Trnp1 TMF1-regulated nuclear protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trnp1provided by MGI
Official Full Name: TMF1-regulated nuclear protein 1provided by MGI
Primary source: MGI:MGI:1916789
See related: Ensembl:ENSMUSG00000056596 AllianceGenome:MGI:1916789
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Trnp; 2300002D11Rik
Summary: Enables DNA binding activity. Involved in several processes, including cerebellar cortex morphogenesis; neural precursor cell proliferation; and regulation of cell population proliferation. Located in nucleus. Colocalizes with euchromatin. Is expressed in several structures, including bone; central nervous system; dorsal root ganglion; sensory organ; and submandibular gland primordium. Orthologous to human TRNP1 (TMF1 regulated nuclear protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cerebellum adult (RPKM 22.7), frontal lobe adult (RPKM 21.3) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.3; 4 66.25 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (133218408..133226446, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (133491097..133499645, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulatory and coding sequences of TRNP1 co-evolve with brain size and cortical folding in mammals.
Title: Regulatory and coding sequences of TRNP1 co-evolve with brain size and cortical folding in mammals.
Trnp1 organizes diverse nuclear membrane-less compartments in neural stem cells.
Title: Trnp1 organizes diverse nuclear membrane-less compartments in neural stem cells.
Data suggest that neurons in mouse brain exhibit DNA sequence encoding protein precursor, proMexneurin, that contains three peptide sequences: Mexneurin-1 (an endomorphin1-like peptide), Mexneurin-2 (an endomorphin1-like peptide), and Mexneurin-3 (peptide which appears to be unrelated to endomorphins); neurons exhibit expression of proMexneurin mRNA throughout mouse brain.
Title: Mexneurin is a novel precursor of peptides in the central nervous system of rodents.
Study identified Trnp1 as a regulator of mammalian brain development and as a key factor controlling neocortical expansion. Trnp1 levels have striking effects on tangential, radial, and lateral expansion of the cerebral cortex.
Title: Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cerebellar cortex morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with euchromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: TMF-regulated nuclear protein 1

Names: mexneurin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.