SHC1 SHC adaptor protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SHC1provided by HGNC
Official Full Name: SHC adaptor protein 1provided by HGNC
Primary source: HGNC:HGNC:10840
See related: Ensembl:ENSG00000160691 MIM:600560; AllianceGenome:HGNC:10840
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SHC; SHCA
Summary: This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Expression: Ubiquitous expression in fat (RPKM 25.3), gall bladder (RPKM 24.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q21.3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (154962298..154974376, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (154101659..154113737, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (154934774..154946852, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CCDC6-RET fusion protein regulates Ras/MAPK signaling through the fusion- GRB2-SHC1 signal niche.
Title: CCDC6-RET fusion protein regulates Ras/MAPK signaling through the fusion- GRB2-SHC1 signal niche.
The mitochondria-related gene risk mode revealed p66Shc as a prognostic mitochondria-related gene of glioblastoma.
Title: The mitochondria-related gene risk mode revealed p66Shc as a prognostic mitochondria-related gene of glioblastoma.
MicroRNA 452 regulates SHC1 expression in human colorectal cancer and colitis.
Title: MicroRNA 452 regulates SHC1 expression in human colorectal cancer and colitis.
YES1 Kinase Mediates the Membrane Removal of Rescued F508del-CFTR in Airway Cells by Promoting MAPK Pathway Activation via SHC1.
Title: YES1 Kinase Mediates the Membrane Removal of Rescued F508del-CFTR in Airway Cells by Promoting MAPK Pathway Activation via SHC1.
Mitochondrial Translocation of P66Shc Aggravates Cisplatin-induced AKI by Promoting Ferroptosis.
Title: Mitochondrial Translocation of P66Shc Aggravates Cisplatin-induced AKI by Promoting Ferroptosis.
Dynamics of antioxidant heme oxygenase-1 and pro-oxidant p66Shc in promoting advanced prostate cancer progression.
Title: Dynamics of antioxidant heme oxygenase-1 and pro-oxidant p66Shc in promoting advanced prostate cancer progression.
The p66Shc Protein Mediates Insulin Resistance and Secretory Dysfunction in Pancreatic beta-Cells Under Lipotoxic Conditions.
Title: The p66Shc Protein Mediates Insulin Resistance and Secretory Dysfunction in Pancreatic β-Cells Under Lipotoxic Conditions.
The E3 ubiquitin ligase SOCS-7 reverses immunosuppression via Shc1 signaling in hepatocellular carcinoma.
Title: The E3 ubiquitin ligase SOCS-7 reverses immunosuppression via Shc1 signaling in hepatocellular carcinoma.
Genistein suppresses ox-LDL-elicited oxidative stress and senescence in HUVECs through the SIRT1-p66shc-Foxo3a pathways.
Title: Genistein suppresses ox-LDL-elicited oxidative stress and senescence in HUVECs through the SIRT1-p66shc-Foxo3a pathways.
The increased expression and aberrant methylation of SHC1 in non-small cell lung cancer: Integrative analysis of clinical and bioinformatics databases.
Title: The increased expression and aberrant methylation of SHC1 in non-small cell lung cancer: Integrative analysis of clinical and bioinformatics databases.

Submit: New GeneRIF Correction See all GeneRIFs (173)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	SHC (Src homology 2 domain containing) transforming protein 1 is upregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells	PubMed
	tat	HIV-1 Tat activates the MAPK signaling pathway leading to the phosphorylation of Shc, a protein involved in signal transduction downstream of receptor tyrosine kinase activation	PubMed
	tat	HIV-1 Tat-induced small GTPase Ras activation is mediated by tyrosine phosphorylation of Shc and recruitment of Grb2 in human endothelial cells	PubMed
nucleocapsid	gag	SHC (Src homology 2 domain containing) transforming protein 1 is upregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

