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    Plekhg2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 [ Mus musculus (house mouse) ]

    Gene ID: 101497, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plekhg2provided by MGI
    Official Full Name
    pleckstrin homology domain containing, family G (with RhoGef domain) member 2provided by MGI
    Primary source
    MGI:MGI:2141874
    See related
    Ensembl:ENSMUSG00000037552 AllianceGenome:MGI:2141874
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clg; Cslg
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in regulation of actin filament polymerization. Orthologous to human PLEKHG2 (pleckstrin homology and RhoGEF domain containing G2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in thymus adult (RPKM 36.3), spleen adult (RPKM 18.2) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plekhg2 in Genome Data Viewer
    Location:
    7 A3; 7 16.71 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28059028..28072818, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28359603..28372681, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene suppressor of Ty 5, DSIF elongation factor subunit Neighboring gene STARR-seq mESC enhancer starr_18409 Neighboring gene STARR-positive B cell enhancer ABC_E3708 Neighboring gene snoRNA AF357399 Neighboring gene ribosomal protein S16 Neighboring gene STARR-positive B cell enhancer ABC_E445 Neighboring gene STARR-positive B cell enhancer ABC_E1728 Neighboring gene STARR-seq mESC enhancer starr_18413 Neighboring gene nuclear encoded tRNA isoleucine 16 (anticodon TAT) Neighboring gene STARR-positive B cell enhancer ABC_E2821 Neighboring gene STARR-seq mESC enhancer starr_18414 Neighboring gene Paf1, RNA polymerase II complex component Neighboring gene zinc finger protein 36 Neighboring gene STARR-positive B cell enhancer ABC_E289 Neighboring gene mediator complex subunit 29

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Impaired Function of PLEKHG2, a Rho-Guanine Nucleotide-Exchange Factor, Disrupts Corticogenesis in Neurodevelopmental Phenotypes. Nishikawa M, et al. Cells, 2022 Feb 16. PMID 35203342, Free PMC Article
    2. Expression analyses of PLEKHG2, a Rho family-specific guanine nucleotide exchange factor, during mouse brain development. Nishikawa M, et al. Med Mol Morphol, 2021 Jun. PMID 33492483
    3. Activation of clg, a novel dbl family guanine nucleotide exchange factor gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias. Himmel KL, et al. J Biol Chem, 2002 Apr 19. PMID 11839748
    4. Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly. Chai G, et al. Neuron, 2021 Jan 20. PMID 33220177, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression analyses of PLEKHG2, a Rho family-specific guanine nucleotide exchange factor, during mouse brain development.
      Title: Expression analyses of PLEKHG2, a Rho family-specific guanine nucleotide exchange factor, during mouse brain development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family G member 2
    Names
    PH domain-containing family G member 2
    common site lymphoma/leukemia guanine nucleotide exchange factor
    common-site lymphoma/leukemia GEF

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083912.2 → NP_001077381.1  pleckstrin homology domain-containing family G member 2 isoform b

      See identical proteins and their annotated locations for NP_001077381.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a small in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (b), that is missing an internal segment compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC149606
      Consensus CDS
      CCDS52162.1
      UniProtKB/Swiss-Prot
      A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
      UniProtKB/TrEMBL
      G5E8T4
      Related
      ENSMUSP00000112881.2, ENSMUST00000119990.8
      Conserved Domains (2) summary
      cd13243
      Location:259 → 409
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00621
      Location:102 → 277
      RhoGEF; RhoGEF domain

    2. NM_001290542.2 → NP_001277471.1  pleckstrin homology domain-containing family G member 2 isoform b

      See identical proteins and their annotated locations for NP_001277471.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks a small in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (b), that is missing an internal segment compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC149606
      Consensus CDS
      CCDS52162.1
      UniProtKB/Swiss-Prot
      A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
      UniProtKB/TrEMBL
      G5E8T4
      Conserved Domains (2) summary
      cd13243
      Location:259 → 409
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00621
      Location:102 → 277
      RhoGEF; RhoGEF domain

    3. NM_138752.3 → NP_620091.2  pleckstrin homology domain-containing family G member 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC149606
      Consensus CDS
      CCDS21040.2
      UniProtKB/Swiss-Prot
      A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
      UniProtKB/TrEMBL
      E9QKB6
      Related
      ENSMUSP00000092228.5, ENSMUST00000094644.11
      Conserved Domains (2) summary
      cd13243
      Location:260 → 410
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00621
      Location:103 → 278
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      28059028..28072818 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539439.5 → XP_006539502.1  pleckstrin homology domain-containing family G member 2 isoform X2

