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    Bclaf1 BCL2-associated transcription factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 72567, updated on 27-Nov-2024

    Summary

    Official Symbol
    Bclaf1provided by MGI
    Official Full Name
    BCL2-associated transcription factor 1provided by MGI
    Primary source
    MGI:MGI:1917580
    See related
    Ensembl:ENSMUSG00000037608 AllianceGenome:MGI:1917580
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Btf; mKIAA0164; 2610102K23Rik; 2700025J07Rik; 2810454G14Rik; 5730534O06Rik
    Summary
    Predicted to enable DNA binding activity and transcription coregulator activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in nuclear speck. Predicted to be part of mediator complex. Is expressed in several structures, including central nervous system; genitourinary system; retina; submandibular gland; and trachea. Orthologous to human BCLAF1 (BCL2 associated transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 24.7), CNS E14 (RPKM 17.4) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Bclaf1 in Genome Data Viewer
    Location:
    10 A3; 10 9.75 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (20187897..20218390)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (20310512..20342644)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30285 Neighboring gene STARR-seq mESC enhancer starr_25961 Neighboring gene microRNA 6413 Neighboring gene STARR-positive B cell enhancer ABC_E6822 Neighboring gene mitochondrial fission regulator 2 Neighboring gene 60S ribosomal protein L12 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0164, MGC30519, MGC58035

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    bcl-2-associated transcription factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025392.1 → NP_001020563.1  bcl-2-associated transcription factor 1 isoform 1

      See identical proteins and their annotated locations for NP_001020563.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC029682, BC034300, BY071148, CAAA01031508
      Consensus CDS
      CCDS35858.1
      UniProtKB/Swiss-Prot
      Q8BNZ0, Q8C2E9, Q8K019, Q9CSW5
      UniProtKB/TrEMBL
      Q3UDL9
      Related
      ENSMUSP00000043583.6, ENSMUST00000043881.12
      Conserved Domains (2) summary
      pfam15440
      Location:157 → 744
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
      cl09653
      Location:826 → 891
      Btz; CASC3/Barentsz eIF4AIII binding
    2. NM_001025393.1 → NP_001020564.1  bcl-2-associated transcription factor 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, as compared to variant 1. The encoded isoform 3 lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      BC086624, BY071148, CAAA01031508, CK637794, CN530237
      Consensus CDS
      CCDS23721.1
      UniProtKB/TrEMBL
      F8WI22, Q3UDL9
      Related
      ENSMUSP00000090349.4, ENSMUST00000092678.10
      Conserved Domains (1) summary
      pfam15440
      Location:157 → 744
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
    3. NM_153787.2 → NP_722482.1  bcl-2-associated transcription factor 1 isoform 2

      See identical proteins and their annotated locations for NP_722482.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a 6-nt segment in the CDS, as compared to variant 1. The encoded isoform 2 lacks 2 internal aa, as compared to isoform 1.
      Source sequence(s)
      BC034300, BY071148, CAAA01031508
      Consensus CDS
      CCDS78798.1
      UniProtKB/TrEMBL
      Q3UDL9
      Related
      ENSMUSP00000140623.2, ENSMUST00000185800.7
      Conserved Domains (2) summary
      pfam15440
      Location:155 → 742
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
      cl09653
      Location:824 → 889
      Btz; CASC3/Barentsz eIF4AIII binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      20187897..20218390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512865.5 → XP_006512928.1  bcl-2-associated transcription factor 1 isoform X1

      UniProtKB/TrEMBL
      Q3UDL9
      Conserved Domains (1) summary
      pfam15440
      Location:155 → 744
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
    2. XM_011243207.4 → XP_011241509.1  bcl-2-associated transcription factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A087WQA0, Q3TSZ0
      Related
      ENSMUSP00000140101.2, ENSMUST00000186100.7
      Conserved Domains (1) summary
      pfam15440
      Location:157 → 739
      THRAP3_BCLAF1; THRAP3/BCLAF1 family

    RNA

    1. XR_004936284.1 RNA Sequence

    2. XR_004936287.1 RNA Sequence

    3. XR_004936289.1 RNA Sequence

    4. XR_004936286.1 RNA Sequence

    5. XR_004936288.1 RNA Sequence

    6. XR_004936285.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001025394.1: Suppressed sequence

      Description
      NM_001025394.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.