U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pigq phosphatidylinositol glycan anchor biosynthesis, class Q [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287159, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Pigqprovided by RGD
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Qprovided by RGD
    Primary source
    RGD:1359535
    See related
    EnsemblRapid:ENSRNOG00000020140 AllianceGenome:RGD:1359535
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to contribute to phosphatidylinositol N-acetylglucosaminyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 4. Orthologous to human PIGQ (phosphatidylinositol glycan anchor biosynthesis class Q). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 201.0), Kidney (RPKM 188.2) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Pigq in Genome Data Viewer
    Location:
    10q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15447080..15463088, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14942571..14958584, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15289530..15305593, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene methyltransferase like 26 Neighboring gene WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 Neighboring gene Rab40c, member RAS oncogene family Neighboring gene uncharacterized LOC134480763 Neighboring gene proline rich 35 Neighboring gene ribosomal protein L36A, pseudogene 7

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis. Hong Y, et al. J Biol Chem, 1999 Jun 25. PMID 10373468
    2. Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants. Tiede A, et al. Biochem J, 1998 Sep 15. PMID 9729469, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC93737

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to phosphatidylinositol N-acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    phosphatidylinositol N-acetylglucosaminyltransferase subunit Q
    Names
    phosphatidylinositol glycan, class Q
    NP_001007608.1
    XP_006246004.1
    XP_017452559.1
    XP_038941294.1
    XP_063124640.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007607.1 → NP_001007608.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

      See identical proteins and their annotated locations for NP_001007608.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081875
      UniProtKB/TrEMBL
      A0A8I5ZV93, F7F5K8, Q642B8
      Related
      ENSRNOP00000027353.3, ENSRNOT00000027353.6
      Conserved Domains (1) summary
      pfam05024
      Location:303 → 463
      Gpi1; N-acetylglucosaminyl transferase component (Gpi1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      15447080..15463088 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597070.3 → XP_017452559.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZV93
      Conserved Domains (1) summary
      pfam05024
      Location:318 → 463
      Gpi1; N-acetylglucosaminyl transferase component (Gpi1)

    2. XM_039085366.2 → XP_038941294.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZV93, F7F5K8, Q642B8
      Conserved Domains (1) summary
      pfam05024
      Location:303 → 463
      Gpi1; N-acetylglucosaminyl transferase component (Gpi1)

    3. XM_063268570.1 → XP_063124640.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform X2

    4. XM_006245942.5 → XP_006246004.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform X1

      See identical proteins and their annotated locations for XP_006246004.1

      UniProtKB/TrEMBL
      A0A8I5ZV93, F7F5K8, Q642B8
      Conserved Domains (1) summary
      pfam05024
      Location:303 → 463
      Gpi1; N-acetylglucosaminyl transferase component (Gpi1)

    RNA

    1. XR_005489717.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous