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    Tmprss15 transmembrane protease, serine 15 [ Mus musculus (house mouse) ]

    Gene ID: 19146, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmprss15provided by MGI
    Official Full Name
    transmembrane protease, serine 15provided by MGI
    Primary source
    MGI:MGI:1197523
    See related
    Ensembl:ENSMUSG00000022857 AllianceGenome:MGI:1197523
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Entk; Prss7
    Summary
    This gene encodes an enzyme that proteolytically activates the pancreatic proenzyme trypsinogen, converting it into trypsin. The encoded protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
    Expression
    Biased expression in small intestine adult (RPKM 1.8) and duodenum adult (RPKM 0.4) See more
    Orthologs
    human all
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    Genomic context

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    See Tmprss15 in Genome Data Viewer
    Location:
    16 C3.1- C3.2; 16 45.41 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (78749896..78887988, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (78953008..79091097, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930570E03 gene Neighboring gene STARR-seq mESC enhancer starr_41312 Neighboring gene STARR-seq mESC enhancer starr_41313 Neighboring gene STARR-seq mESC enhancer starr_41314 Neighboring gene STARR-seq mESC enhancer starr_41315 Neighboring gene chondrolectin Neighboring gene STARR-seq mESC enhancer starr_41316 Neighboring gene STARR-seq mESC enhancer starr_41317 Neighboring gene STARR-seq mESC enhancer starr_41318 Neighboring gene STARR-seq mESC enhancer starr_41319 Neighboring gene aldo-keto reductase family 1, member D1 pseudogene Neighboring gene ribosomal protein S19, pseudogene 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Development of enteropeptidase activity in mouse small intestine: influence of hormones. Arsenault P, et al. Can J Physiol Pharmacol, 1985 May. PMID 3899338
    2. Electrophoretic analysis of pancreatic proteases and zymogen-activating factors in the mouse. Isobe M, et al. J Exp Zool, 1984 Jun. PMID 6379096
    3. Gene expression profiling in a mouse model for African trypanosomiasis. Kierstein S, et al. Genes Immun, 2006 Dec. PMID 17066074, Free PMC Article
    4. Two-dimensional gel analysis of zymogen-activating factors in the small intestine of the mouse. Isobe M, et al. J Exp Zool, 1984 Jul. PMID 6381640
    5. The amino-terminal sequence of the catalytic subunit of bovine enterokinase. Light A, et al. J Protein Chem, 1991 Oct. PMID 1799406

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Enteropeptidase could inhibit osteoclastogenesis in vitro through the cleavage of RANK.
      Title: Inhibition effect of enteropeptidase on RANKL-RANK signalling by cleavage of RANK.
    2. peptide sequencing of amino terminus of light chain of cow enterokinase, identifying the cleavage site
      Title: The amino-terminal sequence of the catalytic subunit of bovine enterokinase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    enteropeptidase
    Names
    enterokinase
    protease, serine, 7 (enterokinase)
    NP_032967.1
    NP_849186.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008941.4 → NP_032967.1  enteropeptidase isoform 1 precursor

      See identical proteins and their annotated locations for NP_032967.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC112257, AC161815
      Consensus CDS
      CCDS28280.1
      UniProtKB/Swiss-Prot
      P97435, Q148Y3
      Related
      ENSMUSP00000023566.5, ENSMUST00000023566.11
      Conserved Domains (11) summary
      cd06263
      Location:392 → 547
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00192
      Location:228 → 261
      LDLa; Low-density lipoprotein receptor domain class A
      smart00020
      Location:829 → 1064
      Tryp_SPc; Trypsin-like serine protease
      smart00200
      Location:53 → 154
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
      smart00202
      Location:723 → 816
      SR; Scavenger receptor Cys-rich
      cd00112
      Location:688 → 722
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:830 → 1066
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00431
      Location:569 → 676
      CUB; CUB domain
      pfam00530
      Location:728 → 819
      SRCR; Scavenger receptor cysteine-rich domain
      pfam00629
      Location:392 → 549
      MAM; MAM domain, meprin/A5/mu
      cl00049
      Location:270 → 376
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    2. NM_178855.5 → NP_849186.2  enteropeptidase isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC112257, AC161815
      Consensus CDS
      CCDS37380.1
      UniProtKB/TrEMBL
      E9Q6Y6
      Related
      ENSMUSP00000052034.6, ENSMUST00000060402.6
      Conserved Domains (11) summary
      cd06263
      Location:377 → 532
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00192
      Location:213 → 246
      LDLa; Low-density lipoprotein receptor domain class A
      smart00020
      Location:814 → 1049
      Tryp_SPc; Trypsin-like serine protease
      smart00200
      Location:53 → 154
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
      smart00202
      Location:708 → 801
      SR; Scavenger receptor Cys-rich
      cd00112
      Location:673 → 707
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:815 → 1051
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00431
      Location:554 → 661
      CUB; CUB domain
      pfam00530
      Location:713 → 804
      SRCR; Scavenger receptor cysteine-rich domain
      pfam00629
      Location:377 → 534
      MAM; MAM domain, meprin/A5/mu
      cl00049
      Location:255 → 361
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      78749896..78887988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97435.1 GenPept UniProtKB/Swiss-Prot:P97435

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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