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    Rnf139 ring finger protein 139 [ Mus musculus (house mouse) ]

    Gene ID: 75841, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rnf139provided by MGI
    Official Full Name
    ring finger protein 139provided by MGI
    Primary source
    MGI:MGI:1923091
    See related
    Ensembl:ENSMUSG00000037075 AllianceGenome:MGI:1923091
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930555P18Rik
    Summary
    Predicted to enable protease binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including proteasomal protein catabolic process; protein destabilization; and regulation of protein metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be part of Derlin-1 retrotranslocation complex. Predicted to be active in endomembrane system. Is expressed in bladder; central nervous system; testis; and ureter. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human RNF139 (ring finger protein 139). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 73.5), liver E14 (RPKM 11.8) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf139 in Genome Data Viewer
    Location:
    15 D1; 15 25.09 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (58760975..58774239)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58889229..58902390)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3142 Neighboring gene tRNA methyltransferase 12 Neighboring gene predicted gene, 36509 Neighboring gene TatD DNase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_38762 Neighboring gene STARR-positive B cell enhancer ABC_E8590 Neighboring gene NADH:ubiquinone oxidoreductase subunit B9 Neighboring gene MTSS I-BAR domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E8591 Neighboring gene RIKEN cDNA 4930544F09 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TRC8 downregulation contributes to the development of non-alcoholic steatohepatitis by exacerbating hepatic endoplasmic reticulum stress. Chang PC, et al. Biochim Biophys Acta, 2015 Nov. PMID 26319415
    2. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of ER to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Derlin-1 retrotranslocation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Derlin-1 retrotranslocation complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF139
    Names
    RING-type E3 ubiquitin transferase RNF139
    translocation in renal carcinoma on chromosome 8 protein
    NP_780435.1
    XP_017172276.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175226.4 → NP_780435.1  E3 ubiquitin-protein ligase RNF139

      See identical proteins and their annotated locations for NP_780435.1

      Status: VALIDATED

      Source sequence(s)
      AK029069, AK033506, CJ180442
      Consensus CDS
      CCDS27494.1
      UniProtKB/Swiss-Prot
      Q7TMV1, Q8BZU9
      UniProtKB/TrEMBL
      A0A0R4J0K8
      Related
      ENSMUSP00000046467.7, ENSMUST00000036904.7
      Conserved Domains (2) summary
      cd16683
      Location:545 → 586
      RING-H2_RNF139; RING finger, H2 subclass, found in RING finger protein 139 (RNF139) and similar proteins
      pfam13705
      Location:19 → 516
      TRC8_N; TRC8 N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      58760975..58774239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316787.3 → XP_017172276.1  E3 ubiquitin-protein ligase RNF139 isoform X1

      UniProtKB/Swiss-Prot
      Q7TMV1, Q8BZU9
      Conserved Domains (2) summary
      cd16683
      Location:465 → 506
      RING-H2_RNF139; RING finger, H2 subclass, found in RING finger protein 139 (RNF139) and similar proteins
      pfam13705
      Location:5 → 436
      TRC8_N; TRC8 N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TMV1.1 GenPept UniProtKB/Swiss-Prot:Q7TMV1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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