Akap11 A kinase anchor protein 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akap11provided by MGI
Official Full Name: A kinase anchor protein 11provided by MGI
Primary source: MGI:MGI:2684060
See related: Ensembl:ENSMUSG00000022016 AllianceGenome:MGI:2684060
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm80; PRKA11; AKAP220; mKIAA0629; 6330501D17Rik
Summary: Enables protein kinase A regulatory subunit binding activity. Acts upstream of or within cortical actin cytoskeleton organization; protein localization to endosome; and renal water homeostasis. Predicted to be located in several cellular components, including cytosol; nucleolus; and peroxisome. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; eye; genitourinary system; immune system; and nervous system. Orthologous to human AKAP11 (A-kinase anchoring protein 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in frontal lobe adult (RPKM 13.7), cortex adult (RPKM 12.2) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D3; 14 41.46 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (78729686..78774306, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (78492246..78536980, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients.
Title: Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients.
Data suggest that membrane-proximal signaling complexes constrained by AKAP220 impact the actin barrier dynamics and AQP2 trafficking to ensure water homeostasis.
Title: AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption.
IQGAP2 and AKAP220 act synergistically to sustain PKA-mediated recruitment of effectors such as Rac GTPases that impact the actin cytoskeleton
Title: Anchored protein kinase A recruitment of active Rac GTPase.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase A catalytic subunit binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A regulatory subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A regulatory subunit binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 1 binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to endosome	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein localization to endosome	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within renal water homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: A-kinase anchor protein 11

Names: A kinase (PRKA) anchor protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164503.1 → NP_001157975.1 A-kinase anchor protein 11 isoform 1

See identical proteins and their annotated locations for NP_001157975.1

Status: VALIDATED

Source sequence(s)

AC161608, AK032821, AK158300, AK164604

Consensus CDS

CCDS49549.1

UniProtKB/TrEMBL

E9Q777

Related

ENSMUSP00000116015.3, ENSMUST00000123853.9

Conserved Domains (1) summary

cl14906
Location:1808 → 1883

AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
NM_001346784.1 → NP_001333713.1 A-kinase anchor protein 11 isoform 2

Status: VALIDATED

Source sequence(s)

AC161608

Consensus CDS

CCDS84155.1

UniProtKB/TrEMBL

E9Q777

Conserved Domains (1) summary

cl14906
Location:1809 → 1884

AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

78729686..78774306 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158570.1 → XP_036014463.1 A-kinase anchor protein 11 isoform X3

Conserved Domains (1) summary

cl14906
Location:1638 → 1855

AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
XM_030247770.2 → XP_030103630.1 A-kinase anchor protein 11 isoform X1

Conserved Domains (1) summary

cl14906
Location:1809 → 1884

AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
XM_030247771.2 → XP_030103631.1 A-kinase anchor protein 11 isoform X2

Conserved Domains (1) summary

cl14906
Location:1801 → 1876

AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)