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    Cutc cutC copper transporter [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361760, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cutcprovided by RGD
    Official Full Name
    cutC copper transporterprovided by RGD
    Primary source
    RGD:1304966
    See related
    EnsemblRapid:ENSRNOG00000017298 AllianceGenome:RGD:1304966
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable copper ion binding activity. Predicted to be involved in protein tetramerization. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Orthologous to human CUTC (cutC copper transporter). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 96.5), Thymus (RPKM 89.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cutc in Genome Data Viewer
    Location:
    1q54
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (252571489..252586269)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (242622281..242637048)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (263511537..263526308)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ectonucleoside triphosphate diphosphohydrolase 7 Neighboring gene cytochrome c oxidase assembly homolog COX15 Neighboring gene cystatin B, pseudogene 1 Neighboring gene ATP binding cassette subfamily C member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a novel Cut family cDNA that encodes human copper transporter protein CutC. Li J, et al. Biochem Biophys Res Commun, 2005 Nov 11. PMID 16182249
    2. Crystal structure of human copper homeostasis protein CutC reveals a potential copper-binding site. Li Y, et al. J Struct Biol, 2010 Mar. PMID 19878721
    3. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables copper ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein tetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    copper homeostasis protein cutC homolog
    Names
    cutC copper transporter homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108525.2 → NP_001101995.1  copper homeostasis protein cutC homolog isoform 2

      See identical proteins and their annotated locations for NP_001101995.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5ZQP8, A6JHD8, D4A6T5
      Related
      ENSRNOP00000087550.1, ENSRNOT00000113769.2
      Conserved Domains (1) summary
      COG3142
      Location:26 → 262
      CutC; Copper homeostasis protein CutC [Inorganic ion transport and metabolism]

    2. NM_001399691.1 → NP_001386620.1  copper homeostasis protein cutC homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      Related
      ENSRNOP00000023396.7, ENSRNOT00000023396.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      252571489..252586269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084563.2 → XP_038940491.1  copper homeostasis protein cutC homolog isoform X4

      Conserved Domains (1) summary
      cl29988
      Location:26 → 184
      CutC; CutC family

    2. XM_063268682.1 → XP_063124752.1  copper homeostasis protein cutC homolog isoform X3

    3. XM_006231527.3 → XP_006231589.1  copper homeostasis protein cutC homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQP8
      Related
      ENSRNOP00000080809.1, ENSRNOT00000104491.2
      Conserved Domains (1) summary
      COG3142
      Location:26 → 256
      CutC; Copper homeostasis protein CutC [Inorganic ion transport and metabolism]

    4. XM_039084552.2 → XP_038940480.1  copper homeostasis protein cutC homolog isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQP8
      Conserved Domains (1) summary
      COG3142
      Location:2 → 242
      CutC; Copper homeostasis protein CutC [Inorganic ion transport and metabolism]

    RNA

    1. XR_005489132.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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