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    Tnni3k TNNI3 interacting kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295531, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tnni3kprovided by RGD
    Official Full Name
    TNNI3 interacting kinaseprovided by RGD
    Primary source
    RGD:727908
    See related
    EnsemblRapid:ENSRNOG00000028225 AllianceGenome:RGD:727908
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cark
    Summary
    Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity and protein kinase activity. Predicted to be involved in protein phosphorylation; regulation of heart contraction; and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to several human genes including TNNI3K (TNNI3 interacting kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 662.5) See more
    Orthologs
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    Genomic context

    See Tnni3k in Genome Data Viewer
    Location:
    2q45
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (246397051..246665000, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (243737346..244005319, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (261069210..261337294, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555516 Neighboring gene transmembrane protein 14C pseudogene Neighboring gene glutamate-rich 3 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta, pseudogene 3 Neighboring gene leucine rich repeat containing 53 Neighboring gene fucose-1-phosphate guanylyltransferase Neighboring gene leucine-rich repeats and IQ motif containing 3 Neighboring gene uncharacterized LOC134486009

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in bundle of His cell to Purkinje myocyte communication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bundle of His cell to Purkinje myocyte communication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bundle of His cell to Purkinje myocyte communication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-serine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cardiac conduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cardiac conduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cardiac muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cardiac muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of heart rate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of heart rate ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase TNNI3K
    Names
    cardiac ankyrin repeat kinase
    NP_861434.1
    XP_038958039.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181769.1NP_861434.1  serine/threonine-protein kinase TNNI3K

      See identical proteins and their annotated locations for NP_861434.1

      Status: PROVISIONAL

      Source sequence(s)
      AY303692
      UniProtKB/Swiss-Prot
      Q7TQP6
      UniProtKB/TrEMBL
      F1LPM9
      Related
      ENSRNOP00000031479.5, ENSRNOT00000030341.8
      Conserved Domains (6) summary
      smart00219
      Location:463719
      TyrKc; Tyrosine kinase, catalytic domain
      cd00204
      Location:99220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14064
      Location:469722
      PKc_TNNI3K; Catalytic domain of the Dual-specificity protein kinase, TNNI3-interacting kinase
      pfam12796
      Location:138232
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:340401
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:134164
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      246397051..246665000 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102111.2XP_038958039.1  serine/threonine-protein kinase TNNI3K isoform X1

      UniProtKB/TrEMBL
      F1LPM9
      Conserved Domains (4) summary
      PHA03095
      Location:120414
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:134164
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:71164
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:469670
      PKc_like; Protein Kinases, catalytic domain