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    Pak3 p21 (RAC1) activated kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 18481, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pak3provided by MGI
    Official Full Name
    p21 (RAC1) activated kinase 3provided by MGI
    Primary source
    MGI:MGI:1339656
    See related
    Ensembl:ENSMUSG00000031284 AllianceGenome:MGI:1339656
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Stk4; PAK-3; Pak65beta; Pak65alpha
    Summary
    Enables protein kinase activity and small GTPase binding activity. Involved in axonogenesis; dendritic spine morphogenesis; and regulation of postsynapse organization. Acts upstream of or within cellular response to organic cyclic compound and dendritic spine development. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including central nervous system; gonad; liver; lung; and retina. Used to study non-syndromic X-linked intellectual disability 30. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 30. Orthologous to human PAK3 (p21 (RAC1) activated kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 8.0), whole brain E14.5 (RPKM 6.4) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pak3 in Genome Data Viewer
    Location:
    X F2; X 64.5 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (142301370..142580792)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (143518366..143797796)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene chordin-like 1 Neighboring gene predicted gene, 23325 Neighboring gene STARR-seq mESC enhancer starr_48031 Neighboring gene calpain 6 Neighboring gene doublecortin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MAP kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables MAP kinase kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dendritic spine development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of postsynapse organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density IEP
    Inferred from Expression Pattern
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase PAK 3
    Names
    CDC42/RAC effector kinase PAK-B
    beta-PAK
    p21 protein (Cdc42/Rac)-activated kinase 3
    p21-activated kinase 3
    NP_001181975.1
    NP_001181976.1
    NP_001181977.1
    NP_001181978.1
    NP_032804.2
    XP_006528815.1
    XP_006528816.1
    XP_006528817.1
    XP_011246092.1
    XP_030107108.1
    XP_030107109.1
    XP_030107110.1
    XP_030107111.1
    XP_036017734.1
    XP_036017735.1
    XP_036017736.1
    XP_036017737.1
    XP_036017738.1
    XP_036017739.1
    XP_036017740.1
    XP_036017741.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195046.1NP_001181975.1  serine/threonine-protein kinase PAK 3 isoform A

      See identical proteins and their annotated locations for NP_001181975.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (A).
      Source sequence(s)
      AL691499, BX530055, BX813331
      UniProtKB/TrEMBL
      B1GX81
      Conserved Domains (2) summary
      cd06656
      Location:284580
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      cd01093
      Location:68149
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    2. NM_001195047.1NP_001181976.1  serine/threonine-protein kinase PAK 3 isoform B

      See identical proteins and their annotated locations for NP_001181976.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform B), compared to isoform A.
      Source sequence(s)
      AL691499, BX530055, BX813331
      UniProtKB/TrEMBL
      B1GX80
      Conserved Domains (3) summary
      cd06656
      Location:269565
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      smart00220
      Location:289540
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam00786
      Location:69145
      PBD; P21-Rho-binding domain
    3. NM_001195048.1NP_001181977.1  serine/threonine-protein kinase PAK 3 isoform C

      See identical proteins and their annotated locations for NP_001181977.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform C), compared to isoform A.
      Source sequence(s)
      AK158893, AL691499, BX530055, BX813331
      Consensus CDS
      CCDS57779.1
      UniProtKB/Swiss-Prot
      O88645, Q61036, Q8K1R5, Q8K1R6
      Related
      ENSMUSP00000033640.8, ENSMUST00000033640.14
      Conserved Domains (2) summary
      cd06656
      Location:263559
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69141
      PBD; P21-Rho-binding domain
    4. NM_001195049.1NP_001181978.1  serine/threonine-protein kinase PAK 3 isoform D

      See identical proteins and their annotated locations for NP_001181978.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks two consecutive in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform D), compared to isoform A. Both variants 4 and 5 encode the same protein (isoform D).
      Source sequence(s)
      AL691499, BX530055, BX813331
      Consensus CDS
      CCDS30454.1
      UniProtKB/Swiss-Prot
      Q61036
      Related
      ENSMUSP00000108485.2, ENSMUST00000112864.8
      Conserved Domains (2) summary
      cd06656
      Location:248544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69126
      PBD; P21-Rho-binding domain
    5. NM_008778.3NP_032804.2  serine/threonine-protein kinase PAK 3 isoform D

      See identical proteins and their annotated locations for NP_032804.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks two consecutive in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform D), compared to isoform A. Both variants 4 and 5 encode the same protein (isoform D).
      Source sequence(s)
      AL691499, BX322533, BX530055, BX813331
      Consensus CDS
      CCDS30454.1
      UniProtKB/Swiss-Prot
      Q61036
      Related
      ENSMUSP00000126562.3, ENSMUST00000172330.3
      Conserved Domains (2) summary
      cd06656
      Location:248544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69126
      PBD; P21-Rho-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      142301370..142580792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161842.1XP_036017735.1  serine/threonine-protein kinase PAK 3 isoform X1

