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    Arhgap5 Rho GTPase activating protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 11855, updated on 9-Dec-2024

    Summary

    Official Symbol
    Arhgap5provided by MGI
    Official Full Name
    Rho GTPase activating protein 5provided by MGI
    Primary source
    MGI:MGI:1332637
    See related
    Ensembl:ENSMUSG00000035133 AllianceGenome:MGI:1332637
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p190B; p190-B
    Summary
    Predicted to enable GTPase activator activity and SH2 domain binding activity. Acts upstream of or within several processes, including positive regulation of epithelial cell migration; positive regulation of mesenchymal cell proliferation; and regulation of cell size. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ARHGAP5 (Rho GTPase activating protein 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 9.8), frontal lobe adult (RPKM 6.6) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Arhgap5 in Genome Data Viewer
    Location:
    12 C1; 12 22.16 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (52550555..52618761)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (52503763..52571978)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35071 Neighboring gene predicted gene, 35135 Neighboring gene RIKEN cDNA 1700031P21 gene Neighboring gene STARR-seq mESC enhancer starr_32132 Neighboring gene STARR-positive B cell enhancer ABC_E4025 Neighboring gene predicted gene, 35239 Neighboring gene predicted gene, 24859

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables SH2 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 5
    Names
    rho-type GTPase-activating protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001408721.1NP_001395650.1  rho GTPase-activating protein 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114002, AC155819
      UniProtKB/Swiss-Prot
      E9PYT0, E9Q0L8, P97393
      Related
      ENSMUSP00000106353.2, ENSMUST00000110725.2
    2. NM_001408722.1NP_001395651.1  rho GTPase-activating protein 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114002, AC155819
      UniProtKB/Swiss-Prot
      E9PYT0, E9Q0L8, P97393
      Related
      ENSMUSP00000151809.2, ENSMUST00000219443.2
    3. NM_001408723.1NP_001395652.1  rho GTPase-activating protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114002, AC155819
    4. NM_001408724.1NP_001395653.1  rho GTPase-activating protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114002, AC155819
    5. NM_009706.3NP_033836.2  rho GTPase-activating protein 5 isoform 1

      See identical proteins and their annotated locations for NP_033836.2

      Status: VALIDATED

      Source sequence(s)
      AC114002, AC155819
      Consensus CDS
      CCDS36443.1
      UniProtKB/Swiss-Prot
      E9PYT0, E9Q0L8, P97393
      Conserved Domains (4) summary
      smart00441
      Location:428481
      FF; Contains two conserved F residues
      cd04373
      Location:12611445
      RhoGAP_p190; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an ...
      pfam16512
      Location:260338
      RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
      cl38936
      Location:31246
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. NR_176796.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC114002, AC155819
    2. NR_176797.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC114002, AC155819

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      52550555..52618761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)