Shc1 (e-PCR), detects polymorphism
- UniSTS:532499

D8S2279 (e-PCR)
- UniSTS:473907

D10S16 (e-PCR)
- UniSTS:155756

D15S1477 (e-PCR)
- UniSTS:474482

L17877 (e-PCR)
- UniSTS:61334

D7S2830 (e-PCR)
- UniSTS:4769

SHC1_7874 (e-PCR)
- UniSTS:467885

L17809 (e-PCR)
- UniSTS:39087

RH98253 (e-PCR)
- UniSTS:86706

GDB:631802 (e-PCR)
- UniSTS:158429

RH70874 (e-PCR)
- UniSTS:16098

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ephrin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables epidermal growth factor binding	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables insulin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables insulin-like growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables neurotrophin TRKA receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables phospholipid binding	TAS Traceable Author Statement more info	PubMed
enables phosphotyrosine residue binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase adaptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart development	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell proliferation in bone marrow	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of superoxide metabolic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of Shc-EGFR complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: SHC-transforming protein 1

Names: SH2 domain protein C1; SHC (Src homology 2 domain containing) transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029028.1 RefSeqGene

Range

8737..17186

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001130040.2 → NP_001123512.1 SHC-transforming protein 1 isoform 3

See identical proteins and their annotated locations for NP_001123512.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) encodes the longest isoform (3).

Source sequence(s)

BX647149

Consensus CDS

CCDS44233.1

UniProtKB/TrEMBL

B4DL02

Related

ENSP00000401303.3, ENST00000448116.7

Conserved Domains (2) summary

cd09925
Location:481 → 584

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cd01209
Location:146 → 317

PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
NM_001130041.2 → NP_001123513.1 SHC-transforming protein 1 isoform 4

See identical proteins and their annotated locations for NP_001123513.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) has an alternate 5' sequence and an alternate splice site in the CDS, as compared to variant 3. The resulting isoform (4), also known as p52Shc, has a shorter N-terminus and lacks an internal amino acid, as compared to isoform 3.

Source sequence(s)

AK292143, BC014158, X68148

Consensus CDS

CCDS44234.1

UniProtKB/TrEMBL

B4DL02

Related

ENSP00000357435.1, ENST00000368450.5

Conserved Domains (2) summary

cd09925
Location:370 → 473

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cd01209
Location:36 → 207

PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
NM_001202859.2 → NP_001189788.1 SHC-transforming protein 1 isoform 5 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5) has an alternate 5' sequence and an alternate splice site in the CDS, as compared to variant 3. The resulting isoform (5), also known as p46Shc, has a shorter N-terminus and lacks an internal amino acid, as compared to isoform 3. Variants 4 and 5 have the same nucleotide sequence, but variant 5 represents use of a downstream AUG compared to variant 4.

Source sequence(s)

AK292143, BC014158

UniProtKB/TrEMBL

X6R6D0

Related

ENSP00000357434.4, ENST00000368449.8

Conserved Domains (2) summary

cd09925
Location:325 → 428

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cd01209
Location:1 → 162

PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
NM_003029.5 → NP_003020.2 SHC-transforming protein 1 isoform 2

See identical proteins and their annotated locations for NP_003020.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate 5' sequence, as compared to variant 3. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 3.

Source sequence(s)

AK292143, BC014158

Consensus CDS

CCDS1076.1

UniProtKB/TrEMBL

B4DL02

Related

ENSP00000357438.4, ENST00000368453.8

Conserved Domains (2) summary

cd09925
Location:371 → 474

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cd01209
Location:36 → 207

PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
NM_183001.5 → NP_892113.4 SHC-transforming protein 1 isoform 1

See identical proteins and their annotated locations for NP_892113.4

Status: REVIEWED

Description

Transcript Variant: This variant (1) has an alternate splice site in the CDS, as compared to variant 3. The resulting isoform (1), also known as p66Shc, lacks an internal amino acid, as compared to isoform 3.

Source sequence(s)

BX647149

Consensus CDS

CCDS30881.1

UniProtKB/Swiss-Prot

B5BU19, D3DV78, O15290, P29353, Q5T180, Q5T183, Q5T184, Q5T185, Q5T186, Q8N4K5, Q96CL1

UniProtKB/TrEMBL

B4DL02

Related

ENSP00000357430.5, ENST00000368445.9

Conserved Domains (2) summary

cd09925
Location:480 → 583

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cd01209
Location:146 → 317

PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

154962298..154974376 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017002083.2 → XP_016857572.1 SHC-transforming protein 1 isoform X20

