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    Eef2 eukaryotic translation elongation factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 13629, updated on 18-Jan-2025

    Summary

    Official Symbol
    Eef2provided by MGI
    Official Full Name
    eukaryotic translation elongation factor 2provided by MGI
    Primary source
    MGI:MGI:95288
    See related
    Ensembl:ENSMUSG00000034994 AllianceGenome:MGI:95288
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ef-2
    Summary
    Enables GTPase activity and lncRNA binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation and translational elongation. Located in cytoplasm and ribosome. Is active in synapse. Is expressed in brain and neocortex. Human ortholog(s) of this gene implicated in glaucoma; spinocerebellar ataxia type 26; and stomach cancer. Orthologous to human EEF2 (eukaryotic translation elongation factor 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in ovary adult (RPKM 1248.0), colon adult (RPKM 810.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Eef2 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81012465..81018343)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81176631..81182509)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E463 Neighboring gene STARR-positive B cell enhancer ABC_E8349 Neighboring gene STARR-seq mESC enhancer starr_27318 Neighboring gene zinc finger and BTB domain containing 7a Neighboring gene protein inhibitor of activated STAT 4 Neighboring gene STARR-positive B cell enhancer ABC_E901 Neighboring gene STARR-positive B cell enhancer ABC_E8866 Neighboring gene STARR-positive B cell enhancer ABC_E3901 Neighboring gene STARR-positive B cell enhancer ABC_E5157 Neighboring gene STARR-positive B cell enhancer ABC_E2329 Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene death-associated protein kinase 3 Neighboring gene ataxia, cerebellar, Cayman type, opposite strand Neighboring gene nicotinamide riboside kinase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC98463

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5S rRNA binding  
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity PubMed 
    enables GTPase activity  
    enables RNA binding  
    enables actin filament binding  
    enables lncRNA binding PubMed 
    enables p53 binding  
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein kinase binding  
    enables ribosome binding  
    enables ribosome binding  
    enables ribosome binding  
    enables translation elongation factor activity  
    enables translation elongation factor activity  
    enables translation elongation factor activity  
    Component Evidence Code Pubs
    located_in aggresome  
    located_in aggresome  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol  
    is_active_in glutamatergic synapse  
    NOT located_in nucleus PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    part_of ribonucleoprotein complex  
    part_of ribonucleoprotein complex PubMed 
    located_in ribosome PubMed 
    located_in ribosome  
    is_active_in synapse PubMed 
    is_active_in synapse PubMed 

    General protein information

    Preferred Names
    elongation factor 2
    NP_031933.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007907.3NP_031933.1  elongation factor 2

      See identical proteins and their annotated locations for NP_031933.1

      Status: VALIDATED

      Source sequence(s)
      AC155932
      Consensus CDS
      CCDS35993.1
      UniProtKB/Swiss-Prot
      P58252, Q544E4
      UniProtKB/TrEMBL
      Q3TJZ1, Q3TK17, Q3TX47, Q3UDC8
      Related
      ENSMUSP00000046101.10, ENSMUST00000047864.11
      Conserved Domains (6) summary
      cd01885
      Location:20233
      EF2; Elongation Factor 2 (EF2) in archaea and eukarya
      cd01681
      Location:574746
      aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
      cd04096
      Location:742821
      eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
      PTZ00416
      Location:1858
      PTZ00416; elongation factor 2; Provisional
      cd03700
      Location:394488
      EF2_snRNP_like_II; Domain II of elongation factor 2 and C-terminal domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein
      cd16261
      Location:503574
      EF2_snRNP_III; Domain III of Elongation Factor 2 (EF2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      81012465..81018343
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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