Sorl1 sortilin related receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Sorl1provided by RGD
Full Name: sortilin related receptor 1provided by RGD
Primary source: RGD:619914
See related: EnsemblRapid:ENSRNOG00000064634 AllianceGenome:RGD:619914
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lr11; SorLA; RGD619914
Summary: Predicted to enable several functions, including amyloid-beta binding activity; aspartic-type endopeptidase inhibitor activity; and low-density lipoprotein particle binding activity. Involved in cell migration. Located in multivesicular body and neuronal cell body. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SORL1 (sortilin related receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 357.3), Brain (RPKM 221.5) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 50

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (51238713..51401458, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (42341704..42504435, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (46228077..46287171, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137847 (e-PCR)
- UniSTS:219934

BM385009 (e-PCR)
- UniSTS:260923

RH133899 (e-PCR)
- UniSTS:217182

BF401246 (e-PCR)
- UniSTS:245444

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables aspartic-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables neuropeptide binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adaptive thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in diet induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in endosome to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor recycling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neurofibrillary tangle assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ER to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of early endosome to recycling endosome transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glial cell-derived neurotrophic factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein exit from endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to early endosome	ISO Inferred from Sequence Orthology more info
involved_in post-Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in protein localization to Golgi apparatus	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	ISO Inferred from Sequence Orthology more info
involved_in protein retention in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein retention in Golgi apparatus	ISO Inferred from Sequence Orthology more info
involved_in protein targeting	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to lysosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to lysosome	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi cisterna	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed
located_in multivesicular body	ISO Inferred from Sequence Orthology more info
located_in multivesicular body membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope lumen	ISO Inferred from Sequence Orthology more info
located_in perinucleolar compartment	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sortilin-related receptor

Names: LDLR relative with 11 ligand-binding repeats; low-density lipoprotein receptor relative with 11 ligand-binding repeats; sortilin-related receptor, LDLR class A repeats-containing; sortilin-related receptor-like; sorting protein-related receptor containing LDLR class A repeats

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053519.1 → NP_445971.1 sortilin-related receptor precursor

See identical proteins and their annotated locations for NP_445971.1

Status: PROVISIONAL

Source sequence(s)

CH473975

UniProtKB/Swiss-Prot

P0DSP1

UniProtKB/TrEMBL

A0A8I5ZUZ4

Related

ENSRNOP00000089955.1, ENSRNOT00000095508.2

Conserved Domains (7) summary

smart00192
Location:1281 → 1308

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:824 → 866

LY; Low-density lipoprotein-receptor YWTD domain

smart00602
Location:124 → 753

VPS10; VPS10 domain

cd00063
Location:1651 → 1742

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00112
Location:1373 → 1403

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:890 → 929

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam00057
Location:1157 → 1192

Ldl_recept_a; Low-density lipoprotein receptor domain class A

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

51238713..51401458 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063265102.1 → XP_063121172.1 sortilin-related receptor isoform X2
XM_039081046.2 → XP_038936974.1 sortilin-related receptor isoform X1

Conserved Domains (6) summary

smart00192
Location:1281 → 1308

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:824 → 866

LY; Low-density lipoprotein-receptor YWTD domain

smart00602
Location:124 → 753

VPS10; VPS10 domain

cd00112
Location:1373 → 1403

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:1157 → 1192

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam00058
Location:890 → 929

Ldl_recept_b; Low-density lipoprotein receptor repeat class B