Mindy2 MINDY lysine 48 deubiquitinase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mindy2provided by RGD
Official Full Name: MINDY lysine 48 deubiquitinase 2provided by RGD
Primary source: RGD:1311456
See related: EnsemblRapid:ENSRNOG00000061337 AllianceGenome:RGD:1311456
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam63b; RGD1311456
Summary: Predicted to enable peptidase activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in chromatin remodeling and proteolysis. Predicted to be located in nucleoplasm. Orthologous to human MINDY2 (MINDY lysine 48 deubiquitinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 185.7), Lung (RPKM 174.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (80149127..80210011, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (71268274..71327698, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (77029346..77089208, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU027017 (e-PCR)
- UniSTS:113711

AI232149 (e-PCR)
- UniSTS:250031

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables K11-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables K48-linked deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables K48-linked deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables K48-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables K6-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables K63-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type carboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type carboxypeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables histone deubiquitinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: MINDY lysine 48 deubiquitinase 2; ubiquitin carboxyl-terminal hydrolase MINDY-2

Names: family with sequence similarity 63, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429419.1 → NP_001416348.1 MINDY lysine 48 deubiquitinase 2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

D3ZWA1
NM_001429420.1 → NP_001416349.1 MINDY lysine 48 deubiquitinase 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I5ZZG8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

80149127..80210011 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_343420.11 → XP_343421.3 ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X1

Related

ENSRNOP00000070456.1, ENSRNOT00000078685.3

Conserved Domains (1) summary

pfam04424
Location:255 → 366

DUF544; Protein of unknown function (DUF544)
XM_017596087.3 → XP_017451576.1 ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X2

Related

ENSRNOP00000083544.1, ENSRNOT00000094906.2
XM_039082503.2 → XP_038938431.1 ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X3

UniProtKB/TrEMBL

A6KES6

Conserved Domains (1) summary

pfam04424
Location:255 → 366

MINDY_DUB; MINDY deubiquitinase