Zglp1 zinc finger, GATA-like protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zglp1provided by MGI
Official Full Name: zinc finger, GATA-like protein 1provided by MGI
Primary source: MGI:MGI:3696042
See related: Ensembl:ENSMUSG00000079681 AllianceGenome:MGI:3696042
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Glp1
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in oocyte development; regulation of transcription by RNA polymerase II; and spermatogenesis. Located in nucleus. Is expressed in several structures, including gonad; heart; liver; lung; and spleen. Orthologous to human ZGLP1 (zinc finger GATA like protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 1.2), CNS E14 (RPKM 1.2) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A3; 9 7.7 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (20973689..20978389, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (21062393..21067093, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study shows that ZGLP1, a conserved transcriptional regulator with GATA-like zinc fingers, determines the oogenic fate in mice.
Title: ZGLP1 is a determinant for the oogenic fate in mice.
study provides a comprehensive multi-level (circuit, synaptic, and molecular) explanation of how food intake behavior and body weight are regulated by endogenous central GLP-1.
Title: Enhanced AMPA Receptor Trafficking Mediates the Anorexigenic Effect of Endogenous Glucagon-like Peptide-1 in the Paraventricular Hypothalamus.
data demonstrate an increase in number of pro-alpha cells and activation of the intra-islet GLP-1 system comprise a self-defense mechanism for enhancing beta cell survival to combat lipid overload, which is in part mediated by oxidative stress and inflammation.
Title: Endogenous GLP-1 as a key self-defense molecule against lipotoxicity in pancreatic islets.
Findings indicate an essential role for VAMP2 in GLP-1 exocytosis from the GLUTag L cell in response to a variety of established secretagogues.
Title: Role of vesicle-associated membrane protein 2 in exocytosis of glucagon-like peptide-1 from the murine intestinal L cell.
GLP-1 and analogues may provide neuroprotective actions in ALS
Title: Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis.
Loss of GLP-1 is associated with germ cell development during embryonic oogenesis.
Title: GATA-like protein-1 (GLP-1) is required for normal germ cell development during embryonic oogenesis.
data identify GLP-1 as a critical nuclear repressor in somatic cells of the gonad that is required for germ cell development, and highlight the importance of somatic-germ cell interactions in the regulation of this critical process
Title: GLP-1: a novel zinc finger protein required in somatic cells of the gonad for germ cell development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in oocyte development	IBA Inferred from Biological aspect of Ancestor more info
involved_in oocyte development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within oocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: GATA-type zinc finger protein 1

Names: GATA-like 1; GATA-like protein 1; GLP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001103168.1 → NP_001096638.1 GATA-type zinc finger protein 1

See identical proteins and their annotated locations for NP_001096638.1

Status: VALIDATED

Source sequence(s)

DQ286956

Consensus CDS

CCDS40549.1

UniProtKB/Swiss-Prot

Q1WG82

Related

ENSMUSP00000111157.3, ENSMUST00000115494.3

Conserved Domains (2) summary

smart00401
Location:194 → 231

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

pfam00320
Location:197 → 231

GATA; GATA zinc finger