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    Polr3g RNA polymerase III subunit G [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685465, updated on 9-Dec-2024

    Summary

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    Symbol
    Polr3gprovided by RGD
    Full Name
    RNA polymerase III subunit Gprovided by RGD
    Primary source
    RGD:1593792
    See related
    EnsemblRapid:ENSRNOG00000016260 AllianceGenome:RGD:1593792
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in several processes, including positive regulation of innate immune response; positive regulation of interferon-beta production; and transcription by RNA polymerase III. Predicted to act upstream of or within epithelial cell proliferation. Predicted to be located in cytosol and nuclear body. Predicted to be part of RNA polymerase III complex. Predicted to be active in nucleus. Orthologous to human POLR3G (RNA polymerase III subunit G). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 49.1), Adrenal (RPKM 45.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Polr3g in Genome Data Viewer
    Location:
    2q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (13680893..13721802, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (11945215..11986125, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (9537642..9578551, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17, pseudogene 7 Neighboring gene LysM domain containing 3 Neighboring gene metallo-beta-lactamase domain containing 2 Neighboring gene centrin 3 Neighboring gene uncharacterized LOC134485813

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Two isoforms of human RNA polymerase III with specific functions in cell growth and transformation. Haurie V, et al. Proc Natl Acad Sci U S A, 2010 Mar 2. PMID 20154270, Free PMC Article
    2. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Chiu YH, et al. Cell, 2009 Aug 7. PMID 19631370, Free PMC Article
    3. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Ablasser A, et al. Nat Immunol, 2009 Oct. PMID 19609254, Free PMC Article
    4. Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription. Dumay-Odelot H, et al. Cell Cycle, 2010 Sep 15. PMID 20890107, Free PMC Article
    5. Gene duplication and neofunctionalization: POLR3G and POLR3GL. Renaud M, et al. Genome Res, 2014 Jan. PMID 24107381, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase III subunit RPC7
    Names
    DNA-directed RNA polymerase III subunit RPC7-like
    polymerase (RNA) III (DNA directed) polypeptide G
    polymerase (RNA) III subunit G

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109468.2 → NP_001102938.1  DNA-directed RNA polymerase III subunit RPC7

      See identical proteins and their annotated locations for NP_001102938.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6I4J0, D4A1K1
      Related
      ENSRNOP00000021804.5, ENSRNOT00000021804.8
      Conserved Domains (1) summary
      pfam11705
      Location:1 → 220
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      13680893..13721802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231729.5 → XP_006231791.1  DNA-directed RNA polymerase III subunit RPC7 isoform X1

      See identical proteins and their annotated locations for XP_006231791.1

      UniProtKB/TrEMBL
      A6I4J0, D4A1K1
      Conserved Domains (1) summary
      pfam11705
      Location:1 → 220
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

    2. XM_039103140.2 → XP_038959068.1  DNA-directed RNA polymerase III subunit RPC7 isoform X3

      Conserved Domains (1) summary
      pfam11705
      Location:1 → 153
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

    3. XM_063282557.1 → XP_063138627.1  DNA-directed RNA polymerase III subunit RPC7 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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