U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Zfp748 zinc finger protein 748 [ Mus musculus (house mouse) ]

    Gene ID: 212276, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Zfp748provided by MGI
    Official Full Name
    zinc finger protein 748provided by MGI
    Primary source
    MGI:MGI:1916455
    See related
    Ensembl:ENSMUSG00000095432 AllianceGenome:MGI:1916455
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KRAB-O; Zfp208; mszf54; Rslcan20/21
    Summary
    Enables protein-macromolecule adaptor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in gonad; liver; and mesonephros. Orthologous to human ZNF721 (zinc finger protein 721) and ZNF845 (zinc finger protein 845). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 2.3), CNS E18 (RPKM 2.2) and 24 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Zfp748 in Genome Data Viewer
    Location:
    13 B3; 13 34.54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (67686758..67701257, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (67538641..67553152, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 458 pseudogene Neighboring gene zinc finger protein 87 Neighboring gene STARR-positive B cell enhancer ABC_E4076 Neighboring gene RIKEN cDNA 9430065F17 gene Neighboring gene STARR-positive B cell enhancer ABC_E9881 Neighboring gene zinc finger protein 729b Neighboring gene STARR-positive B cell enhancer ABC_E4077

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Functional analysis of the SRY-KRAB interaction in mouse sex determination. Polanco JC, et al. Biol Cell, 2009 Jan. PMID 18588511
    2. Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein. Oh HJ, et al. Biol Reprod, 2005 Feb. PMID 15469996
    3. Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery. Peng H, et al. J Biol Chem, 2009 Dec 18. PMID 19850934, Free PMC Article
    4. Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression. Krebs CJ, et al. Genes Dev, 2003 Nov 1. PMID 14563677, Free PMC Article
    5. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • KIAA4236, MGC60742, mKIAA423, 2610014M12Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    zinc finger protein 748
    Names
    KRAB zinc finger protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035231.4 → NP_001030308.1  zinc finger protein 748 isoform 1

      See identical proteins and their annotated locations for NP_001030308.1

      Status: VALIDATED

      Source sequence(s)
      CT573016
      Consensus CDS
      CCDS59589.1
      UniProtKB/TrEMBL
      Q7TPL6
      Related
      ENSMUSP00000137928.2, ENSMUST00000181892.9
      Conserved Domains (5) summary
      smart00349
      Location:5 → 63
      KRAB; krueppel associated box
      COG5048
      Location:442 → 875
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:782 → 802
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:5 → 44
      KRAB; KRAB box
      pfam13465
      Location:461 → 483
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001401856.1 → NP_001388785.1  zinc finger protein 748 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT573016
      UniProtKB/TrEMBL
      Q8BTB4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      67686758..67701257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_183145.2: Suppressed sequence

      Description
      NM_183145.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous