Grk1 G protein-coupled receptor kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Grk1provided by RGD
Official Full Name: G protein-coupled receptor kinase 1provided by RGD
Primary source: RGD:619712
See related: EnsemblRapid:ENSRNOG00000018430 AllianceGenome:RGD:619712
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rhok
Summary: Enables rhodopsin kinase activity. Involved in protein autophosphorylation; response to light stimulus; and response to xenobiotic stimulus. Predicted to be located in photoreceptor outer segment. Predicted to be active in cytoplasm. Used to study congestive heart failure. Biomarker of retinal disease. Human ortholog(s) of this gene implicated in Oguchi disease-2 and night blindness. Orthologous to human GRK1 (G protein-coupled receptor kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 4.0), Brain (RPKM 2.6) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.5

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (82821184..82837971, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (76122501..76135792, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (81153489..81165442)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AAMP Regulates Endothelial Cell Migration and Angiogenesis Through RhoA/Rho Kinase Signaling.
Title: AAMP Regulates Endothelial Cell Migration and Angiogenesis Through RhoA/Rho Kinase Signaling.
Cytoskeletal reorganization evoked by Rho-associated kinase- and protein kinase C-catalyzed phosphorylation of cofilin and heat shock protein 27, respectively, contributes to myogenic constriction of rat cerebral arteries.
Title: Cytoskeletal reorganization evoked by Rho-associated kinase- and protein kinase C-catalyzed phosphorylation of cofilin and heat shock protein 27, respectively, contributes to myogenic constriction of rat cerebral arteries.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables rhodopsin kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rhodopsin kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables rhodopsin kinase activity	IEA Inferred from Electronic Annotation more info
enables rhodopsin kinase activity	ISO Inferred from Sequence Orthology more info
enables rhodopsin kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled opsin signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within photoreceptor cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic retina morphogenesis in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of opsin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of opsin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of opsin-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to light stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of retinal rod cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rhodopsin kinase GRK1

Names: G protein-coupled receptpr kinase 1; RK

NP_112358.1

EC 2.7.11.14

XP_038950785.1

EC 2.7.11.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031096.1 → NP_112358.1 rhodopsin kinase GRK1

See identical proteins and their annotated locations for NP_112358.1

Status: PROVISIONAL

Source sequence(s)

U63971

UniProtKB/Swiss-Prot

Q63651

Related

ENSRNOP00000024999.2, ENSRNOT00000024999.6

Conserved Domains (2) summary

cd05608
Location:188 → 475

STKc_GRK1; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1

cl02565
Location:42 → 179

RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

82821184..82837971 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094857.2 → XP_038950785.1 rhodopsin kinase GRK1 isoform X1

Conserved Domains (1) summary

cl21453
Location:1 → 209

PKc_like; Protein Kinases, catalytic domain