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    Slc25a27 solute carrier family 25, member 27 [ Mus musculus (house mouse) ]

    Gene ID: 74011, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc25a27provided by MGI
    Official Full Name
    solute carrier family 25, member 27provided by MGI
    Primary source
    MGI:MGI:1921261
    See related
    Ensembl:ENSMUSG00000023912 AllianceGenome:MGI:1921261
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ucp4; UCP 4; 3632410G24Rik; 9430092A03Rik; D530043E16Rik
    Summary
    Predicted to enable chloride transmembrane transporter activity; protein homodimerization activity; and proton transmembrane transporter activity. Acts upstream of or within negative regulation of neuron apoptotic process. Located in mitochondrial inner membrane. Is expressed in central nervous system; neural retina; peripheral nervous system ganglion; and trigeminal nerve. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SLC25A27 (solute carrier family 25 member 27). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E14 (RPKM 9.6), CNS E18 (RPKM 8.3) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc25a27 in Genome Data Viewer
    Location:
    17 B3; 17 19.75 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (43948630..43978105, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (43637739..43667214, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) Neighboring gene RIKEN cDNA 1700071M16 gene Neighboring gene STARR-seq mESC enhancer starr_42598 Neighboring gene tudor domain containing 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:43782177-43782395 Neighboring gene cytochrome P450, family 39, subfamily a, polypeptide 1 Neighboring gene STARR-positive B cell enhancer mm9_chr17:43837943-43838243 Neighboring gene predicted gene, 25783 Neighboring gene STARR-seq mESC enhancer starr_42600 Neighboring gene STARR-seq mESC enhancer starr_42601 Neighboring gene predicted gene, 41581

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Superresolution microscopy reveals spatial separation of UCP4 and F0F1-ATP synthase in neuronal mitochondria. Klotzsch E, et al. Proc Natl Acad Sci U S A, 2015 Jan 6. PMID 25535394, Free PMC Article
    2. Control of mitochondrial pH by uncoupling protein 4 in astrocytes promotes neuronal survival. Perreten Lambert H, et al. J Biol Chem, 2014 Nov 7. PMID 25237189, Free PMC Article
    3. Mitochondrial dysfunction is induced by the overexpression of UCP4 in 3T3-L1 adipocytes. Gao CL, et al. Int J Mol Med, 2010 Jan. PMID 19956904
    4. Ucp4 Knockdown of Cerebellar Purkinje Cells Induces Bradykinesia. Wang YY, et al. Mol Neurobiol, 2024 Feb. PMID 37688710, Free PMC Article
    5. Overexpression of UCP4 in astrocytic mitochondria prevents multilevel dysfunctions in a mouse model of Alzheimer's disease. Rosenberg N, et al. Glia, 2023 Apr. PMID 36537556

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ucp4 Knockdown of Cerebellar Purkinje Cells Induces Bradykinesia.
      Title: Ucp4 Knockdown of Cerebellar Purkinje Cells Induces Bradykinesia.
    2. Overexpression of UCP4 in astrocytic mitochondria prevents multilevel dysfunctions in a mouse model of Alzheimer's disease.
      Title: Overexpression of UCP4 in astrocytic mitochondria prevents multilevel dysfunctions in a mouse model of Alzheimer's disease.
    3. our results suggested DJ-1 might regulate the expression of UCP4 by oxidation of DJ-1 and partially via NF-kappaB pathway in its protective response to oxidative stress
      Title: Parkinson's disease-related DJ-1 modulates the expression of uncoupling protein 4 against oxidative stress.
    4. UCP4 may dissipate the excessive proton gradient, which is usually associated with reactive oxygen species production.
      Title: Superresolution microscopy reveals spatial separation of UCP4 and F0F1-ATP synthase in neuronal mitochondria.
    5. astrocytes expressing more UCP4 produce more lactate, which is used as an energy source by neurons, and have the ability to enhance neuronal survival
      Title: Control of mitochondrial pH by uncoupling protein 4 in astrocytes promotes neuronal survival.
    6. UCP2 is present in cells with highly proliferative potential, which have a glycolytic type of metabolism as a common feature, whereas UCP4 is strongly associated with non-proliferative highly differentiated neuronal cells
      Title: Uncoupling protein 2 and 4 expression pattern during stem cell differentiation provides new insight into their putative function.
    7. Adipocytes overexpressing UcpP4 showed decreased mitochondrial copy number (mtDNA) and lower mRNA expression of key factors in mitochondrial biogenesis, including PGC-1alpha and mtTFA.
      Title: Mitochondrial dysfunction is induced by the overexpression of UCP4 in 3T3-L1 adipocytes.
    8. Results suggest that mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress.
      Title: Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chloride transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chloride transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular triglyceride homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitochondrial calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of D-glucose import ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to cold IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial uncoupling protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357122.1 → NP_001344051.1  mitochondrial uncoupling protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154647, AU254602
      UniProtKB/TrEMBL
      Q9CX10
      Conserved Domains (1) summary
      pfam00153
      Location:122 → 218
      Mito_carr; Mitochondrial carrier protein

    2. NM_001357123.1 → NP_001344052.1  mitochondrial uncoupling protein 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154647, AU254602
      Conserved Domains (1) summary
      pfam00153
      Location:136 → 232
      Mito_carr; Mitochondrial carrier protein

    3. NM_028711.4 → NP_082987.1  mitochondrial uncoupling protein 4 isoform 1

      See identical proteins and their annotated locations for NP_082987.1

      Status: VALIDATED

      Source sequence(s)
      AC154647, AK043831, AU254602
      Consensus CDS
      CCDS28798.1
      UniProtKB/Swiss-Prot
      Q9D6D0
      UniProtKB/TrEMBL
      Q9CX10
      Related
      ENSMUSP00000024705.5, ENSMUST00000024705.6
      Conserved Domains (2) summary
      PTZ00169
      Location:22 → 316
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:122 → 218
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      43948630..43978105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250096.1 → XP_030105956.1  mitochondrial uncoupling protein 4 isoform X10

