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    Slc25a28 solute carrier family 25 member 28 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688811, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc25a28provided by RGD
    Official Full Name
    solute carrier family 25 member 28provided by RGD
    Primary source
    RGD:1584155
    See related
    EnsemblRapid:ENSRNOG00000016751 AllianceGenome:RGD:1584155
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ferrous iron transmembrane transporter activity. Predicted to be involved in iron import into the mitochondrion. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial membrane. Orthologous to human SLC25A28 (solute carrier family 25 member 28). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 150.8), Adrenal (RPKM 147.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc25a28 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (252480106..252491365, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (242530877..242542140, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (263420039..263431312, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485239 Neighboring gene NK2 homeobox 3 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 7 Neighboring gene cytochrome c oxidase assembly homolog COX15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2. Paradkar PN, et al. Mol Cell Biol, 2009 Feb. PMID 19075006, Free PMC Article
    2. Characterization of a putative murine mitochondrial transporter homology of hMRS3/4. Li FY, et al. Mamm Genome, 2002 Jan. PMID 11773964
    3. Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Chen W, et al. Proc Natl Acad Sci U S A, 2009 Sep 22. PMID 19805291, Free PMC Article
    4. Mitoferrin is essential for erythroid iron assimilation. Shaw GC, et al. Nature, 2006 Mar 2. PMID 16511496
    5. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Lane DJ, et al. Biochim Biophys Acta, 2015 May. PMID 25661197

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ferrous iron transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferrous iron transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in iron import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitoferrin-2
    Names
    solute carrier family 25 (mitochondrial iron transporter), member 28

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109515.1 → NP_001102985.1  mitoferrin-2

      See identical proteins and their annotated locations for NP_001102985.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473986
      UniProtKB/TrEMBL
      A6JHD3
      Conserved Domains (1) summary
      pfam00153
      Location:71 → 161
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      252480106..252491365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231567.3 → XP_006231629.1  mitoferrin-2 isoform X1

      UniProtKB/TrEMBL
      G3V865
      Related
      ENSRNOP00000022633.3, ENSRNOT00000022633.7
      Conserved Domains (2) summary
      PTZ00168
      Location:75 → 386
      PTZ00168; mitochondrial carrier protein; Provisional
      pfam00153
      Location:71 → 161
      Mito_carr; Mitochondrial carrier protein

    2. XM_039091206.2 → XP_038947134.1  mitoferrin-2 isoform X2

      Conserved Domains (1) summary
      pfam00153
      Location:1 → 66
      Mito_carr; Mitochondrial carrier protein

    3. XM_039091207.2 → XP_038947135.1  mitoferrin-2 isoform X3

      UniProtKB/TrEMBL
      B2RYH0
      Conserved Domains (1) summary
      pfam00153
      Location:71 → 161
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein Strain
    Heading Accession and Version

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