Svip small VCP interacting protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Svipprovided by RGD
Official Full Name: small VCP interacting proteinprovided by RGD
Primary source: RGD:1565432
See related: EnsemblRapid:ENSRNOG00000037137 AllianceGenome:RGD:1565432
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565432
Summary: Predicted to enable ATPase binding activity. Involved in negative regulation of ERAD pathway; negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly; and negative regulation of ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SVIP (small VCP interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 141.3), Testes (RPKM 132.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (110723051..110728741, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (101587128..101592818, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (107368117..107373807, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SVIP is closely associated with the level of autophagy during the development of CCl4-induced hepatic fibrosis. SVIP can induce autophagy and suspend hepatic fibrosis.
Title: SVIP alleviates CCl(4)-induced liver fibrosis via activating autophagy and protecting hepatocytes.
Data sugggest that small valosin-containing protein-interacting protein (SVIP) acts as a regulator of VLDL transport vesicle (VTV) formation by interacting with its cargo and coat proteins.
Title: Silencing of Small Valosin-containing Protein-interacting Protein (SVIP) Reduces Very Low Density Lipoprotein (VLDL) Secretion from Rat Hepatocytes by Disrupting Its Endoplasmic Reticulum (ER)-to-Golgi Trafficking.
SVIP and valosin containing protein were seen to be co-localized in neuronal cell bodies.
Title: Structure and expression of a novel compact myelin protein - small VCP-interacting protein (SVIP).

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ERAD pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ERAD pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of retrograde protein transport, ER to cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of retrograde protein transport, ER to cytosol	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of retrograde protein transport, ER to cytosol	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein lipidation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein lipidation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in smooth endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: small VCP/p97-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.