Drd1 dopamine receptor D1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Drd1provided by MGI
Official Full Name: dopamine receptor D1provided by MGI
Primary source: MGI:MGI:99578
See related: Ensembl:ENSMUSG00000021478 AllianceGenome:MGI:99578
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Drd-1; Drd1a; Gpcr15; C030036C15Rik
Summary: Enables G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gs. Involved in adenylate cyclase-activating dopamine receptor signaling pathway; modification of postsynaptic structure; and presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including central nervous system development; learning or memory; and modulation of chemical synaptic transmission. Located in several cellular components, including dendritic spine; endoplasmic reticulum; and nucleus. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in hypertension and kidney failure. Orthologous to human DRD1 (dopamine receptor D1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cortex adult (RPKM 2.4), CNS E18 (RPKM 1.8) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B1; 13 28.4 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (54205202..54209677, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (54051183..54055658, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dopamine D1 receptor in medial prefrontal cortex mediates the effects of TAAR1 activation on chronic stress-induced cognitive and social deficits.
Title: Dopamine D1 receptor in medial prefrontal cortex mediates the effects of TAAR1 activation on chronic stress-induced cognitive and social deficits.
Leucine-rich repeat kinase 2 limits dopamine D1 receptor signaling in striatum and biases against heavy persistent alcohol drinking.
Title: Leucine-rich repeat kinase 2 limits dopamine D1 receptor signaling in striatum and biases against heavy persistent alcohol drinking.
Gm527 deficiency in dentate gyrus improves memory through upregulating dopamine D1 receptor pathway.
Title: Gm527 deficiency in dentate gyrus improves memory through upregulating dopamine D1 receptor pathway.
Excitatory Projections from the Prefrontal Cortex to Nucleus Accumbens Core D1-MSNs and kappa Opioid Receptor Modulate Itch-Related Scratching Behaviors.
Title: Excitatory Projections from the Prefrontal Cortex to Nucleus Accumbens Core D1-MSNs and κ Opioid Receptor Modulate Itch-Related Scratching Behaviors.
Nucleus Accumbens D1 Receptor-Expressing Spiny Projection Neurons Control Food Motivation and Obesity.
Title: Nucleus Accumbens D(1) Receptor-Expressing Spiny Projection Neurons Control Food Motivation and Obesity.
Activation of D1R signaling in the medial prefrontal cortex rescues maternal separation-induced behavioral deficits through restoration of excitatory neurotransmission.
Title: Activation of D1R signaling in the medial prefrontal cortex rescues maternal separation-induced behavioral deficits through restoration of excitatory neurotransmission.
Dopamine receptor D2, but not D1, mediates the reward circuit from the ventral tegmental area to the central amygdala, which is involved in pain relief.
Title: Dopamine receptor D2, but not D1, mediates the reward circuit from the ventral tegmental area to the central amygdala, which is involved in pain relief.
The Modification of Offspring Stress-Related Behavior and the Expression of Drd1, Drd2, and Nr3c1 by a Western-Pattern Diet in Mus Musculus.
Title: The Modification of Offspring Stress-Related Behavior and the Expression of Drd1, Drd2, and Nr3c1 by a Western-Pattern Diet in Mus Musculus.
The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus.
Title: The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus.
The DR1CSE/H2S system inhibits renal fibrosis by downregulating the ERK1/2 signaling pathway in diabetic mice.
Title: The DR1‑CSE/H(2)S system inhibits renal fibrosis by downregulating the ERK1/2 signaling pathway in diabetic mice.