      UniProtKB/Swiss-Prot
      O88645, Q61036, Q8K1R5, Q8K1R6
      Conserved Domains (2) summary
      cd06656
      Location:263559
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69141
      PBD; P21-Rho-binding domain
    2. XM_036161844.1XP_036017737.1  serine/threonine-protein kinase PAK 3 isoform X1

      UniProtKB/Swiss-Prot
      O88645, Q61036, Q8K1R5, Q8K1R6
      Conserved Domains (2) summary
      cd06656
      Location:263559
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69141
      PBD; P21-Rho-binding domain
    3. XM_036161841.1XP_036017734.1  serine/threonine-protein kinase PAK 3 isoform X1

      UniProtKB/Swiss-Prot
      O88645, Q61036, Q8K1R5, Q8K1R6
      Conserved Domains (2) summary
      cd06656
      Location:263559
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69141
      PBD; P21-Rho-binding domain
    4. XM_036161846.1XP_036017739.1  serine/threonine-protein kinase PAK 3 isoform X2

      Conserved Domains (2) summary
      cd06656
      Location:248544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69126
      PBD; P21-Rho-binding domain
    5. XM_036161847.1XP_036017740.1  serine/threonine-protein kinase PAK 3 isoform X2

      Conserved Domains (2) summary
      cd06656
      Location:248544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69126
      PBD; P21-Rho-binding domain
    6. XM_011247790.4XP_011246092.1  serine/threonine-protein kinase PAK 3 isoform X2

      See identical proteins and their annotated locations for XP_011246092.1

      UniProtKB/Swiss-Prot
      Q61036
      Conserved Domains (2) summary
      cd06656
      Location:248544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69126
      PBD; P21-Rho-binding domain
    7. XM_030251249.2XP_030107109.1  serine/threonine-protein kinase PAK 3 isoform X2

      Conserved Domains (2) summary
      cd06656
      Location:248544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69126
      PBD; P21-Rho-binding domain
    8. XM_036161843.1XP_036017736.1  serine/threonine-protein kinase PAK 3 isoform X1

      UniProtKB/Swiss-Prot
      O88645, Q61036, Q8K1R5, Q8K1R6
      Related
      ENSMUSP00000108484.2, ENSMUST00000112863.8
      Conserved Domains (2) summary
      cd06656
      Location:263559
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69141
      PBD; P21-Rho-binding domain
    9. XM_030251248.2XP_030107108.1  serine/threonine-protein kinase PAK 3 isoform X1

      UniProtKB/Swiss-Prot
      O88645, Q61036, Q8K1R5, Q8K1R6
      Conserved Domains (2) summary
      cd06656
      Location:263559
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69141
      PBD; P21-Rho-binding domain
    10. XM_006528752.5XP_006528815.1  serine/threonine-protein kinase PAK 3 isoform X1

      See identical proteins and their annotated locations for XP_006528815.1

      UniProtKB/Swiss-Prot
      O88645, Q61036, Q8K1R5, Q8K1R6
      Conserved Domains (2) summary
      cd06656
      Location:263559
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69141
      PBD; P21-Rho-binding domain
    11. XM_030251251.2XP_030107111.1  serine/threonine-protein kinase PAK 3 isoform X2

      Conserved Domains (2) summary
      cd06656
      Location:248544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69126
      PBD; P21-Rho-binding domain
    12. XM_006528753.4XP_006528816.1  serine/threonine-protein kinase PAK 3 isoform X2

      See identical proteins and their annotated locations for XP_006528816.1

      UniProtKB/Swiss-Prot
      Q61036
      Related
      ENSMUSP00000108486.2, ENSMUST00000112865.8
      Conserved Domains (2) summary
      cd06656
      Location:248544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69126
      PBD; P21-Rho-binding domain
    13. XM_006528754.5XP_006528817.1  serine/threonine-protein kinase PAK 3 isoform X2

      See identical proteins and their annotated locations for XP_006528817.1

      UniProtKB/Swiss-Prot
      Q61036
      Conserved Domains (2) summary
      cd06656
      Location:248544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69126
      PBD; P21-Rho-binding domain
    14. XM_036161845.1XP_036017738.1  serine/threonine-protein kinase PAK 3 isoform X1

      UniProtKB/Swiss-Prot
      O88645, Q61036, Q8K1R5, Q8K1R6
      Conserved Domains (2) summary
      cd06656
      Location:263559
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69141
      PBD; P21-Rho-binding domain
    15. XM_030251250.2XP_030107110.1  serine/threonine-protein kinase PAK 3 isoform X2

      Conserved Domains (2) summary
      cd06656
      Location:248544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69126
      PBD; P21-Rho-binding domain
    16. XM_036161848.1XP_036017741.1  serine/threonine-protein kinase PAK 3 isoform X3

      Conserved Domains (1) summary
      cd06656
      Location:230526
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3