      See identical proteins and their annotated locations for XP_006539502.1

      UniProtKB/Swiss-Prot
      A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
      UniProtKB/TrEMBL
      D3Z5N8
      Conserved Domains (3) summary
      PTZ00449
      Location:350 → 741
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd13243
      Location:259 → 409
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00621
      Location:102 → 277
      RhoGEF; RhoGEF domain

    2. XM_006539437.5 → XP_006539500.1  pleckstrin homology domain-containing family G member 2 isoform X2

      See identical proteins and their annotated locations for XP_006539500.1

      UniProtKB/Swiss-Prot
      A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
      UniProtKB/TrEMBL
      D3Z5N8
      Related
      ENSMUSP00000113449.2, ENSMUST00000121085.8
      Conserved Domains (3) summary
      PTZ00449
      Location:350 → 741
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd13243
      Location:259 → 409
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00621
      Location:102 → 277
      RhoGEF; RhoGEF domain

    3. XM_011250408.4 → XP_011248710.1  pleckstrin homology domain-containing family G member 2 isoform X1

      See identical proteins and their annotated locations for XP_011248710.1

      UniProtKB/Swiss-Prot
      A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
      Conserved Domains (3) summary
      PTZ00449
      Location:351 → 742
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd13243
      Location:260 → 410
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00621
      Location:103 → 278
      RhoGEF; RhoGEF domain

    4. XM_030241941.2 → XP_030097801.1  pleckstrin homology domain-containing family G member 2 isoform X5

      UniProtKB/Swiss-Prot
      A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
      Conserved Domains (3) summary
      PTZ00449
      Location:308 → 699
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd13243
      Location:217 → 367
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00621
      Location:60 → 235
      RhoGEF; RhoGEF domain

    5. XM_006539441.4 → XP_006539504.1  pleckstrin homology domain-containing family G member 2 isoform X5

      See identical proteins and their annotated locations for XP_006539504.1

      UniProtKB/Swiss-Prot
      A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
      Conserved Domains (3) summary
      PTZ00449
      Location:308 → 699
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd13243
      Location:217 → 367
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00621
      Location:60 → 235
      RhoGEF; RhoGEF domain

    6. XM_036152530.1 → XP_036008423.1  pleckstrin homology domain-containing family G member 2 isoform X5

      UniProtKB/Swiss-Prot
      A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
      Conserved Domains (3) summary
      PTZ00449
      Location:308 → 699
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd13243
      Location:217 → 367
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00621
      Location:60 → 235
      RhoGEF; RhoGEF domain

    7. XM_036152531.1 → XP_036008424.1  pleckstrin homology domain-containing family G member 2 isoform X5

      UniProtKB/Swiss-Prot
      A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
      Conserved Domains (3) summary
      PTZ00449
      Location:308 → 699
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd13243
      Location:217 → 367
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00621
      Location:60 → 235
      RhoGEF; RhoGEF domain

    8. XM_036152534.1 → XP_036008427.1  pleckstrin homology domain-containing family G member 2 isoform X6

      UniProtKB/Swiss-Prot
      A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
      Conserved Domains (2) summary
      cd13243
      Location:217 → 367
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00621
      Location:60 → 235
      RhoGEF; RhoGEF domain

    9. XM_036152532.1 → XP_036008425.1  pleckstrin homology domain-containing family G member 2 isoform X6

      UniProtKB/Swiss-Prot
      A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
      Related
      ENSMUST00000128015.8
      Conserved Domains (2) summary
      cd13243
      Location:217 → 367
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00621
      Location:60 → 235
      RhoGEF; RhoGEF domain

    10. XM_036152533.1 → XP_036008426.1  pleckstrin homology domain-containing family G member 2 isoform X6

      UniProtKB/Swiss-Prot
      A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
      Conserved Domains (2) summary
      cd13243
      Location:217 → 367
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00621
      Location:60 → 235
      RhoGEF; RhoGEF domain

    11. XM_006539436.5 → XP_006539499.1  pleckstrin homology domain-containing family G member 2 isoform X1

      See identical proteins and their annotated locations for XP_006539499.1

      UniProtKB/Swiss-Prot
      A0PJD9, Q3UNL4, Q6KAU7, Q6PGK2, Q7TS89, Q8R4H6
      Conserved Domains (3) summary
      PTZ00449
      Location:351 → 742
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd13243
      Location:260 → 410
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00621
      Location:103 → 278
      RhoGEF; RhoGEF domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6KAU7.2 GenPept UniProtKB/Swiss-Prot:Q6KAU7

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