Tmod3 tropomodulin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmod3provided by RGD
Official Full Name: tropomodulin 3provided by RGD
Primary source: RGD:1311030
See related: EnsemblRapid:ENSRNOG00000032436 AllianceGenome:RGD:1311030
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable tropomyosin binding activity. Predicted to be involved in actin filament organization; muscle contraction; and myofibril assembly. Predicted to act upstream of or within actin cytoskeleton organization; erythrocyte development; and positive regulation of mitotic cell cycle phase transition. Predicted to be active in striated muscle thin filament. Orthologous to human TMOD3 (tropomodulin 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 442.1), Heart (RPKM 319.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (85131295..85191477, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (76248978..76310855, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (82432165..82492243, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF404332 (e-PCR)
- UniSTS:247048

RH129438 (e-PCR)
- UniSTS:212745

RH129766 (e-PCR)
- UniSTS:213058

RH138160 (e-PCR)
- UniSTS:220247

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables tropomyosin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within erythrocyte development	ISO Inferred from Sequence Orthology more info
acts_upstream_of mitotic cell cycle phase transition	ISO Inferred from Sequence Orthology more info
involved_in pointed-end actin filament capping	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of mitotic cell cycle phase transition	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in striated muscle thin filament	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tropomodulin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011997.1 → NP_001011997.1 tropomodulin-3

See identical proteins and their annotated locations for NP_001011997.1

Status: PROVISIONAL

Source sequence(s)

BC079290

UniProtKB/TrEMBL

A0A8I6GJC0, A6I1D5, F7F0R0, Q6AXW2

Related

ENSRNOP00000111996.1, ENSRNOT00000155874.1

Conserved Domains (2) summary

cd00116
Location:216 → 292

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

pfam03250
Location:5 → 144

Tropomodulin; Tropomodulin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

85131295..85191477 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063265181.1 → XP_063121251.1 tropomodulin-3 isoform X1

UniProtKB/TrEMBL

A0A8I6GJC0, A6I1D5, F7F0R0, Q6AXW2
XM_039081147.2 → XP_038937075.1 tropomodulin-3 isoform X2

Conserved Domains (1) summary

cl39015
Location:77 → 153

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...