UniProtKB/TrEMBL

B4DL02
XM_047427986.1 → XP_047283942.1 SHC-transforming protein 1 isoform X19
XM_011509897.2 → XP_011508199.1 SHC-transforming protein 1 isoform X18

UniProtKB/TrEMBL

B4DL02

Conserved Domains (2) summary

cd09925
Location:362 → 465

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cd01209
Location:36 → 189

PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
XM_047427994.1 → XP_047283950.1 SHC-transforming protein 1 isoform X22
XM_047427991.1 → XP_047283947.1 SHC-transforming protein 1 isoform X21
XM_047427972.1 → XP_047283928.1 SHC-transforming protein 1 isoform X15
XM_047427970.1 → XP_047283926.1 SHC-transforming protein 1 isoform X14
XM_047427989.1 → XP_047283945.1 SHC-transforming protein 1 isoform X20
XM_047427988.1 → XP_047283944.1 SHC-transforming protein 1 isoform X19
XM_047427995.1 → XP_047283951.1 SHC-transforming protein 1 isoform X22
XM_047427982.1 → XP_047283938.1 SHC-transforming protein 1 isoform X17
XM_047427992.1 → XP_047283948.1 SHC-transforming protein 1 isoform X21
XM_047427974.1 → XP_047283930.1 SHC-transforming protein 1 isoform X16
XM_047427973.1 → XP_047283929.1 SHC-transforming protein 1 isoform X15
XM_047427971.1 → XP_047283927.1 SHC-transforming protein 1 isoform X14
XM_047427959.1 → XP_047283915.1 SHC-transforming protein 1 isoform X7
XM_047427958.1 → XP_047283914.1 SHC-transforming protein 1 isoform X4

UniProtKB/Swiss-Prot

B5BU19, D3DV78, O15290, P29353, Q5T180, Q5T183, Q5T184, Q5T185, Q5T186, Q8N4K5, Q96CL1
XM_047427984.1 → XP_047283940.1 SHC-transforming protein 1 isoform X17
XM_047427993.1 → XP_047283949.1 SHC-transforming protein 1 isoform X21
XM_047427978.1 → XP_047283934.1 SHC-transforming protein 1 isoform X16
XM_047427983.1 → XP_047283939.1 SHC-transforming protein 1 isoform X17
XM_047427975.1 → XP_047283931.1 SHC-transforming protein 1 isoform X16
XM_047427964.1 → XP_047283920.1 SHC-transforming protein 1 isoform X12
XM_017002081.3 → XP_016857570.1 SHC-transforming protein 1 isoform X6

UniProtKB/TrEMBL

B4DL02
XM_011509894.4 → XP_011508196.1 SHC-transforming protein 1 isoform X5

UniProtKB/TrEMBL

B4DL02

Conserved Domains (2) summary

cd09925
Location:472 → 575

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cd01209
Location:146 → 299

PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
XM_047427963.1 → XP_047283919.1 SHC-transforming protein 1 isoform X11
XM_047427962.1 → XP_047283918.1 SHC-transforming protein 1 isoform X10
XM_047427961.1 → XP_047283917.1 SHC-transforming protein 1 isoform X9
XM_011509893.4 → XP_011508195.1 SHC-transforming protein 1 isoform X3

UniProtKB/TrEMBL

B4DL02

Conserved Domains (2) summary

cd09925
Location:489 → 592

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cd01209
Location:146 → 317

PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
XM_047427960.1 → XP_047283916.1 SHC-transforming protein 1 isoform X8
XM_011509892.4 → XP_011508194.1 SHC-transforming protein 1 isoform X2

UniProtKB/TrEMBL

B4DL02

Conserved Domains (2) summary

cd09925
Location:490 → 593

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cd01209
Location:146 → 317

PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
XM_005245449.6 → XP_005245506.1 SHC-transforming protein 1 isoform X1

Conserved Domains (2) summary

cd09925
Location:480 → 583

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cd01209
Location:146 → 317

PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
XM_011509898.3 → XP_011508200.1 SHC-transforming protein 1 isoform X23

UniProtKB/TrEMBL

Q59HB0

Conserved Domains (2) summary

cd09925
Location:314 → 417

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cd01209
Location:1 → 151

PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
XM_005245451.5 → XP_005245508.1 SHC-transforming protein 1 isoform X13

