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    Dgcr8 DGCR8 microprocessor complex subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287954, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dgcr8provided by RGD
    Official Full Name
    DGCR8 microprocessor complex subunitprovided by RGD
    Primary source
    RGD:1306365
    See related
    EnsemblRapid:ENSRNOG00000001886 AllianceGenome:RGD:1306365
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including RNA binding activity; heme binding activity; and protein homodimerization activity. Predicted to be involved in DNA damage response; positive regulation of pre-miRNA processing; and primary miRNA processing. Predicted to act upstream of or within regulation of stem cell proliferation. Predicted to be located in cytosol and nuclear body. Predicted to be part of microprocessor complex. Predicted to be active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human DGCR8 (DGCR8 microprocessor complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 112.6), Spleen (RPKM 84.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dgcr8 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96208959..96241560)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (82704673..82737251)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (86852682..86885233)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene transport and golgi organization 2 homolog Neighboring gene microRNA 185 Neighboring gene AP-3 complex subunit sigma-1-like Neighboring gene microRNA 1306 Neighboring gene sialic acid synthase-like Neighboring gene tRNA methyltransferase 2 homolog A Neighboring gene RAN binding protein 1 Neighboring gene small nucleolar RNA, H/ACA box 77B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CCR1 enhances SUMOylation of DGCR8 by up-regulating ERK phosphorylation to promote spinal nerve ligation-induced neuropathic pain. Shi C, et al. Gene Ther, 2022 Jun. PMID 34413501
    2. The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin. Quick-Cleveland J, et al. Cell Rep, 2014 Jun 26. PMID 24910438, Free PMC Article
    3. Processing of microRNA primary transcripts requires heme in mammalian cells. Weitz SH, et al. Proc Natl Acad Sci U S A, 2014 Feb 4. PMID 24449907, Free PMC Article
    4. Crystal structure of human DGCR8 core. Sohn SY, et al. Nat Struct Mol Biol, 2007 Sep. PMID 17704815
    5. Heme is involved in microRNA processing. Faller M, et al. Nat Struct Mol Biol, 2007 Jan. PMID 17159994

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The 24-h pattern of dgcr8, drosha, and dicer expression in the rat suprachiasmatic nuclei and peripheral tissues and its modulation by angiotensin II.
      Title: The 24-h pattern of dgcr8, drosha, and dicer expression in the rat suprachiasmatic nuclei and peripheral tissues and its modulation by angiotensin II.
    2. CCR1 enhances SUMOylation of DGCR8 by up-regulating ERK phosphorylation to promote spinal nerve ligation-induced neuropathic pain.
      Title: CCR1 enhances SUMOylation of DGCR8 by up-regulating ERK phosphorylation to promote spinal nerve ligation-induced neuropathic pain.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables primary miRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables primary miRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-RNA adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of pre-miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in primary miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of microprocessor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of microprocessor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    microprocessor complex subunit DGCR8
    Names
    DiGeorge syndrome critical region gene 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105865.2 → NP_001099335.1  microprocessor complex subunit DGCR8 isoform 1

      See identical proteins and their annotated locations for NP_001099335.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6JSH6, D4A2G4
      Related
      ENSRNOP00000002581.4, ENSRNOT00000002581.7
      Conserved Domains (3) summary
      smart00456
      Location:302 → 332
      WW; Domain with 2 conserved Trp (W) residues
      cd19867
      Location:505 → 578
      DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
      cd19868
      Location:618 → 686
      DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins

    2. NM_001433749.1 → NP_001420678.1  microprocessor complex subunit DGCR8 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6JSH6, D4A2G4

    3. NM_001433760.1 → NP_001420689.1  microprocessor complex subunit DGCR8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      96208959..96241560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248606.5 → XP_006248668.1  microprocessor complex subunit DGCR8 isoform X1

      Conserved Domains (3) summary
      smart00456
      Location:302 → 332
      WW; Domain with 2 conserved Trp (W) residues
      cd19867
      Location:505 → 578
      DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
      cd19868
      Location:618 → 686
      DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins

    2. XM_039088082.2 → XP_038944010.1  microprocessor complex subunit DGCR8 isoform X2

      Conserved Domains (3) summary
      smart00456
      Location:284 → 314
      WW; Domain with 2 conserved Trp (W) residues
      cd19867
      Location:487 → 560
      DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
      cd19868
      Location:600 → 668
      DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins

    3. XM_039088081.2 → XP_038944009.1  microprocessor complex subunit DGCR8 isoform X1

      UniProtKB/TrEMBL
      A6JSH6, D4A2G4
      Conserved Domains (3) summary
      smart00456
      Location:302 → 332
      WW; Domain with 2 conserved Trp (W) residues
      cd19867
      Location:505 → 578
      DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
      cd19868
      Location:618 → 686
      DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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