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    Plin2 perilipin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298199, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plin2provided by RGD
    Official Full Name
    perilipin 2provided by RGD
    Primary source
    RGD:728889
    See related
    EnsemblRapid:ENSRNOG00000007060 AllianceGenome:RGD:728889
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Adfp; Adrp
    Summary
    Involved in response to organic cyclic compound and response to xenobiotic stimulus. Located in lipid droplet. Orthologous to human PLIN2 (perilipin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 987.2), Adrenal (RPKM 733.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plin2 in Genome Data Viewer
    Location:
    5q32
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (106202634..106258748, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (101156648..101211738, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (104984413..105010863, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene Ras-related GTP binding A Neighboring gene HAUS augmin like complex subunit 6 Neighboring gene small Cajal body-specific RNA 8 Neighboring gene uncharacterized LOC102547623 Neighboring gene uncharacterized LOC134486947 Neighboring gene DENN domain containing 4C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Induction of the adipose differentiation-related protein in liver of etomoxir-treated rats. Steiner S, et al. Biochem Biophys Res Commun, 1996 Jan 26. PMID 8579590
    2. New insight into the mechanisms of ectopic fat deposition improvement after bariatric surgery. Angelini G, et al. Sci Rep, 2019 Nov 21. PMID 31754142, Free PMC Article
    3. Palmitate mediated diacylglycerol accumulation causes endoplasmic reticulum stress, Plin2 degradation, and cell death in H9C2 cardiomyoblasts. Akoumi A, et al. Exp Cell Res, 2017 May 15. PMID 28336294
    4. Evidence for decreased lipofibroblast expression in hypoplastic rat lungs with congenital diaphragmatic hernia. Friedmacher F, et al. Pediatr Surg Int, 2014 Oct. PMID 25023943
    5. Prenatal retinoic acid increases lipofibroblast expression in hypoplastic rat lungs with experimental congenital diaphragmatic hernia. Friedmacher F, et al. J Pediatr Surg, 2014 Jun. PMID 24888826

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRIM21-mediated ubiquitination of PLIN2 regulates neuronal lipid droplet accumulation after acute spinal cord injury.
      Title: TRIM21-mediated ubiquitination of PLIN2 regulates neuronal lipid droplet accumulation after acute spinal cord injury.
    2. Inhibition of perilipin 2 attenuates cerebral ischemia/reperfusion injury by blocking NLRP3 inflammasome activation both in vivo and in vitro.
      Title: Inhibition of perilipin 2 attenuates cerebral ischemia/reperfusion injury by blocking NLRP3 inflammasome activation both in vivo and in vitro.
    3. Perilipin 2 downregulation in beta cells impairs insulin secretion under nutritional stress and damages mitochondria.
      Title: Perilipin 2 downregulation in β cells impairs insulin secretion under nutritional stress and damages mitochondria.
    4. New insight into the mechanisms of ectopic fat deposition improvement after bariatric surgery.
      Title: New insight into the mechanisms of ectopic fat deposition improvement after bariatric surgery.
    5. Endoplasmic reticulum stress induced by either palmitate, tunicamycin, or thapsigargin led to the degradation of Plin2, an important lipid droplet binding protein.
      Title: Palmitate mediated diacylglycerol accumulation causes endoplasmic reticulum stress, Plin2 degradation, and cell death in H9C2 cardiomyoblasts.
    6. It has been demonstrated that ADRP is critically important during fetal lung maturation as it regulates the alveolar lipid homeostasis.
      Title: Evidence for decreased lipofibroblast expression in hypoplastic rat lungs with congenital diaphragmatic hernia.
    7. Increased LIF expression after prenatal treatment with ATRA in nitrofen-induced PH suggests that ATRA may have a therapeutic potential in attenuating CDH-associated PH by stimulating alveolar development.
      Title: Prenatal retinoic acid increases lipofibroblast expression in hypoplastic rat lungs with experimental congenital diaphragmatic hernia.
    8. This study demonstrates, for the first time, the presence of OXPAT and TIP47 transcripts in rat hepatocytes, as well as their up-regulation with lipid accumulation.
      Title: PAT protein mRNA expression in primary rat hepatocytes: Effects of exposure to fatty acids.
    9. Results indicate involvement of OXPAT and ADRP in muscular lipid accumulation and type 2 diabetes.
      Title: Adipocyte differentiation-related protein and OXPAT in rat and human skeletal muscle: involvement in lipid accumulation and type 2 diabetes mellitus.
    10. In steatotic hepatocytes ADRP selectively stains the surface of macrovesicular and microvesicular lipid droplets.
      Title: Adipose differentiation-related protein is a reliable lipid droplet marker in alcoholic fatty liver of rats.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94591

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid droplet disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid storage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid storage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid storage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid storage TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within long-chain fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of sequestering of triglyceride IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    perilipin-2
    Names
    adipose differentiation related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007144.3 → NP_001007145.1  perilipin-2 isoform 1

      See identical proteins and their annotated locations for NP_001007145.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6J875, Q5U2U5
      Conserved Domains (1) summary
      pfam03036
      Location:5 → 404
      Perilipin; Perilipin family

    2. NM_001399043.2 → NP_001385972.1  perilipin-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5ZQJ5, F6QBA3
      Conserved Domains (1) summary
      pfam03036
      Location:5 → 402
      Perilipin; Perilipin family

    3. NM_001400551.1 → NP_001387480.1  perilipin-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6J875, Q5U2U5

    4. NM_001400552.1 → NP_001387481.1  perilipin-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5ZQJ5, F6QBA3
      Related
      ENSRNOP00000079287.1, ENSRNOT00000115133.2

    5. NM_001400553.1 → NP_001387482.1  perilipin-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6J875
      Conserved Domains (1) summary
      pfam03036
      Location:5 → 398
      Perilipin; Perilipin family

    6. NM_001400554.1 → NP_001387483.1  perilipin-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      F6QBA3

    7. NM_001400555.1 → NP_001387484.1  perilipin-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6AJS7
      Related
      ENSRNOP00000093929.1, ENSRNOT00000105644.2

    8. NM_001400556.1 → NP_001387485.1  perilipin-2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      106202634..106258748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109519.2 → XP_038965447.2  perilipin-2 isoform X2

      UniProtKB/TrEMBL
      F6QBA3
      Related
      ENSRNOP00000093118.2, ENSRNOT00000097668.2

    2. XM_063287370.1 → XP_063143440.1  perilipin-2 isoform X7

    3. XM_063287369.1 → XP_063143439.1  perilipin-2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AJS7

    4. XM_063287367.1 → XP_063143437.1  perilipin-2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZQJ5, F6QBA3

    5. XM_039109518.2 → XP_038965446.2  perilipin-2 isoform X1

      UniProtKB/TrEMBL
      A6J875

    6. XM_063287368.1 → XP_063143438.1  perilipin-2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AJS7
      Related
      ENSRNOP00000104576.1, ENSRNOT00000135688.1

    7. XM_039109521.2 → XP_038965449.1  perilipin-2 isoform X3

      UniProtKB/TrEMBL
      A6J875, Q5U2U5
      Conserved Domains (1) summary
      pfam03036
      Location:5 → 404
      Perilipin; Perilipin family
    Nucleotide Protein Strain
    Heading Accession and Version

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