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    Btbd2 BTB domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500793, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Btbd2provided by RGD
    Official Full Name
    BTB domain containing 2provided by RGD
    Primary source
    RGD:1566094
    See related
    EnsemblRapid:ENSRNOG00000018788 AllianceGenome:RGD:1566094
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566094
    Summary
    Predicted to be involved in neurogenesis. Predicted to be active in P-body and cytosol. Orthologous to human BTBD2 (BTB domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 139.3), Adrenal (RPKM 109.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Btbd2 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9710392..9726032)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9058609..9075341)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11929859..11943559)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene SUMO-conjugating enzyme UBC9-B-like Neighboring gene MAPK interacting serine/threonine kinase 2 Neighboring gene casein kinase 1, gamma 2 Neighboring gene secretory carrier membrane protein 4 Neighboring gene adenosine deaminase, tRNA-specific 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. Xu L, et al. Exp Cell Res, 2003 Aug 1. PMID 12878161
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein 2
    Names
    BTB (POZ) domain containing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426907.1 → NP_001413836.1  BTB/POZ domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      Related
      ENSRNOP00000025391.8, ENSRNOT00000025391.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      9710392..9726032
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080445.2 → XP_038936373.1  BTB/POZ domain-containing protein 2 isoform X2

      Conserved Domains (3) summary
      cd18523
      Location:193 → 298
      BACK_BTBD2; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2)
      cl38908
      Location:112 → 197
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam08005
      Location:357 → 506
      PHR; PHR domain

    2. XM_039080444.2 → XP_038936372.1  BTB/POZ domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      F1M311
      Conserved Domains (3) summary
      cd18281
      Location:78 → 204
      BTB_POZ_BTBD1_2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2
      cd18523
      Location:200 → 305
      BACK_BTBD2; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2)
      pfam08005
      Location:364 → 513
      PHR; PHR domain

    3. XM_063264094.1 → XP_063120164.1  BTB/POZ domain-containing protein 2 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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