U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MRPL28 mitochondrial ribosomal protein L28 [ Homo sapiens (human) ]

    Gene ID: 10573, updated on 9-Dec-2024

    Summary

    Official Symbol
    MRPL28provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein L28provided by HGNC
    Primary source
    HGNC:HGNC:14484
    See related
    Ensembl:ENSG00000086504 MIM:604853; AllianceGenome:HGNC:14484
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p15; MAAT1; bL28m
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an HLA-A24-restricted fashion. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 24.9), kidney (RPKM 19.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MRPL28 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (366969..370538, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (361841..366186, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (416969..420538, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase family A member 2 Neighboring gene axin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:359414-359928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:359929-360443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:366745-367498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:367499-368250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:368251-369004 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:374949-375556 Neighboring gene Sharpr-MPRA regulatory region 4309 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:389458-390182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:391465-392016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10203 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6907 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6908 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6909 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6910 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6911 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:410874-411722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:411723-412570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:413199-413706 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:413707-414213 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:414214-414720 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:422268-422839 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:431071-431970 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6916 Neighboring gene uncharacterized LOC100134368 Neighboring gene post-GPI attachment to proteins 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:440484-440661 Neighboring gene ribosomal protein L23a pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:449109-449694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:450865-451450 Neighboring gene NME/NM23 nucleoside diphosphate kinase 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC8499

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    large ribosomal subunit protein bL28m
    Names
    39S ribosomal protein L28, mitochondrial
    L28mt
    MRP-L28
    melanoma antigen p15
    melanoma-associated antigen recognised by cytotoxic T lymphocytes
    melanoma-associated antigen recognized by T-lymphocytes
    mitochondrial large ribosomal subunit protein bL28m

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052909.1 RefSeqGene

      Range
      5032..8601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006428.5NP_006419.2  large ribosomal subunit protein bL28m

      See identical proteins and their annotated locations for NP_006419.2

      Status: REVIEWED

      Source sequence(s)
      AC005202, BC000507, BI862386, BM967049, DB469296, Z97634
      Consensus CDS
      CCDS32349.1
      UniProtKB/Swiss-Prot
      B2RCM4, D3DU46, Q13084, Q4TT39, Q96S26, Q9BQD8, Q9BR04
      UniProtKB/TrEMBL
      A2IDC6
      Related
      ENSP00000199706.7, ENST00000199706.13
      Conserved Domains (1) summary
      pfam00830
      Location:88136
      Ribosomal_L28; Ribosomal L28 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      366969..370538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522351.3XP_011520653.1  large ribosomal subunit protein bL28m isoform X1

      See identical proteins and their annotated locations for XP_011520653.1

      UniProtKB/Swiss-Prot
      B2RCM4, D3DU46, Q13084, Q4TT39, Q96S26, Q9BQD8, Q9BR04
      UniProtKB/TrEMBL
      A2IDC6
      Related
      ENSP00000374326.2, ENST00000389675.6
      Conserved Domains (1) summary
      pfam00830
      Location:88136
      Ribosomal_L28; Ribosomal L28 family
    2. XM_005255041.3XP_005255098.1  large ribosomal subunit protein bL28m isoform X1

      See identical proteins and their annotated locations for XP_005255098.1

      UniProtKB/Swiss-Prot
      B2RCM4, D3DU46, Q13084, Q4TT39, Q96S26, Q9BQD8, Q9BR04
      UniProtKB/TrEMBL
      A2IDC6
      Related
      ENSP00000390399.1, ENST00000447696.5
      Conserved Domains (1) summary
      pfam00830
      Location:88136
      Ribosomal_L28; Ribosomal L28 family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      361841..366186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379392.1XP_054235367.1  large ribosomal subunit protein bL28m isoform X1

      UniProtKB/Swiss-Prot
      B2RCM4, D3DU46, Q13084, Q4TT39, Q96S26, Q9BQD8, Q9BR04
      UniProtKB/TrEMBL
      A2IDC6