain-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      AC115802
      UniProtKB/Swiss-Prot
      Q8BHI4, Q8BNJ8

    4. NM_001433309.1 → NP_001420238.1  kelch repeat and BTB domain-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      AC115802
      UniProtKB/Swiss-Prot
      Q8BHI4, Q8BNJ8

    5. NM_001433310.1 → NP_001420239.1  kelch repeat and BTB domain-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      AC115802
      UniProtKB/Swiss-Prot
      Q8BHI4, Q8BNJ8

    6. NM_026962.4 → NP_081238.2  kelch repeat and BTB domain-containing protein 3

      See identical proteins and their annotated locations for NP_081238.2

      Status: VALIDATED

      Source sequence(s)
      AC115802
      Consensus CDS
      CCDS22795.1
      UniProtKB/Swiss-Prot
      Q8BHI4, Q8BNJ8
      Related
      ENSMUSP00000148445.2, ENSMUST00000212221.2
      Conserved Domains (3) summary
      PHA03098
      Location:38 → 582
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 385
      Kelch; KELCH repeat [structural motif]
      cd18271
      Location:24 → 153
      BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      4309743..4331829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242367.2 → XP_011240669.1  kelch repeat and BTB domain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011240669.1

      UniProtKB/Swiss-Prot
      Q8BHI4, Q8BNJ8
      Conserved Domains (3) summary
      PHA03098
      Location:38 → 582
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 385
      Kelch; KELCH repeat [structural motif]
      cd18271
      Location:24 → 153
      BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)

    2. XM_036155240.1 → XP_036011133.1  kelch repeat and BTB domain-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q8BHI4, Q8BNJ8
      Conserved Domains (3) summary
      PHA03098
      Location:38 → 582
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 385
      Kelch; KELCH repeat [structural motif]
      cd18271
      Location:24 → 153
      BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)

    3. XM_011242368.3 → XP_011240670.1  kelch repeat and BTB domain-containing protein 3 isoform X1

      Conserved Domains (3) summary
      PHA03098
      Location:38 → 582
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 385
      Kelch; KELCH repeat [structural motif]
      cd18271
      Location:24 → 153
      BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)

    4. XM_036155241.1 → XP_036011134.1  kelch repeat and BTB domain-containing protein 3 isoform X1

      Conserved Domains (3) summary
      PHA03098
      Location:38 → 582
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 385
      Kelch; KELCH repeat [structural motif]
      cd18271
      Location:24 → 153
      BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)

    5. XM_030244559.1 → XP_030100419.1  kelch repeat and BTB domain-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q8BHI4, Q8BNJ8
      Conserved Domains (3) summary
      PHA03098
      Location:38 → 582
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 385
      Kelch; KELCH repeat [structural motif]
      cd18271
      Location:24 → 153
      BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHI4.1 GenPept UniProtKB/Swiss-Prot:Q8BHI4

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