Hcrtr2 hypocretin (orexin) receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hcrtr2provided by MGI
Official Full Name: hypocretin (orexin) receptor 2provided by MGI
Primary source: MGI:MGI:2680765
See related: Ensembl:ENSMUSG00000032360 AllianceGenome:MGI:2680765
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: OX2R; OXR2; OX2aR; OX2bR; mOXR2; mOX2aR; mOX2bR
Summary: Enables orexin receptor activity. Involved in locomotion. Acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Used to study narcolepsy. Orthologous to human HCRTR2 (hypocretin receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 9 D; 9 42.48 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (76133162..76230905, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (76225880..76323623, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of type 2 orexin receptor in adult mouse testis potentiates testosterone production and germ cell proliferation.
Title: Knockdown of type 2 orexin receptor in adult mouse testis potentiates testosterone production and germ cell proliferation.
Localization and expression of Orexin B (OXB) and its type 2 receptor (OX2R) in mouse testis during postnatal development.
Title: Localization and expression of Orexin B (OXB) and its type 2 receptor (OX2R) in mouse testis during postnatal development.
Orexin 2 receptor (OX2R) protein distribution measured by autoradiography using radiolabeled OX2R-selective antagonist EMPA in rodent brain and peripheral tissues.
Title: Orexin 2 receptor (OX2R) protein distribution measured by autoradiography using radiolabeled OX2R-selective antagonist EMPA in rodent brain and peripheral tissues.
Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity.
Title: Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity.
Orexin 1 and 2 Receptors in the Prelimbic Cortex Modulate Threat Valuation.
Title: Orexin 1 and 2 Receptors in the Prelimbic Cortex Modulate Threat Valuation.
Study demonstrated that activation of the OX1 receptor in the ventrolateral periaqueductal gray of mice can initiate an endocannabinoid-CB1 receptor-mediated analgesia. Activation of the OX2 receptor in the ventrolateral periaqueductal gray was also antinociceptive but this antinociceptive effect is CB1 receptor-independent.
Title: Stress induces analgesia via orexin 1 receptor-initiated endocannabinoid/CB1 signaling in the mouse periaqueductal gray.
Elevation levels of OX1R and OX2R following experimental autoimmune encephalomyelitis induction suggest that alteration in orexinergic system may involve in pathogenesis of multiple sclerosis.
Title: Increase in mRNA Level of Orexin1 and 2 Receptors Following Induction of Experimental Autoimmune Encephalomyelitis in Mice.
In an heart failure model, HCRTR2-deficient mice exhibited poorer cardiac function, worse treadmill exercise capacity, and greater myocardial scarring
Title: Systems Genomics Identifies a Key Role for Hypocretin/Orexin Receptor-2 in Human Heart Failure.
orexin activation of OX2R in the brain centrally enhances bone formation by lowing circulating leptin level.
Title: Orexin regulates bone remodeling via a dominant positive central action and a subordinate negative peripheral action.
Knocking down the Orx2 receptors in the basolateral amygdala increased anxious behavior as measured by reduced social preference and reduced time spent in the center of an open field.
Title: Anxiolytic function of the orexin 2/hypocretin A receptor in the basolateral amygdala.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB392239 (e-PCR)
- UniSTS:208419

D9Mit108 (e-PCR), detects polymorphism
- UniSTS:131657

D9Mit122 (e-PCR), detects polymorphism
- UniSTS:131673

D9Dcr13 (e-PCR), detects polymorphism
- UniSTS:498929

Hcrtr2 (e-PCR), detects polymorphism
- UniSTS:464626

Hcrtr2 (e-PCR), detects polymorphism
- UniSTS:464627

Hcrtr2 (e-PCR), detects polymorphism
- UniSTS:464628

Hcrtr2 (e-PCR), detects polymorphism
- UniSTS:464629

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables orexin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables orexin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables orexin receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian sleep/wake cycle process	IEA Inferred from Electronic Annotation more info
involved_in feeding behavior	IEA Inferred from Electronic Annotation more info
involved_in feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of circadian sleep/wake cycle, wakefulness	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: orexin receptor type 2

Names: hypocretin receptor type 2; orexin receptor type-2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364551.1 → NP_001351480.1 orexin receptor type 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC140311

Consensus CDS

CCDS90628.1

UniProtKB/TrEMBL

B2RU43

Related

ENSMUSP00000139377.2, ENSMUST00000184757.2

Conserved Domains (2) summary

pfam03827
Location:386 → 443

Orexin_rec2; Orexin receptor type 2

cd15208
Location:55 → 375

7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_198962.4 → NP_945200.1 orexin receptor type 2 isoform 1

See identical proteins and their annotated locations for NP_945200.1

Status: VALIDATED

Source sequence(s)

AC140311

Consensus CDS

CCDS23350.1

UniProtKB/Swiss-Prot

P58308, Q5SGC8, Q6VLX3, Q8BG12

UniProtKB/TrEMBL

B2RU43

Related

ENSMUSP00000058230.8, ENSMUST00000063140.15

Conserved Domains (3) summary

pfam00001
Location:71 → 364

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam03827
Location:386 → 443

Orexin_rec2; Orexin receptor type 2

cl21561
Location:65 → 194

7tm_4; Olfactory receptor