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    Glrx2 glutaredoxin 2 [ Mus musculus (house mouse) ]

    Gene ID: 69367, updated on 9-Dec-2024

    Summary

    Official Symbol
    Glrx2provided by MGI
    Official Full Name
    glutaredoxin 2provided by MGI
    Primary source
    MGI:MGI:1916617
    See related
    Ensembl:ENSMUSG00000018196 AllianceGenome:MGI:1916617
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Grx2; 1700010P22Rik
    Summary
    Enables protein-disulfide reductase activity. Located in mitochondrion. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and respiratory system. Orthologous to human GLRX2 (glutaredoxin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 6.6), frontal lobe adult (RPKM 6.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Glrx2 in Genome Data Viewer
    Location:
    1 F; 1 62.53 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (143614787..143625416)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (143739224..143749678)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cell division cycle 73, Paf1/RNA polymerase II complex component Neighboring gene STARR-positive B cell enhancer ABC_E7755 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_02529 Neighboring gene predicted gene, 38658 Neighboring gene predicted gene, 46161 Neighboring gene Ro60, Y RNA binding protein Neighboring gene STARR-positive B cell enhancer ABC_E1564 Neighboring gene STARR-positive B cell enhancer ABC_E2564 Neighboring gene predicted gene, 25663 Neighboring gene ubiquitin carboxyl-terminal esterase L5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-disulfide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-disulfide reductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    glutaredoxin-2, mitochondrial
    Names
    thioltransferase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038592.1NP_001033681.1  glutaredoxin-2, mitochondrial isoform a

      See identical proteins and their annotated locations for NP_001033681.1

      Status: VALIDATED

      Source sequence(s)
      AK005853, AL592403, BY226480
      Consensus CDS
      CCDS15343.1
      UniProtKB/Swiss-Prot
      Q923X4, Q9DAG8, Q9JHY6
      UniProtKB/TrEMBL
      A2A5W4
      Related
      ENSMUSP00000141022.2, ENSMUST00000185362.7
      Conserved Domains (1) summary
      cd03419
      Location:61142
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
    2. NM_001038593.1NP_001033682.1  glutaredoxin-2, mitochondrial isoform b

      See identical proteins and their annotated locations for NP_001033682.1

      Status: VALIDATED

      Source sequence(s)
      AK005853, AL592403
      Consensus CDS
      CCDS15344.1
      UniProtKB/TrEMBL
      Q3UQ95
      Related
      ENSMUSP00000121665.2, ENSMUST00000145969.8
      Conserved Domains (1) summary
      cd03419
      Location:28109
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
    3. NM_001038594.1NP_001033683.1  glutaredoxin-2, mitochondrial isoform b

      See identical proteins and their annotated locations for NP_001033683.1

      Status: VALIDATED

      Source sequence(s)
      AK005853, AK142654, AL592403
      Consensus CDS
      CCDS15344.1
      UniProtKB/TrEMBL
      Q3UQ95
      Related
      ENSMUSP00000121010.2, ENSMUST00000129653.3
      Conserved Domains (1) summary
      cd03419
      Location:28109
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
    4. NM_023505.2NP_075994.2  glutaredoxin-2, mitochondrial isoform b

      See identical proteins and their annotated locations for NP_075994.2

      Status: VALIDATED

      Source sequence(s)
      AK005853, AL592403
      Consensus CDS
      CCDS15344.1
      UniProtKB/TrEMBL
      Q3UQ95
      Related
      ENSMUSP00000107588.4, ENSMUST00000111957.10
      Conserved Domains (1) summary
      cd03419
      Location:28109
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      143614787..143625416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529856.3XP_006529919.1  glutaredoxin-2, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006529919.1

      UniProtKB/TrEMBL
      Q3UQ95
      Conserved Domains (1) summary
      cd03419
      Location:28109
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
    2. XM_006529855.5XP_006529918.2  glutaredoxin-2, mitochondrial isoform X1

    3. XM_011248068.3XP_011246370.1  glutaredoxin-2, mitochondrial isoform X3

      Conserved Domains (1) summary
      cd03419
      Location:19100
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...