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    Ncbp3 nuclear cap binding subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360563, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ncbp3provided by RGD
    Official Full Name
    nuclear cap binding subunit 3provided by RGD
    Primary source
    RGD:1308139
    See related
    EnsemblRapid:ENSRNOG00000018550 AllianceGenome:RGD:1308139
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308139
    Summary
    Predicted to enable RNA 7-methylguanosine cap binding activity and mRNA binding activity. Predicted to be involved in defense response to virus; mRNA export from nucleus; and snRNA export from nucleus. Predicted to be located in cytoplasm and nuclear speck. Predicted to be part of nuclear cap binding activity complex. Predicted to be active in nucleus. Orthologous to human NCBP3 (nuclear cap binding subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 161.3), Adrenal (RPKM 146.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ncbp3 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (58164241..58193952)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (57665716..57695432)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (59613398..59643111)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2X 1 Neighboring gene calcium/calmodulin-dependent protein kinase kinase 1 Neighboring gene integrin subunit alpha E Neighboring gene histone H3 associated protein kinase Neighboring gene coiled-coil-helix-coiled-coil-helix domain-containing protein 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3. Gebhardt A, et al. Nat Commun, 2015 Sep 18. PMID 26382858, Free PMC Article
    2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA cap binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 7-methylguanosine mRNA capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in snRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear cap binding complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nuclear cap-binding protein subunit 3
    Names
    uncharacterized protein C17orf85 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108281.1 → NP_001101751.1  nuclear cap-binding protein subunit 3

      See identical proteins and their annotated locations for NP_001101751.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HGH8, D3ZXL5
      Related
      ENSRNOP00000025554.4, ENSRNOT00000025553.6
      Conserved Domains (1) summary
      pfam10309
      Location:123 → 177
      DUF2414; Protein of unknown function (DUF2414)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      58164241..58193952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086326.2 → XP_038942254.1  nuclear cap-binding protein subunit 3 isoform X1

      Conserved Domains (1) summary
      pfam10309
      Location:9 → 63
      NCBP3; Nuclear cap-binding protein subunit 3
    Nucleotide Protein Strain
    Heading Accession and Version

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