Cxcr3 C-X-C motif chemokine receptor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cxcr3provided by RGD
Official Full Name: C-X-C motif chemokine receptor 3provided by RGD
Primary source: RGD:621528
See related: AllianceGenome:RGD:621528
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr9
Summary: Enables C-X-C chemokine receptor activity. Involved in T cell chemotaxis; calcium-mediated signaling; and positive regulation of cytosolic calcium ion concentration. Located in external side of plasma membrane. Used to study dilated cardiomyopathy; high grade glioma; myocarditis; and renovascular hypertension. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CXCR3 (C-X-C motif chemokine receptor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 53.0), Thymus (RPKM 34.7) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq22

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (70884293..70886944, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (66844318..66846969, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (71614346..71616997, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CXCR3 contributes to neuropathic pain via ERK activation in the anterior cingulate cortex.
Title: CXCR3 contributes to neuropathic pain via ERK activation in the anterior cingulate cortex.
Study showed that CXCL10 and CXCR3 expression was induced predominantly in activated neurons after chronic constriction injury. And, it is likely that CXCL10/CXCR3 participates in neuropathic pain via the p-ERK pathway.
Title: Chemokine CXCL10/CXCR3 signaling contributes to neuropathic pain in spinal cord and dorsal root ganglia after chronic constriction injury in rats.
chemokine CXCL10 promotes the development of experimental acute respiratory distress syndrome by binding to its receptor CXCR3
Title: CXCL10/IP-10 Neutralization Can Ameliorate Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats.
the present study leads to an assumption that CXCL10/CXCR3 signaling mediates inhibition of the corticotropin-releasing factor-stimulated adrenocorticotropin-release by interferon-gamma.
Title: CXCL10/CXCR3 signaling mediates inhibitory action by interferon-gamma on CRF-stimulated adrenocorticotropic hormone (ACTH) release.
Dats show that CXCL10 chemokine treatment promoted the activation of p38 MAPK pathway through CXCR3 receptor signaling, thereby up-regulating focal adhesion kinase (FAK) activation and promoted cardiac microvascular endothelial cell migration.
Title: The CXCL10/CXCR3 axis promotes cardiac microvascular endothelial cell migration via the p38/FAK pathway in a proliferation-independent manner.
Our results demonstrated that the activation of spinal chemokine receptor CXCR3 mediated bone cancer pain through Akt and ERK 1/2 kinase
Title: Activation of spinal chemokine receptor CXCR3 mediates bone cancer pain through an Akt-ERK crosstalk pathway in rats.
The chemokine CXCL12, its truncated form SDF-1(5-67), and the receptors CXCR4 and CXCR3 are expressed in human glaucomatous trabecular tissue and a human trabecular cell line.
Title: CXCR3 antagonism of SDF-1(5-67) restores trabecular function and prevents retinal neurodegeneration in a rat model of ocular hypertension.
FK506 suppresses cell proliferation and effecter function, it has less effect on the expression of CCR5 and CXCR3 in lymphocytes.
Title: Effects of a calcineurin inhibitor, FK506, and a CCR5/CXCR3 antagonist, TAK-779, in a rat small intestinal transplantation model.
CXCR3 is up-regulated in ischemia-reperfusion injury of liver in rats.
Title: Expression of the CXC chemokine receptor 3 and its ligands in ischemia-reperfusion injury of liver in rats.
cellular distribution of fractalkine receptor CX3CR1 in the spinal circuit associated with nociceptive transmission supports a potential role in the mechanisms that contribute to the exaggerated pain state in models of neuropathy.
Title: Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

RH133060 (e-PCR)
- UniSTS:216343

PMC127682P1 (e-PCR)
- UniSTS:270557

RH142674 (e-PCR)
- UniSTS:231921

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables C-C chemokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-X-C chemokine binding	ISO Inferred from Sequence Orthology more info
enables C-X-C chemokine binding	ISS Inferred from Sequence or Structural Similarity more info
enables C-X-C chemokine receptor activity	IEA Inferred from Electronic Annotation more info
enables C-X-C chemokine receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables chemokine binding	IEA Inferred from Electronic Annotation more info
enables chemokine binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of execution phase of apoptosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of leukocyte migration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-X-C chemokine receptor type 3

Names: CXC-R3; CXCR-3; G protein-coupled receptor 9; IP-10 receptor; chemokine (C-X-C motif) receptor 3; interferon-inducible protein 10 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053415.1 → NP_445867.1 C-X-C chemokine receptor type 3

See identical proteins and their annotated locations for NP_445867.1

Status: PROVISIONAL

Source sequence(s)

AF223642

UniProtKB/Swiss-Prot

Q9JII9

UniProtKB/TrEMBL

A0A8I5ZZB3, A6IQC9

Conserved Domains (1) summary

pfam00001
Location:73 → 317

7tm_1; 7 transmembrane receptor (rhodopsin family)