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    Cdc73 cell division cycle 73, Paf1/RNA polymerase II complex component [ Mus musculus (house mouse) ]

    Gene ID: 214498, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cdc73provided by MGI
    Official Full Name
    cell division cycle 73, Paf1/RNA polymerase II complex componentprovided by MGI
    Primary source
    MGI:MGI:2384876
    See related
    Ensembl:ENSMUSG00000026361 AllianceGenome:MGI:2384876
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hrpt2; 8430414L16Rik; C130030P16Rik
    Summary
    Predicted to enable RNA polymerase II complex binding activity. Involved in several processes, including cellular response to lipopolysaccharide; endodermal cell fate commitment; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of apoptotic process; regulation of cell growth; and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Cdc73/Paf1 complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Used to study hyperparathyroidism. Human ortholog(s) of this gene implicated in hyperparathyroidism and parathyroid carcinoma. Orthologous to human CDC73 (cell division cycle 73). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta adult (RPKM 8.5), CNS E11.5 (RPKM 3.0) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cdc73 in Genome Data Viewer
    Location:
    1 F; 1 62.52 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (143479014..143578631, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (143603276..143702893, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35244 Neighboring gene STARR-seq mESC enhancer starr_02523 Neighboring gene STARR-seq mESC enhancer starr_02525 Neighboring gene STARR-seq mESC enhancer starr_02526 Neighboring gene predicted gene, 35303 Neighboring gene UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 Neighboring gene STARR-positive B cell enhancer ABC_E7755 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_02529 Neighboring gene predicted gene, 38658 Neighboring gene predicted gene, 46161 Neighboring gene glutaredoxin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC29274, MGC36559

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endodermal cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA 3'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of G1/S transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of myeloid cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell cycle G1/S phase transition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mRNA 3'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein destabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transcription elongation by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of Cdc73/Paf1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Cdc73/Paf1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cdc73/Paf1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    parafibromin
    Names
    cell division cycle protein 73 homolog
    hyperparathyroidism 2 protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145991.2NP_666103.1  parafibromin

      See identical proteins and their annotated locations for NP_666103.1

      Status: VALIDATED

      Source sequence(s)
      AK048027, AK080861, AK134896, AK153645, AL592403, BB645172
      Consensus CDS
      CCDS15341.1
      UniProtKB/Swiss-Prot
      Q8JZM7
      Related
      ENSMUSP00000018337.8, ENSMUST00000018337.9
      Conserved Domains (2) summary
      pfam05179
      Location:357520
      CDC73_C; RNA pol II accessory factor, Cdc73 family, C-terminal
      pfam16050
      Location:1297
      CDC73_N; Paf1 complex subunit CDC73 N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      143479014..143578631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529366.4XP_006529429.1  parafibromin isoform X2

      Conserved Domains (1) summary
      pfam16050
      Location:1297
      CDC73_N; Paf1 complex subunit CDC73 N-terminal
    2. XM_006529365.2XP_006529428.1  parafibromin isoform X1

      Conserved Domains (1) summary
      pfam16050
      Location:1297
      CDC73_N; Paf1 complex subunit CDC73 N-terminal