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    Scap SREBF chaperone [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301024, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Scapprovided by RGD
    Official Full Name
    SREBF chaperoneprovided by RGD
    Primary source
    RGD:1309378
    See related
    EnsemblRapid:ENSRNOG00000020853 AllianceGenome:RGD:1309378
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable sterol binding activity. Involved in response to vitamin B3. Part of protein-containing complex. Biomarker of end stage renal disease. Orthologous to human SCAP (SREBF chaperone). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 119.6), Kidney (RPKM 101.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Scap in Genome Data Viewer
    Location:
    8q32
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (119184366..119239086)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (110306026..110360677)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (118551869..118628650)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S23, pseudogene 11 Neighboring gene elongator acetyltransferase complex subunit 6 Neighboring gene protein tyrosine phosphatase, non-receptor type 23 Neighboring gene neutrophilic granule protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles. Yellaturu CR, et al. J Biol Chem, 2009 Mar 20. PMID 19158095, Free PMC Article
    2. Caloric restrictions affect some factors involved in age-related hypercholesterolemia. Martini C, et al. J Cell Biochem, 2007 May 1. PMID 17203467
    3. Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver. Kuriyama H, et al. Cell Metab, 2005 Jan. PMID 16054043
    4. A new feature on the cholesterol-lowering landscape. Rader DJ. Nat Med, 2001 Dec. PMID 11726962
    5. SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. Matsuda M, et al. Genes Dev, 2001 May 15. PMID 11358865, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. insulin selectively stimulates the processing of SREBP-1c in rat hepatocytes by enhancing the association between the SCAP-SREBP-1c complex and COPII proteins and subsequent ER to Golgi transport and proteolytic cleavage.
      Title: Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles.
    2. Caloric restriction affects SREBP involved in age-related hypercholesterolemia.
      Title: Caloric restrictions affect some factors involved in age-related hypercholesterolemia.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sterol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle cargo loading ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in SREBP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in SREBP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cholesterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to insulin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to vitamin B3 IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in ER to Golgi transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of SREBP-SCAP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sterol regulatory element-binding protein cleavage-activating protein
    Names
    SREBP cleavage activating protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100966.2 → NP_001094436.1  sterol regulatory element-binding protein cleavage-activating protein

      See identical proteins and their annotated locations for NP_001094436.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      A2RRU4
      Related
      ENSRNOP00000028295.5, ENSRNOT00000028295.9
      Conserved Domains (5) summary
      smart00320
      Location:771 → 802
      WD40; WD40 repeats
      TIGR00917
      Location:11 → 466
      2A060601; Niemann-Pick C type protein family
      sd00039
      Location:1008 → 1044
      7WD40; WD40 repeat [structural motif]
      pfam12349
      Location:308 → 454
      Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
      cl29593
      Location:1075 → 1232
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      119184366..119239086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265271.1 → XP_063121341.1  sterol regulatory element-binding protein cleavage-activating protein isoform X1

      UniProtKB/Swiss-Prot
      A2RRU4

    2. XM_063265270.1 → XP_063121340.1  sterol regulatory element-binding protein cleavage-activating protein isoform X1

      UniProtKB/Swiss-Prot
      A2RRU4

    3. XM_039081248.2 → XP_038937176.1  sterol regulatory element-binding protein cleavage-activating protein isoform X1

      UniProtKB/Swiss-Prot
      A2RRU4
      Conserved Domains (5) summary
      smart00320
      Location:771 → 802
      WD40; WD40 repeats
      TIGR00917
      Location:11 → 466
      2A060601; Niemann-Pick C type protein family
      sd00039
      Location:1008 → 1044
      7WD40; WD40 repeat [structural motif]
      pfam12349
      Location:308 → 454
      Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
      cl29593
      Location:1075 → 1232
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_017595597.3 → XP_017451086.1  sterol regulatory element-binding protein cleavage-activating protein isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2RRU4.1 GenPept UniProtKB/Swiss-Prot:A2RRU4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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