U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ro60 Ro60, Y RNA binding protein [ Mus musculus (house mouse) ]

    Gene ID: 20822, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ro60provided by MGI
    Official Full Name
    Ro60, Y RNA binding proteinprovided by MGI
    Primary source
    MGI:MGI:106652
    See related
    Ensembl:ENSMUSG00000018199 AllianceGenome:MGI:106652
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ssa; Ssa2; Trove2; SS-A/Ro; 1810007I17Rik; A530054J02Rik
    Summary
    Enables U2 snRNA binding activity. Acts upstream of or within several processes, including cilium assembly; response to UV; and smoothened signaling pathway. Located in cytoplasm and nucleus. Part of ribonucleoprotein complex. Is expressed in embryo. Used to study systemic lupus erythematosus. Orthologous to human RO60 (Ro60, Y RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 5.5), CNS E18 (RPKM 5.4) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ro60 in Genome Data Viewer
    Location:
    1 F; 1 62.54 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (143626528..143652794, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (143750790..143777063, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02529 Neighboring gene predicted gene, 38658 Neighboring gene predicted gene, 46161 Neighboring gene glutaredoxin 2 Neighboring gene STARR-positive B cell enhancer ABC_E1564 Neighboring gene STARR-positive B cell enhancer ABC_E2564 Neighboring gene predicted gene, 25663 Neighboring gene STARR-positive B cell enhancer ABC_E499 Neighboring gene ubiquitin carboxyl-terminal esterase L5 Neighboring gene STARR-seq mESC enhancer starr_02532 Neighboring gene STARR-positive B cell enhancer ABC_E5813 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:145766106-145766315 Neighboring gene predicted gene, 41964 Neighboring gene STARR-seq mESC enhancer starr_02533

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables U2 snRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables misfolded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to interferon-alpha ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interferon-alpha ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within immune system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within response to UV IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to UV IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    RNA-binding protein Ro60
    Names
    60 kDa Ro protein
    60 kDa SS-A/Ro ribonucleoprotein
    60 kDa ribonucleoprotein Ro
    Sjogren syndrome antigen A2
    TROVE domain family, member 2
    roRNP

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013835.2NP_038863.1  RNA-binding protein Ro60

      See identical proteins and their annotated locations for NP_038863.1

      Status: VALIDATED

      Source sequence(s)
      AL592403, BQ032951, BY121097, U66843
      Consensus CDS
      CCDS15345.1
      UniProtKB/Swiss-Prot
      O08848, Q9QYD8
      UniProtKB/TrEMBL
      Q3TJ75, Q7TT40, Q80W12, Q8R562
      Related
      ENSMUSP00000125623.2, ENSMUST00000159879.2
      Conserved Domains (2) summary
      cd00198
      Location:372489
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam05731
      Location:16369
      TROVE; TROVE domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      143626528..143652794 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319451.3XP_017174940.1  RNA-binding protein Ro60 isoform X1

      UniProtKB/Swiss-Prot
      O08848, Q9QYD8
      UniProtKB/TrEMBL
      Q3TJ75, Q7TT40, Q80W12, Q8R562
      Conserved Domains (2) summary
      cd00198
      Location:372489
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam05731
      Location:16369
      TROVE; TROVE domain