Submit: New GeneRIF Correction See all GeneRIFs (168)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (13) 1 citation
Targeted (15) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Drd1a (e-PCR), detects polymorphism
- UniSTS:142863

BB284642 (e-PCR)
- UniSTS:208936

Drd1a (e-PCR), detects polymorphism
- UniSTS:506859

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables D3 dopamine receptor binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G-protein alpha-subunit binding	IEA Inferred from Electronic Annotation more info
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables angiotensin receptor binding	ISO Inferred from Sequence Orthology more info
enables arrestin family protein binding	IEA Inferred from Electronic Annotation more info
enables arrestin family protein binding	ISO Inferred from Sequence Orthology more info
enables dopamine binding	IEA Inferred from Electronic Annotation more info
enables dopamine binding	ISO Inferred from Sequence Orthology more info
enables dopamine neurotransmitter receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables dopamine neurotransmitter receptor activity	ISO Inferred from Sequence Orthology more info
enables dopamine neurotransmitter receptor activity, coupled via Gs	IBA Inferred from Biological aspect of Ancestor more info
enables dopamine neurotransmitter receptor activity, coupled via Gs	IDA Inferred from Direct Assay more info	PubMed
enables dopamine neurotransmitter receptor activity, coupled via Gs	IMP Inferred from Mutant Phenotype more info	PubMed
enables dopamine neurotransmitter receptor activity, coupled via Gs	ISO Inferred from Sequence Orthology more info
enables heterocyclic compound binding	ISO Inferred from Sequence Orthology more info
enables heterotrimeric G-protein binding	IEA Inferred from Electronic Annotation more info
enables heterotrimeric G-protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within D-glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled dopamine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled dopamine receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within G protein-coupled dopamine receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within activation of adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in activation of adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating dopamine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult walking behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in associative learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within astrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within behavioral fear response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within behavioral response to cocaine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to catecholamine stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebral cortex GABAergic interneuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within conditioned taste aversion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dentate gyrus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dopamine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eating behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within feeding behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within grooming behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in grooming behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within habituation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hippocampus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within long-term synaptic depression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within maternal behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mating behavior	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modification of postsynaptic structure	EXP Inferred from Experiment more info	PubMed
involved_in modification of postsynaptic structure	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of circadian sleep/wake cycle, sleep	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within operant conditioning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in operant conditioning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peristalsis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within phospholipase C-activating dopamine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phospholipase C-activating dopamine receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within phospholipase C-activating dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within prepulse inhibition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein import into nucleus	EXP Inferred from Experiment more info	PubMed
acts_upstream_of_or_within protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of dopamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of monoatomic ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to amphetamine	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to amphetamine	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cocaine	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensitization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in social behavior	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within startle response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within striatum development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synaptic transmission, dopaminergic	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within temperature homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transmission of nerve impulse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasodilation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of G protein-coupled receptor complex	IEA Inferred from Electronic Annotation more info
part_of G protein-coupled receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in ciliary membrane	IEA Inferred from Electronic Annotation more info
located_in ciliary membrane	ISO Inferred from Sequence Orthology more info
located_in cilium	ISO Inferred from Sequence Orthology more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in dendritic spine head	ISO Inferred from Sequence Orthology more info
located_in dendritic spine neck	ISO Inferred from Sequence Orthology more info
located_in endomembrane system	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in non-motile cilium	IEA Inferred from Electronic Annotation more info
located_in non-motile cilium	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: D(1A) dopamine receptor

Names: D1 receptor; D1A dopamine receptor; G protein-coupled receptor DRD1; dopamine D1 receptor; dopamine receptor D1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291801.1 → NP_001278730.1 D(1A) dopamine receptor

See identical proteins and their annotated locations for NP_001278730.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

BE957273, BY298225, CT030176

Consensus CDS

CCDS26524.1

UniProtKB/Swiss-Prot

B2RPW8, Q61616, Q8C8P8

UniProtKB/TrEMBL

A0A1Y7VK92

Conserved Domains (2) summary

pfam00001
Location:39 → 331

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:40 → 157

7tm_4; Olfactory receptor
NM_010076.3 → NP_034206.1 D(1A) dopamine receptor

See identical proteins and their annotated locations for NP_034206.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AK044723, BE957273, BY287823, CT030176

Consensus CDS

CCDS26524.1

UniProtKB/Swiss-Prot

B2RPW8, Q61616, Q8C8P8

UniProtKB/TrEMBL

A0A1Y7VK92

Related

ENSMUSP00000021932.6, ENSMUST00000021932.6

Conserved Domains (2) summary

pfam00001
Location:39 → 331

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:40 → 157

7tm_4; Olfactory receptor