See identical proteins and their annotated locations for XP_005245508.1

UniProtKB/TrEMBL

B4DL02

Conserved Domains (2) summary

cd09925
Location:370 → 473

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cd01209
Location:36 → 207

PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
XM_047427967.1 → XP_047283923.1 SHC-transforming protein 1 isoform X13
XM_047427969.1 → XP_047283925.1 SHC-transforming protein 1 isoform X13
XM_047427968.1 → XP_047283924.1 SHC-transforming protein 1 isoform X13

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

154101659..154113737 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054338246.1 → XP_054194221.1 SHC-transforming protein 1 isoform X20
XM_054338244.1 → XP_054194219.1 SHC-transforming protein 1 isoform X19
XM_054338243.1 → XP_054194218.1 SHC-transforming protein 1 isoform X18
XM_054338251.1 → XP_054194226.1 SHC-transforming protein 1 isoform X22
XM_054338248.1 → XP_054194223.1 SHC-transforming protein 1 isoform X21
XM_054338235.1 → XP_054194210.1 SHC-transforming protein 1 isoform X15
XM_054338233.1 → XP_054194208.1 SHC-transforming protein 1 isoform X14
XM_054338247.1 → XP_054194222.1 SHC-transforming protein 1 isoform X20
XM_054338245.1 → XP_054194220.1 SHC-transforming protein 1 isoform X19
XM_054338252.1 → XP_054194227.1 SHC-transforming protein 1 isoform X22
XM_054338240.1 → XP_054194215.1 SHC-transforming protein 1 isoform X17
XM_054338249.1 → XP_054194224.1 SHC-transforming protein 1 isoform X21
XM_054338237.1 → XP_054194212.1 SHC-transforming protein 1 isoform X16
XM_054338236.1 → XP_054194211.1 SHC-transforming protein 1 isoform X15
XM_054338234.1 → XP_054194209.1 SHC-transforming protein 1 isoform X14
XM_054338223.1 → XP_054194198.1 SHC-transforming protein 1 isoform X7
XM_054338220.1 → XP_054194195.1 SHC-transforming protein 1 isoform X4

UniProtKB/Swiss-Prot

B5BU19, D3DV78, O15290, P29353, Q5T180, Q5T183, Q5T184, Q5T185, Q5T186, Q8N4K5, Q96CL1
XM_054338242.1 → XP_054194217.1 SHC-transforming protein 1 isoform X17
XM_054338250.1 → XP_054194225.1 SHC-transforming protein 1 isoform X21
XM_054338239.1 → XP_054194214.1 SHC-transforming protein 1 isoform X16
XM_054338241.1 → XP_054194216.1 SHC-transforming protein 1 isoform X17
XM_054338238.1 → XP_054194213.1 SHC-transforming protein 1 isoform X16
XM_054338228.1 → XP_054194203.1 SHC-transforming protein 1 isoform X12
XM_054338222.1 → XP_054194197.1 SHC-transforming protein 1 isoform X6
XM_054338221.1 → XP_054194196.1 SHC-transforming protein 1 isoform X5
XM_054338227.1 → XP_054194202.1 SHC-transforming protein 1 isoform X11
XM_054338226.1 → XP_054194201.1 SHC-transforming protein 1 isoform X10
XM_054338225.1 → XP_054194200.1 SHC-transforming protein 1 isoform X9
XM_054338219.1 → XP_054194194.1 SHC-transforming protein 1 isoform X3
XM_054338224.1 → XP_054194199.1 SHC-transforming protein 1 isoform X8
XM_054338218.1 → XP_054194193.1 SHC-transforming protein 1 isoform X2
XM_054338217.1 → XP_054194192.1 SHC-transforming protein 1 isoform X1
XM_054338253.1 → XP_054194228.1 SHC-transforming protein 1 isoform X23
XM_054338229.1 → XP_054194204.1 SHC-transforming protein 1 isoform X13
XM_054338230.1 → XP_054194205.1 SHC-transforming protein 1 isoform X13
XM_054338232.1 → XP_054194207.1 SHC-transforming protein 1 isoform X13
XM_054338231.1 → XP_054194206.1 SHC-transforming protein 1 isoform X13