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    Sh3rf3 SH3 domain containing ring finger 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294557, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sh3rf3provided by RGD
    Official Full Name
    SH3 domain containing ring finger 3provided by RGD
    Primary source
    RGD:1589772
    See related
    EnsemblRapid:ENSRNOG00000046791 AllianceGenome:RGD:1589772
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sh3md4
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in positive regulation of JNK cascade; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein autoubiquitination. Orthologous to human SH3RF3 (SH3 domain containing ring finger 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 39.5), Brain (RPKM 23.6) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sh3rf3 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (27306937..27642315)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (26765278..27099261)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (28355671..28720020)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ectodysplasin-A receptor Neighboring gene uncharacterized LOC103694417 Neighboring gene uncharacterized LOC134483911 Neighboring gene leucine-rich repeat-containing protein 57-like Neighboring gene uncharacterized LOC134483910 Neighboring gene septin 10 Neighboring gene sosondowah ankyrin repeat domain family member C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Circ-sh3rf3/GATA-4/miR-29a regulatory axis in fibroblast-myofibroblast differentiation and myocardial fibrosis. Ma CX, et al. Cell Mol Life Sci, 2023 Jan 24. PMID 36694058, Free PMC Article
    2. POSH2 is a RING finger E3 ligase with Rac1 binding activity through a partial CRIB domain. Kärkkäinen S, et al. FEBS Lett, 2010 Sep 24. PMID 20696164
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circ-sh3rf3/GATA-4/miR-29a regulatory axis in fibroblast-myofibroblast differentiation and myocardial fibrosis.
      Title: Circ-sh3rf3/GATA-4/miR-29a regulatory axis in fibroblast-myofibroblast differentiation and myocardial fibrosis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase SH3RF3
    Names
    SH3 domain-containing RING finger protein 3
    SH3 multiple domains 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      27306937..27642315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601803.3 → XP_017457292.1  E3 ubiquitin-protein ligase SH3RF3 isoform X1

      UniProtKB/TrEMBL
      M0R6D9
      Related
      ENSRNOP00000064987.3, ENSRNOT00000072485.5

    2. XM_039099198.2 → XP_038955126.1  E3 ubiquitin-protein ligase SH3RF3 isoform X2

      Conserved Domains (3) summary
      PHA03269
      Location:576 → 697
      PHA03269; envelope glycoprotein C; Provisional
      cd16750
      Location:48 → 93
      RING-HC_SH3RF3; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 3 (SH3RF3) and similar proteins
      cl17036
      Location:462 → 518
      SH3; Src Homology 3 domain superfamily

    3. XM_063279663.1 → XP_063135733.1  E3 ubiquitin-protein ligase SH3RF3 isoform X4

    4. XM_039099199.2 → XP_038955127.1  E3 ubiquitin-protein ligase SH3RF3 isoform X5

      UniProtKB/TrEMBL
      A6K3U1
      Conserved Domains (2) summary
      cd16750
      Location:48 → 93
      RING-HC_SH3RF3; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 3 (SH3RF3) and similar proteins
      cl17036
      Location:462 → 518
      SH3; Src Homology 3 domain superfamily

    5. XM_017601804.3 → XP_017457293.1  E3 ubiquitin-protein ligase SH3RF3 isoform X3

    6. XM_039099200.2 → XP_038955128.1  E3 ubiquitin-protein ligase SH3RF3 isoform X6

      Conserved Domains (3) summary
      cd11785
      Location:431 → 485
      SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
      PHA03247
      Location:125 → 358
      PHA03247; large tegument protein UL36; Provisional
      cl17036
      Location:70 → 126
      SH3; Src Homology 3 domain superfamily

    7. XM_039099201.2 → XP_038955129.1  E3 ubiquitin-protein ligase SH3RF3 isoform X7

      Conserved Domains (3) summary
      cd11785
      Location:399 → 453
      SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
      PHA03247
      Location:93 → 326
      PHA03247; large tegument protein UL36; Provisional
      cl17036
      Location:38 → 94
      SH3; Src Homology 3 domain superfamily

    8. XM_039099202.2 → XP_038955130.1  E3 ubiquitin-protein ligase SH3RF3 isoform X7

      Conserved Domains (3) summary
      cd11785
      Location:399 → 453
      SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
      PHA03247
      Location:93 → 326
      PHA03247; large tegument protein UL36; Provisional
      cl17036
      Location:38 → 94
      SH3; Src Homology 3 domain superfamily

    RNA

    1. XR_010061102.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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