      Conserved Domains (1) summary
      pfam00153
      Location:20 → 114
      Mito_carr; Mitochondrial carrier protein

    2. XM_030250101.2 → XP_030105961.1  mitochondrial uncoupling protein 4 isoform X12

      Conserved Domains (1) summary
      pfam00153
      Location:7 → 98
      Mito_carr; Mitochondrial carrier protein

    3. XM_030250100.1 → XP_030105960.1  mitochondrial uncoupling protein 4 isoform X12

      Conserved Domains (1) summary
      pfam00153
      Location:7 → 98
      Mito_carr; Mitochondrial carrier protein

    4. XM_030250091.2 → XP_030105951.1  mitochondrial uncoupling protein 4 isoform X6

      Conserved Domains (1) summary
      pfam00153
      Location:77 → 171
      Mito_carr; Mitochondrial carrier protein

    5. XM_017317679.3 → XP_017173168.1  mitochondrial uncoupling protein 4 isoform X2

      Conserved Domains (1) summary
      pfam00153
      Location:138 → 232
      Mito_carr; Mitochondrial carrier protein

    6. XM_030250102.1 → XP_030105962.1  mitochondrial uncoupling protein 4 isoform X12

      Conserved Domains (1) summary
      pfam00153
      Location:7 → 98
      Mito_carr; Mitochondrial carrier protein

    7. XM_006525001.4 → XP_006525064.1  mitochondrial uncoupling protein 4 isoform X3

      UniProtKB/TrEMBL
      Q9CX10
      Conserved Domains (1) summary
      pfam00153
      Location:124 → 218
      Mito_carr; Mitochondrial carrier protein

    8. XM_017317681.3 → XP_017173170.1  mitochondrial uncoupling protein 4 isoform X5

      Conserved Domains (1) summary
      pfam00153
      Location:77 → 171
      Mito_carr; Mitochondrial carrier protein

    9. XM_030250095.2 → XP_030105955.1  mitochondrial uncoupling protein 4 isoform X10

      Conserved Domains (1) summary
      pfam00153
      Location:20 → 114
      Mito_carr; Mitochondrial carrier protein

    10. XM_030250103.2 → XP_030105963.1  mitochondrial uncoupling protein 4 isoform X12

      Conserved Domains (1) summary
      pfam00153
      Location:7 → 98
      Mito_carr; Mitochondrial carrier protein

    11. XM_030250099.2 → XP_030105959.1  mitochondrial uncoupling protein 4 isoform X12

      Conserved Domains (1) summary
      pfam00153
      Location:7 → 98
      Mito_carr; Mitochondrial carrier protein

    12. XM_017317678.3 → XP_017173167.1  mitochondrial uncoupling protein 4 isoform X1

      Conserved Domains (1) summary
      pfam00153
      Location:138 → 232
      Mito_carr; Mitochondrial carrier protein

    13. XM_030250092.2 → XP_030105952.1  mitochondrial uncoupling protein 4 isoform X8

      Conserved Domains (1) summary
      pfam00153
      Location:20 → 114
      Mito_carr; Mitochondrial carrier protein

    14. XM_036160809.1 → XP_036016702.1  mitochondrial uncoupling protein 4 isoform X4

      Conserved Domains (1) summary
      pfam00153
      Location:119 → 215
      Mito_carr; Mitochondrial carrier protein

    15. XM_030250098.2 → XP_030105958.1  mitochondrial uncoupling protein 4 isoform X11

      Conserved Domains (1) summary
      pfam00153
      Location:2 → 98
      Mito_carr; Mitochondrial carrier protein

    16. XM_036160814.1 → XP_036016707.1  mitochondrial uncoupling protein 4 isoform X11

      Conserved Domains (1) summary
      pfam00153
      Location:2 → 98
      Mito_carr; Mitochondrial carrier protein

    17. XM_036160812.1 → XP_036016705.1  mitochondrial uncoupling protein 4 isoform X11

      Conserved Domains (1) summary
      pfam00153
      Location:2 → 98
      Mito_carr; Mitochondrial carrier protein

    18. XM_030250094.2 → XP_030105954.1  mitochondrial uncoupling protein 4 isoform X9

      Conserved Domains (1) summary
      pfam00153
      Location:20 → 114
      Mito_carr; Mitochondrial carrier protein

    19. XM_036160813.1 → XP_036016706.1  mitochondrial uncoupling protein 4 isoform X11

      Conserved Domains (1) summary
      pfam00153
      Location:2 → 98
      Mito_carr; Mitochondrial carrier protein

    20. XM_030250093.2 → XP_030105953.1  mitochondrial uncoupling protein 4 isoform X9

      Conserved Domains (1) summary
      pfam00153
      Location:20 → 114
      Mito_carr; Mitochondrial carrier protein

    21. XM_036160811.1 → XP_036016704.1  mitochondrial uncoupling protein 4 isoform X11

      Conserved Domains (1) summary
      pfam00153
      Location:2 → 98
      Mito_carr; Mitochondrial carrier protein

    22. XM_017317682.3 → XP_017173171.1  mitochondrial uncoupling protein 4 isoform X7

      Conserved Domains (1) summary
      pfam00153
      Location:138 → 232
      Mito_carr; Mitochondrial carrier protein

    RNA

    1. XR_003952195.2 RNA Sequence

    2. XR_004939591.1 RNA Sequence

    3. XR_004939590.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D6D0.1 GenPept UniProtKB/Swiss-Prot:Q9D6D0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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