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    Taf4 TATA-box binding protein associated factor 4 [ Mus musculus (house mouse) ]

    Gene ID: 228980, updated on 9-Dec-2024

    Summary

    Official Symbol
    Taf4provided by MGI
    Official Full Name
    TATA-box binding protein associated factor 4provided by MGI
    Primary source
    MGI:MGI:2152346
    See related
    Ensembl:ENSMUSG00000039117 AllianceGenome:MGI:2152346
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Taf4a; 135kDa; Taf2c1; TAFII130; TAFII135
    Summary
    Enables DNA binding activity. Acts upstream of or within DNA-templated transcription and ovarian follicle development. Located in male germ cell nucleus. Is expressed in brain; spinal cord; tail; and thymus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human TAF4 (TATA-box binding protein associated factor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 9.9), colon adult (RPKM 7.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Taf4 in Genome Data Viewer
    Location:
    2 H4; 2 102.42 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (179553945..179618519, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (179912146..179976646, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 36004 Neighboring gene cadherin 4 Neighboring gene STARR-seq mESC enhancer starr_06718 Neighboring gene STARR-seq mESC enhancer starr_06719 Neighboring gene STARR-seq mESC enhancer starr_06720 Neighboring gene STARR-seq mESC enhancer starr_06721 Neighboring gene STARR-seq mESC enhancer starr_06722 Neighboring gene predicted gene, 36066 Neighboring gene STARR-seq mESC enhancer starr_06724 Neighboring gene RIKEN cDNA 4921531C22 gene Neighboring gene STARR-seq mESC enhancer starr_06725 Neighboring gene STARR-positive B cell enhancer ABC_E7896 Neighboring gene LSM family member 14B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables aryl hydrocarbon receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of transcription factor TFTC complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transcription initiation factor TFIID subunit 4
    Names
    TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor
    TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1, 130kd

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081092.2NP_001074561.1  transcription initiation factor TFIID subunit 4

      Status: VALIDATED

      Source sequence(s)
      AL663067
      Consensus CDS
      CCDS38373.1
      UniProtKB/TrEMBL
      E9QAP7
      Related
      ENSMUSP00000038610.8, ENSMUST00000041618.13
      Conserved Domains (2) summary
      pfam05236
      Location:7911039
      TAF4; Transcription initiation factor TFIID component TAF4 family
      pfam07531
      Location:550633
      TAFH; NHR1 homology to TAF

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      179553945..179618519 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500588.2XP_006500651.2  transcription initiation factor TFIID subunit 4 isoform X1

      UniProtKB/TrEMBL
      A0A2I3BPN6
      Related
      ENSMUSP00000153863.2, ENSMUST00000227325.2
      Conserved Domains (2) summary
      pfam05236
      Location:7791027
      TAF4; Transcription initiation factor TFIID component TAF4 family
      pfam07531
      Location:550633
      TAFH; NHR1 homology to TAF

    RNA

    1. XR_004940192.1 RNA Sequence

    2. XR_004940194.1 RNA Sequence